ACT17_DICDI
ID ACT17_DICDI Reviewed; 374 AA.
AC Q554S6; Q6LEI3; Q8T299;
DT 04-DEC-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-MAY-2006, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Actin-17;
DE AltName: Full=Actin-2-sub 2;
GN Name=act17; Synonyms=act2-2; ORFNames=DDB_G0274131;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-41.
RX PubMed=293714; DOI=10.1073/pnas.76.12.6206;
RA Firtel R.A., Timm R., Kimmel A.R., McKeown M.;
RT "Unusual nucleotide sequences at the 5' end of actin genes in Dictyostelium
RT discoideum.";
RL Proc. Natl. Acad. Sci. U.S.A. 76:6206-6210(1979).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 320-374.
RC STRAIN=AX3;
RX PubMed=6276562; DOI=10.1016/0022-2836(81)90425-3;
RA McKeown M., Firtel R.A.;
RT "Evidence for sub-families of actin genes in Dictyostelium as determined by
RT comparisons of 3' end sequences.";
RL J. Mol. Biol. 151:593-606(1981).
CC -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC various types of cell motility and are ubiquitously expressed in all
CC eukaryotic cells. Multiple isoforms are involved in various cellular
CC functions such as cytoskeleton structure, cell mobility, chromosome
CC movement and muscle contraction (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR EMBL; AAFI02000012; EAL69958.1; -; Genomic_DNA.
DR EMBL; J01268; AAR23116.1; -; Genomic_DNA.
DR EMBL; K02955; AAR23117.1; -; Genomic_DNA.
DR RefSeq; XP_644247.1; XM_639155.1.
DR AlphaFoldDB; Q554S6; -.
DR SMR; Q554S6; -.
DR STRING; 44689.DDB0185125; -.
DR PaxDb; Q554S6; -.
DR PRIDE; Q554S6; -.
DR EnsemblProtists; EAL69958; EAL69958; DDB_G0274131.
DR GeneID; 8619675; -.
DR KEGG; ddi:DDB_G0274131; -.
DR dictyBase; DDB_G0274131; act17.
DR eggNOG; KOG0676; Eukaryota.
DR HOGENOM; CLU_027965_0_2_1; -.
DR InParanoid; Q554S6; -.
DR PhylomeDB; Q554S6; -.
DR Reactome; R-DDI-114608; Platelet degranulation.
DR Reactome; R-DDI-196025; Formation of annular gap junctions.
DR Reactome; R-DDI-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR Reactome; R-DDI-5626467; RHO GTPases activate IQGAPs.
DR Reactome; R-DDI-5663213; RHO GTPases Activate WASPs and WAVEs.
DR Reactome; R-DDI-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-DDI-9013418; RHOBTB2 GTPase cycle.
DR PRO; PR:Q554S6; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0015629; C:actin cytoskeleton; ISS:dictyBase.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0017022; F:myosin binding; ISS:dictyBase.
DR GO; GO:0005200; F:structural constituent of cytoskeleton; ISS:dictyBase.
DR GO; GO:0006909; P:phagocytosis; ISS:dictyBase.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR PRINTS; PR00190; ACTIN.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00406; ACTINS_1; 1.
DR PROSITE; PS00432; ACTINS_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW Reference proteome.
FT CHAIN 1..374
FT /note="Actin-17"
FT /id="PRO_0000312671"
FT CONFLICT 13
FT /note="N -> K (in Ref. 3; AAR23116)"
FT /evidence="ECO:0000305"
FT CONFLICT 15
FT /note="S -> F (in Ref. 3; AAR23116)"
FT /evidence="ECO:0000305"
FT CONFLICT 35
FT /note="I -> N (in Ref. 3; AAR23116)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 374 AA; 41571 MW; F704388B42FC3C42 CRC64;
MECGDVQALV IDNGSSISKA GFAGDDAPRA VFPSIVGRQR YRDVMVGMGQ KDSYVGDEAQ
SKRGILNLKY PIERGIITNW DDMEKIWHHT FYNELRVAPE EHPIHLTLSP SSSKANREKM
TQIMFETFSN PAMYISIQSA LSLYASGLTT GIVIDSGDGV SHTVPILEGH SINHAISRLD
LAGNDLTDYL GKLLSGRGYP FISIDETEIV RDIKEKLSYI TLDFQNEIKI VSSALEKSYE
LPDGKVISIG NELFRCPEAL FQPSFLGMES AGIHETTYNS IMKCDVDIRK DLYDNVVLSG
GTTMFPGIAD RMNKELTALA PSTMKIKIIA PPERKYSVWI GGSMLSSLST FQQMWISKEE
YDESGPSIVH RKCF
