DAAF1_ANOGA
ID DAAF1_ANOGA Reviewed; 910 AA.
AC Q7PK92;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 09-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Dynein axonemal assembly factor 1 homolog;
DE AltName: Full=Leucine-rich repeat-containing protein 50;
GN ORFNames=AGAP009594;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- FUNCTION: Cilium-specific protein required for cilia structures.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNAAF1 family. {ECO:0000305}.
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DR EMBL; AAAB01008980; EAA43462.2; -; Genomic_DNA.
DR RefSeq; XP_318616.2; XM_318616.2.
DR AlphaFoldDB; Q7PK92; -.
DR SMR; Q7PK92; -.
DR STRING; 7165.AGAP009594-PA; -.
DR PaxDb; Q7PK92; -.
DR PRIDE; Q7PK92; -.
DR GeneID; 1278959; -.
DR KEGG; aga:AgaP_AGAP009594; -.
DR CTD; 1278959; -.
DR VEuPathDB; VectorBase:AGAP009594; -.
DR eggNOG; ENOG502QQFE; Eukaryota.
DR HOGENOM; CLU_282320_0_0_1; -.
DR InParanoid; Q7PK92; -.
DR OMA; ANIMEDY; -.
DR OrthoDB; 184223at2759; -.
DR PhylomeDB; Q7PK92; -.
DR Proteomes; UP000007062; Chromosome 3R.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR GO; GO:0035082; P:axoneme assembly; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0036159; P:inner dynein arm assembly; IEA:InterPro.
DR GO; GO:0036158; P:outer dynein arm assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR027734; DNAAF1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973:SF9; PTHR45973:SF9; 1.
DR PROSITE; PS51450; LRR; 6.
PE 3: Inferred from homology;
KW Cell projection; Cilium; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..910
FT /note="Dynein axonemal assembly factor 1 homolog"
FT /id="PRO_0000363935"
FT REPEAT 43..64
FT /note="LRR 1"
FT REPEAT 65..86
FT /note="LRR 2"
FT REPEAT 87..108
FT /note="LRR 3"
FT REPEAT 111..132
FT /note="LRR 4"
FT REPEAT 136..157
FT /note="LRR 5"
FT DOMAIN 171..209
FT /note="LRRCT"
FT REGION 217..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 297..332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 344..399
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..642
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 662..682
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 855..910
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 351..374
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 377..394
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..634
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 867..894
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 910 AA; 104016 MW; 52D42E9491ECE0C7 CRC64;
MTKKTIQASC RKNKLYLTPH LNDVLYLHYS GYNAIDGLDE YVGLKCLWLE CNAISNISGL
DHQSQLRCLY LHNNLIKKIE NLQHCKQLDT LNLSHNHIAK IENCGSDILP VLNTLNISHN
YLKSIESLAE LRKCDFVSVL DISHNRIEDI AIVKVLADMK GLRVLTLVGN PVVNDIPSYR
KTLILECKSL TYLDSRPVFD KDRACAEAWK RGGYEEERKE HQRWKKEEQR KMRRSINATL
RLRHRGDGEP ELLKTSSDEE EEEKEGSAAG RGDFEELEYQ SNDVAWKEME ALFNQHTKGD
TQQAQKLAEE RKASTNSVDY ITGSDSNSDP TLVTDCDSCV RNSSRACSSR SDTSDSEDMF
DKIVPKKHRK LASSMRPEVS LSDSSSSSSE TEDEAGSILD SKLDRQNTIT EFIDEYKRFF
HSVDLRDPKC VLKNRHKIVR PQTAKSQRTE PIVYEGVLKA MEQNSNGAKI EQARQERFEA
NERSLAKEAV LERLMKGHAE VDMNIEQQMI SIGGKQHNFN EYRLEVFRQD QEKLQNLIDR
VTAQKEKYNA HIDSIHDQLA NIMEDYGQIS EKLRKVDDMI QNIGDEVVVH QEKERDGLEV
IQELEPITIA EQIVENMTKE QVPDEVEAND KASDATIDPV DQLSSDESAI DLGELNQHVD
AQVEVGPSDP KDATTSKPIP EEFGSDPVYR KFIDIQYEID KLTEDQIFTA LSEAARELQE
EELETKLVHD AIDEYWSTDL EDFRRNLNLD AHPIVQRFKR FIECQGTDTD DTDSEAHVRR
LENAYHRYER RLSNHLFDEY LMLSRKASIA TTTGGESSAT ELELVELDGG HVLRASTSRR
ATAWDLKETV EDPVEELEEL NEEEDPALKE AGDFKHDELE DEESKPEEKT LKSAEVLGMQ
EPLADVQGDH
