ID   DAA10_XENTR             Reviewed;         358 AA.
AC   A4QNE6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Dynein axonemal assembly factor 10 {ECO:0000305};
DE   AltName: Full=WD repeat-containing protein 92;
GN   Name=dnaaf10; Synonyms=wdr92;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Key assembly factor specifically required for the stability
CC       of axonemal dynein heavy chains in cytoplasm.
CC       {ECO:0000250|UniProtKB:A8J3F6}.
CC   -!- SUBUNIT: Interacts with PIH1D1; the interaction associates DNAAF10 with
CC       the R2TP complex (By similarity). Interacts with several dynein
CC       axonemal assembly factors (By similarity).
CC       {ECO:0000250|UniProtKB:A8J3F6, ECO:0000250|UniProtKB:Q96MX6}.
CC   -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:A8J3F6}.
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DR   EMBL; BC135537; AAI35538.1; -; mRNA.
DR   RefSeq; NP_001096516.1; NM_001103046.1.
DR   AlphaFoldDB; A4QNE6; -.
DR   SMR; A4QNE6; -.
DR   PaxDb; A4QNE6; -.
DR   DNASU; 100125149; -.
DR   GeneID; 100125149; -.
DR   KEGG; xtr:100125149; -.
DR   CTD; 116143; -.
DR   Xenbase; XB-GENE-980477; dnaaf10.
DR   eggNOG; ENOG502QRKB; Eukaryota.
DR   InParanoid; A4QNE6; -.
DR   OrthoDB; 1030954at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
DR   GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF00400; WD40; 1.
DR   SMART; SM00320; WD40; 5.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   2: Evidence at transcript level;
KW   Apoptosis; Cytoplasm; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..358
FT                   /note="Dynein axonemal assembly factor 10"
FT                   /id="PRO_0000301675"
FT   REPEAT          64..106
FT                   /note="WD 1"
FT   REPEAT          116..155
FT                   /note="WD 2"
FT   REPEAT          163..206
FT                   /note="WD 3"
FT   REPEAT          208..250
FT                   /note="WD 4"
FT   REPEAT          258..298
FT                   /note="WD 5"
FT   REPEAT          320..358
FT                   /note="WD 6"
SQ   SEQUENCE   358 AA;  39560 MW;  568299D7621CE075 CRC64;
     MSSPLEKPQI IAHVQKPVTY TLFDCKWIPC SAKFVCVGNL ARGSGVLQVY EIQQGEAKLL
     QEAEKPKPIK CGTFGASSLQ QRYLATGDFG GNLNIWNLEA PDTPVYSAKG HNEIINCIDG
     VGGVGIGEGA PEIVTGSRDG TVKVWDPRQK DTPVANMEPA AGETKRDCWT VAFGHAYNEQ
     ERLVCAGYDN GDIKLFDLRN MSVRWETNIK NGVCSLEFDR KDIVMNKLVA TSLEGKFHVF
     DMRTQHPSKG FASMSEKAHK STIWQVRHLP QNRDVFMTSG GAGNLHLWKY EYPAQRSRKD
     SDDVDMGVAG SVSLLQNVTL STQPISSMDW SPDKKGLCVC TSFDQTVRVL IVTKLNKL