DAA11_XENTR
ID DAA11_XENTR Reviewed; 470 AA.
AC Q28FY0; Q6P345;
DT 25-JAN-2012, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Dynein axonemal assembly factor 11 {ECO:0000305};
DE Short=DNAAF11 {ECO:0000305};
DE AltName: Full=Leucine-rich repeat-containing protein 6;
DE AltName: Full=Protein tilB homolog;
GN Name=dnaaf11; Synonyms=lrrc6; ORFNames=TGas012h22.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula;
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=20431018; DOI=10.1126/science.1183670;
RA Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT "The genome of the Western clawed frog Xenopus tropicalis.";
RL Science 328:633-636(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-470.
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in dynein arm assembly, is important for expression
CC and transporting outer dynein arm (ODA) proteins from the cytoplasm to
CC the cilia. {ECO:0000250|UniProtKB:Q86X45}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q86X45}. Cell
CC projection, cilium {ECO:0000250|UniProtKB:Q86X45}. Dynein axonemal
CC particle {ECO:0000250|UniProtKB:A0A1L8G016}. Cell projection, cilium,
CC flagellum {ECO:0000250|UniProtKB:Q86X45}. Note=Localized to cytoplasmic
CC puncta in ciliated cells. In the semicircular canal, localized to
CC kinocilia (By similarity). {ECO:0000250|UniProtKB:B3DH20}.
CC -!- SIMILARITY: Belongs to the tilB family. {ECO:0000305}.
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DR EMBL; CR761682; CAJ83438.1; -; mRNA.
DR EMBL; AAMC01093643; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01093644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01093645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01093646; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01093647; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01093648; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01093649; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01093650; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01093651; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01093652; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01093653; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AAMC01093654; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC064188; AAH64188.1; -; mRNA.
DR RefSeq; NP_001032332.1; NM_001037255.1.
DR AlphaFoldDB; Q28FY0; -.
DR SMR; Q28FY0; -.
DR STRING; 8364.ENSXETP00000049805; -.
DR PaxDb; Q28FY0; -.
DR PRIDE; Q28FY0; -.
DR Ensembl; ENSXETT00000049805; ENSXETP00000049805; ENSXETG00000023039.
DR GeneID; 394985; -.
DR KEGG; xtr:394985; -.
DR CTD; 23639; -.
DR Xenbase; XB-GENE-946667; dnaaf11.
DR eggNOG; KOG0531; Eukaryota.
DR HOGENOM; CLU_034806_0_1_1; -.
DR InParanoid; Q28FY0; -.
DR OMA; QHRAVIV; -.
DR OrthoDB; 800324at2759; -.
DR PhylomeDB; Q28FY0; -.
DR TreeFam; TF324815; -.
DR Proteomes; UP000008143; Chromosome 6.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000023039; Expressed in testis and 12 other tissues.
DR ExpressionAtlas; Q28FY0; differential.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0031514; C:motile cilium; IEA:UniProtKB-SubCell.
DR GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR GO; GO:0090660; P:cerebrospinal fluid circulation; ISS:UniProtKB.
DR GO; GO:0060287; P:epithelial cilium movement involved in determination of left/right asymmetry; ISS:UniProtKB.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; ISS:UniProtKB.
DR GO; GO:0051649; P:establishment of localization in cell; ISS:UniProtKB.
DR GO; GO:0030317; P:flagellated sperm motility; ISS:UniProtKB.
DR GO; GO:0036158; P:outer dynein arm assembly; ISS:UniProtKB.
DR GO; GO:0061512; P:protein localization to cilium; ISS:UniProtKB.
DR GO; GO:0120229; P:protein localization to motile cilium; ISS:UniProtKB.
DR Gene3D; 3.80.10.10; -; 1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR003603; U2A'_phosphoprotein32A_C.
DR SMART; SM00446; LRRcap; 1.
DR PROSITE; PS51450; LRR; 4.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Coiled coil; Cytoplasm; Flagellum;
KW Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..470
FT /note="Dynein axonemal assembly factor 11"
FT /id="PRO_0000414860"
FT REPEAT 20..43
FT /note="LRR 1"
FT REPEAT 44..65
FT /note="LRR 2"
FT REPEAT 66..89
FT /note="LRR 3"
FT REPEAT 90..110
FT /note="LRR 4"
FT DOMAIN 128..146
FT /note="LRRCT"
FT DOMAIN 303..395
FT /note="CS"
FT REGION 182..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 447..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 177..288
FT /evidence="ECO:0000255"
FT COMPBIAS 182..211
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..236
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 470 AA; 54621 MW; B40A3F39E360F545 CRC64;
MVRVSEDLIR RRAEHNNCEI FSLEEISLHQ QDLERIEYID KWCRELKILY LQNNLIGKIE
NVSKLKKLEY LNLALNNIEK IENLEGCESL QKLDLTVNFV GDLSSINSLQ ENRQLREFYL
VGNPCAEYEG YRQYVVATLP QLKWLDGKEI ERSERIQAAQ DYPQVQGKIK EQEEAYLRKR
AAEREKATNN LQQKQKEGRK AQEKKPGFDR RWYTDINNTI PDPVEKTDTV AQLNVDETAL
RNDDEEEEKE FWNQPSQYTP ESRLETHRYL EEKRKSKENR SEEELKKKPP RTLITAEGRV
LNVNESKLDF SLVDDEENNQ FVLDLAIYRH LDTSLLDVDV QPGYIKVLVK EKPFQLVLPA
EVKPDSSAAK RSQTTGHLVV TMPKATEMIQ TKRAKSPAIA ERTCKNPQKC LKTHEKLEVD
PKARSIPDVA NIVQEKKTWA QGPLRLHRNS ARDTADSEDF IDNAEVPPLV
