ID   DAA10_XENLA             Reviewed;         358 AA.
AC   Q5M7F6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Dynein axonemal assembly factor 10 {ECO:0000305};
DE   AltName: Full=WD repeat-containing protein 92;
GN   Name=dnaaf10; Synonyms=wdr92;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key assembly factor specifically required for the stability
CC       of axonemal dynein heavy chains in cytoplasm.
CC       {ECO:0000250|UniProtKB:A8J3F6}.
CC   -!- SUBUNIT: Interacts with PIH1D1; the interaction associates DNAAF10 with
CC       the R2TP complex (By similarity). Interacts with several dynein
CC       axonemal assembly factors (By similarity).
CC       {ECO:0000250|UniProtKB:A8J3F6, ECO:0000250|UniProtKB:Q96MX6}.
CC   -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:A8J3F6}.
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DR   EMBL; BC088674; AAH88674.1; -; mRNA.
DR   RefSeq; NP_001088869.1; NM_001095400.1.
DR   AlphaFoldDB; Q5M7F6; -.
DR   SMR; Q5M7F6; -.
DR   BioGRID; 106292; 2.
DR   IntAct; Q5M7F6; 1.
DR   MaxQB; Q5M7F6; -.
DR   DNASU; 496212; -.
DR   GeneID; 496212; -.
DR   KEGG; xla:496212; -.
DR   CTD; 496212; -.
DR   Xenbase; XB-GENE-980481; dnaaf10.L.
DR   OMA; RWEATMK; -.
DR   OrthoDB; 1030954at2759; -.
DR   Proteomes; UP000186698; Chromosome 5L.
DR   Bgee; 496212; Expressed in testis and 19 other tissues.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..358
FT                   /note="Dynein axonemal assembly factor 10"
FT                   /id="PRO_0000301674"
FT   REPEAT          64..106
FT                   /note="WD 1"
FT   REPEAT          116..155
FT                   /note="WD 2"
FT   REPEAT          163..206
FT                   /note="WD 3"
FT   REPEAT          208..250
FT                   /note="WD 4"
FT   REPEAT          258..298
FT                   /note="WD 5"
FT   REPEAT          320..358
FT                   /note="WD 6"
SQ   SEQUENCE   358 AA;  39364 MW;  85697AD181F8F200 CRC64;
     MSSPLEKPQI IAHVQKSVNY TLFDCKWIPC SAKFVCVGNL ARGSGVLQVY EIQQGEAKLL
     QETEKPKPIK CGTFGASSMQ QRYLATGDFG GNLNIWNLEA PDTPVYSAKG HNEIINCIDG
     VGGVGIGDGA PEIVTGSRDG TVKVWDPRQK DTPVANMEPA AGEAKRDCWT VAFGNAYNEQ
     ERAVCAGYDN GDIKLFDLRN MSVRWETNIK NGVCSLEFDR KDIVMNKLVA TSLEGKFHVF
     DMRTQHPTKG FASVSEKAHK STVWQVRHLP QNRDVFMTSG GAGNLHLWKY EYPAQRSRKD
     SDGVDTGVAG SASLLQNVTL STQPISSLDW SPDKKGLCVC TSFDQTVRVL IVTKLNRL