ID   DAA11_TRYBB             Reviewed;         383 AA.
AC   Q9NJE9;
DT   25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Dynein axonemal assembly factor 11 {ECO:0000305};
DE            Short=DNAAF11 {ECO:0000305};
DE   AltName: Full=Leucine-rich repeat-containing protein 6;
DE   AltName: Full=Leucine-rich testis-specific protein;
DE            Short=TbLRTP;
DE   AltName: Full=Phosphatase;
DE   AltName: Full=Protein tilB homolog;
GN   Name=dnaaf11; Synonyms=lrrc6, LRTP, Pho1;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=427;
RX   PubMed=15831481; DOI=10.1128/mcb.25.9.3774-3783.2005;
RA   Morgan G.W., Denny P.W., Vaughan S., Goulding D., Jeffries T.R.,
RA   Smith D.F., Gull K., Field M.C.;
RT   "An evolutionarily conserved coiled-coil protein implicated in polycystic
RT   kidney disease is involved in basal body duplication and flagellar
RT   biogenesis in Trypanosoma brucei.";
RL   Mol. Cell. Biol. 25:3774-3783(2005).
CC   -!- FUNCTION: Involved in the regulation of the cell cycle; is required for
CC       the basal body replication and new flagellum biogenesis.
CC       {ECO:0000269|PubMed:15831481}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC       {ECO:0000269|PubMed:15831481}. Cytoplasm, cytoskeleton, flagellum basal
CC       body {ECO:0000269|PubMed:15831481}.
CC   -!- SIMILARITY: Belongs to the tilB family. {ECO:0000305}.
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DR   EMBL; AF152174; AAF73195.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9NJE9; -.
DR   SMR; Q9NJE9; -.
DR   PRIDE; Q9NJE9; -.
DR   GO; GO:0036064; C:ciliary basal body; IDA:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0005856; C:cytoskeleton; IDA:UniProtKB.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0005576; C:extracellular region; IEA:GOC.
DR   GO; GO:0031514; C:motile cilium; IDA:UniProtKB.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0007099; P:centriole replication; IMP:UniProtKB.
DR   GO; GO:0044782; P:cilium organization; IMP:UniProtKB.
DR   GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB.
DR   GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; ISS:UniProtKB.
DR   GO; GO:0051649; P:establishment of localization in cell; ISS:UniProtKB.
DR   GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR   GO; GO:0036158; P:outer dynein arm assembly; ISS:UniProtKB.
DR   GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR   GO; GO:0120229; P:protein localization to motile cilium; ISS:UniProtKB.
DR   GO; GO:0051726; P:regulation of cell cycle; IMP:UniProtKB.
DR   Gene3D; 3.80.10.10; -; 1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR   SMART; SM00446; LRRcap; 1.
DR   PROSITE; PS51450; LRR; 4.
PE   3: Inferred from homology;
KW   Cell cycle; Cell projection; Cilium; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Developmental protein; Flagellum; Leucine-rich repeat; Repeat.
FT   CHAIN           1..383
FT                   /note="Dynein axonemal assembly factor 11"
FT                   /id="PRO_0000415146"
FT   REPEAT          20..45
FT                   /note="LRR 1"
FT   REPEAT          46..66
FT                   /note="LRR 2"
FT   REPEAT          67..89
FT                   /note="LRR 3"
FT   REPEAT          90..110
FT                   /note="LRR 4"
FT   DOMAIN          128..146
FT                   /note="LRRCT"
FT   REGION          201..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          211..239
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   383 AA;  44316 MW;  E413E4FB3884609F CRC64;
     MGRITTDLLR RRAEHNEGCL SNLKEVALHQ QDIERIELIG DACRELEILY LCNNYISRIE
     GLQHLKYLKY LNLAVNNITY IEGLEGCEAL ERLDLTLNFV ADVTCVERLR ANAFLDQLHL
     TGNPCTKVAG YRAYVVHALP QLRELDGEEV IKTERLEARQ SKDDISVAVN EEALRLQKRS
     VSSQRWLHEA LTAFPPRYNE KGERLYGHTP EERLQMLREK EEEERRKREE QRERERSSQF
     GAIREELERK PQRLTAEEEI AKHGRLLLRN EPKLPFTLDE EADDGEAVVL TVKVPRFLST
     TLIDVQVEVN YIRVFVKEKL IQVPLSQEVA PSGVNVQRSS VNGELRIRIP YAPHVLQEVS
     EARRRRQRLL GLLSDDKNED GTG