DAAF1_AEDAE
ID DAAF1_AEDAE Reviewed; 1107 AA.
AC Q16RY9;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 25-MAY-2022, entry version 90.
DE RecName: Full=Dynein axonemal assembly factor 1 homolog;
DE AltName: Full=Leucine-rich repeat-containing protein 50;
GN ORFNames=AAEL010772;
OS Aedes aegypti (Yellowfever mosquito) (Culex aegypti).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Culicinae; Aedini; Aedes; Stegomyia.
OX NCBI_TaxID=7159;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LVPib12;
RX PubMed=17510324; DOI=10.1126/science.1138878;
RA Nene V., Wortman J.R., Lawson D., Haas B.J., Kodira C.D., Tu Z.J.,
RA Loftus B.J., Xi Z., Megy K., Grabherr M., Ren Q., Zdobnov E.M., Lobo N.F.,
RA Campbell K.S., Brown S.E., Bonaldo M.F., Zhu J., Sinkins S.P.,
RA Hogenkamp D.G., Amedeo P., Arensburger P., Atkinson P.W., Bidwell S.L.,
RA Biedler J., Birney E., Bruggner R.V., Costas J., Coy M.R., Crabtree J.,
RA Crawford M., DeBruyn B., DeCaprio D., Eiglmeier K., Eisenstadt E.,
RA El-Dorry H., Gelbart W.M., Gomes S.L., Hammond M., Hannick L.I.,
RA Hogan J.R., Holmes M.H., Jaffe D., Johnston S.J., Kennedy R.C., Koo H.,
RA Kravitz S., Kriventseva E.V., Kulp D., Labutti K., Lee E., Li S.,
RA Lovin D.D., Mao C., Mauceli E., Menck C.F., Miller J.R., Montgomery P.,
RA Mori A., Nascimento A.L., Naveira H.F., Nusbaum C., O'Leary S.B., Orvis J.,
RA Pertea M., Quesneville H., Reidenbach K.R., Rogers Y.-H.C., Roth C.W.,
RA Schneider J.R., Schatz M., Shumway M., Stanke M., Stinson E.O.,
RA Tubio J.M.C., Vanzee J.P., Verjovski-Almeida S., Werner D., White O.R.,
RA Wyder S., Zeng Q., Zhao Q., Zhao Y., Hill C.A., Raikhel A.S., Soares M.B.,
RA Knudson D.L., Lee N.H., Galagan J., Salzberg S.L., Paulsen I.T.,
RA Dimopoulos G., Collins F.H., Bruce B., Fraser-Liggett C.M., Severson D.W.;
RT "Genome sequence of Aedes aegypti, a major arbovirus vector.";
RL Science 316:1718-1723(2007).
CC -!- FUNCTION: Cilium-specific protein required for cilia structures.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNAAF1 family. {ECO:0000305}.
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DR EMBL; CH477692; EAT37220.1; -; Genomic_DNA.
DR RefSeq; XP_001654892.1; XM_001654842.1.
DR AlphaFoldDB; Q16RY9; -.
DR SMR; Q16RY9; -.
DR STRING; 7159.AAEL010772-PA; -.
DR PRIDE; Q16RY9; -.
DR GeneID; 5573861; -.
DR KEGG; aag:5573861; -.
DR VEuPathDB; VectorBase:AAEL010772; -.
DR eggNOG; ENOG502QQFE; Eukaryota.
DR HOGENOM; CLU_282320_0_0_1; -.
DR InParanoid; Q16RY9; -.
DR OMA; ANIMEDY; -.
DR OrthoDB; 184223at2759; -.
DR PhylomeDB; Q16RY9; -.
DR Proteomes; UP000008820; Chromosome 2.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0036159; P:inner dynein arm assembly; IEA:InterPro.
DR GO; GO:0036158; P:outer dynein arm assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR027734; DNAAF1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973:SF19; PTHR45973:SF19; 1.
DR PROSITE; PS51450; LRR; 5.
PE 3: Inferred from homology;
KW Cell projection; Cilium; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..1107
FT /note="Dynein axonemal assembly factor 1 homolog"
FT /id="PRO_0000363934"
FT REPEAT 34..56
FT /note="LRR 1"
FT REPEAT 57..78
FT /note="LRR 2"
FT REPEAT 79..100
FT /note="LRR 3"
FT REPEAT 101..122
FT /note="LRR 4"
FT REPEAT 125..146
FT /note="LRR 5"
FT REPEAT 150..171
FT /note="LRR 6"
FT DOMAIN 184..223
FT /note="LRRCT"
FT REGION 258..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..608
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 780..810
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 834..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1070..1107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 473..487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..518
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..535
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..561
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 579..597
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1070..1101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1107 AA; 126556 MW; 113F398DE3556929 CRC64;
MVRECVEESF GPKKMTKKSI VDSCKKNKLY ITPHLNDILY LNYSGYNAIE SLEEYVGLKC
LWLECNAISE IKGLEYQTEL KCLYLQNNLI TKIENLDSCK QLDTLNLSHN HITRIENCGH
DILPVLNTLN LSHNYLKTAD NLDHLRHCNF VSVLDLSHNR IEDIAIVKIL GGMKELRVLT
MTGNPVVNEI PSYRKTLILE CKNLTYLDTR PVFDRDRACA EAWKRGGYEE ERKELLRWKK
EEQRKIRRSI NATLRMRHRG DGEPELLKTS SDEEDEDKAS KCGKDMSSML EINQKTNEQA
WAEVEKMFCT TPSATGSSGI FQRFATNRGG GADGDGEVIE TSEEDIEATI EDIKAVSPKK
LIEEISSDSD GAKENYDCKP DEVIAKPCSE KLIEEIVIET AECDSGPSSP EYHEALDKPI
ENIVNLTNES PLTSPSFDTE PRTLIEEIEP TDVEEEQQIE EQPAPKPLSK NMEKVMSTEK
EDDTLNVLIE NNEEISITME SKDGELISKV ESRPPSTECK KYKIVSTNDV DNSESEPTDI
TNEDQEYRSS SVSVTSSTDS SDSEDLFDKI VPNKHPKLAT NYRQDSTTST DSENEVSPSK
PPIKLEKEKS IAECIDEYKK FFKAAKILES DPEDESSTKM ARPHTAKAKR TEPIIYEGVL
RNMERNSNES KIAEARTEAK ESKEKVIDRL IEQQNLVDMN LEEQNISIGG QEHDFNEYRL
EAFRKDQEKL QCLIDRVTAQ KDLYNAHIDQ IHNQLANIME DYDQIGLKLK KVDDFLENIK
EEPKAPETPS IESEEEIPEE LEVHSSEHEQ EIVENDNLAQ QIIEKIISQS VKTSSEDLKS
NFDDSSESSD SAEEDFMDSI RPDHNLLEIL TSPKPIPILD PELIPNVDNE FQRDPVYRKF
IEIQEEIDKL TEDELYDIVT EATGEFSEEA HVEHCLNTQV DQYWKQYDDI EEFRKNINLD
SHPIIQKFRQ FIRCHCENKY PGEVDSTIDN LDKACRKLER RLSNQLFDEY LELSRKMSVA
TIGGESSANE IELIEVDEEE NDVEDVVKKI TAWVEEQVQN EIAELNEERA AHAGEVMQDT
EDVESKPVEI DGTKEETVDS ELADNCD
