DAA11_BOVIN
ID DAA11_BOVIN Reviewed; 472 AA.
AC Q1RMR5;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Dynein axonemal assembly factor 11 {ECO:0000305};
DE Short=DNAAF11 {ECO:0000305};
DE AltName: Full=Leucine-rich repeat-containing protein 6;
DE AltName: Full=Leucine-rich testis-specific protein;
DE AltName: Full=Protein tilB homolog;
DE AltName: Full=Testis-specific leucine-rich repeat protein;
GN Name=DNAAF11; Synonyms=LRRC6, LRTP, TSLRP;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Hereford;
RX PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT "A whole-genome assembly of the domestic cow, Bos taurus.";
RL Genome Biol. 10:R42.01-R42.10(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Uterus;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in dynein arm assembly, is important for expression
CC and transporting outer dynein arm (ODA) proteins from the cytoplasm to
CC the cilia. Acts as a crucial component in the formation and motility of
CC spermatozoal flagella. {ECO:0000250|UniProtKB:Q86X45}.
CC -!- SUBUNIT: Interacts (via CS domain) with ZMYND10 (via C-terminus).
CC {ECO:0000250|UniProtKB:Q86X45}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86X45}. Cell
CC projection, cilium {ECO:0000250|UniProtKB:Q86X45}. Dynein axonemal
CC particle {ECO:0000250|UniProtKB:A0A1L8G016}. Cell projection, cilium,
CC flagellum {ECO:0000250|UniProtKB:Q86X45}.
CC -!- SIMILARITY: Belongs to the tilB family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DAAA02037595; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC114759; AAI14760.1; -; mRNA.
DR RefSeq; NP_001069372.1; NM_001075904.1.
DR AlphaFoldDB; Q1RMR5; -.
DR SMR; Q1RMR5; -.
DR STRING; 9913.ENSBTAP00000045522; -.
DR PaxDb; Q1RMR5; -.
DR PRIDE; Q1RMR5; -.
DR GeneID; 527979; -.
DR KEGG; bta:527979; -.
DR CTD; 23639; -.
DR eggNOG; KOG0531; Eukaryota.
DR HOGENOM; CLU_034806_0_1_1; -.
DR InParanoid; Q1RMR5; -.
DR OrthoDB; 800324at2759; -.
DR TreeFam; TF324815; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; ISS:UniProtKB.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; ISS:UniProtKB.
DR GO; GO:0051649; P:establishment of localization in cell; ISS:UniProtKB.
DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0036158; P:outer dynein arm assembly; ISS:UniProtKB.
DR GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR GO; GO:0120229; P:protein localization to motile cilium; ISS:UniProtKB.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR SMART; SM00446; LRRcap; 1.
DR PROSITE; PS51450; LRR; 5.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Flagellum;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..472
FT /note="Dynein axonemal assembly factor 11"
FT /id="PRO_0000414858"
FT REPEAT 20..44
FT /note="LRR 1"
FT REPEAT 46..65
FT /note="LRR 2"
FT REPEAT 66..89
FT /note="LRR 3"
FT REPEAT 90..110
FT /note="LRR 4"
FT DOMAIN 128..146
FT /note="LRRCT"
FT DOMAIN 305..406
FT /note="CS"
FT REGION 187..210
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 398..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 177..202
FT /evidence="ECO:0000255"
FT COMPBIAS 187..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..291
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 413..427
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 434..459
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 472 AA; 54542 MW; 69EB6877E5E77CBE CRC64;
MGRITEDLIR RNAEHNDCVI FSLEELSLHQ QEIERLEHID KWCRDLKILY LQNNLIGKIE
NVSKLKKLEY LNLALNNIEK IENLEGCEGL TKLDLTVNFI GELSSVKTLQ GNIHLKELFL
MGNPCADFDG YRQFVVATLQ QLKWLDGKEI ERSERIQALQ NLPVVEQRIR EQEKAYCLKR
AKDKEEAQRK LEEEESKGEM GRSHTGSGGH WHADLSATLP SFEESKDYIQ APEIEEGQCK
GKEFDDREDD LEFWNKPSLY TPESRLETLR HMEKQRRDQE RLSEKKKKVK PPRMLVTEDG
RALNVNEPKL DFTLKDDEKR NQIVLDLAVY RYMDTSLIDV DVQPTYVRVM VKGKPFQLIL
PAEVKPDSSF AKRSQTTGHL VVCMPKVGEV IIGCQRTSKP VKSTPDSSKE QTSKSQQMER
LEVDPSKRSI PDVANIVQEK KHMPRRVCAE PKIIPSEEDP DFEDNPEVPP LI
