ID   DAAF1_DROER             Reviewed;        1503 AA.
AC   B3NLX1;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 67.
DE   RecName: Full=Dynein axonemal assembly factor 1 homolog;
DE   AltName: Full=Defective transmitter-recycling protein;
DE   AltName: Full=Leucine-rich repeat-containing protein 50 homolog;
GN   Name=dtr; ORFNames=GG21300;
OS   Drosophila erecta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7220;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 14021-0224.01;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Cilium-specific protein required for cilia structures.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNAAF1 family. {ECO:0000305}.
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DR   EMBL; CH954179; EDV54437.1; -; Genomic_DNA.
DR   RefSeq; XP_001974037.1; XM_001974001.2.
DR   AlphaFoldDB; B3NLX1; -.
DR   SMR; B3NLX1; -.
DR   STRING; 7220.FBpp0139846; -.
DR   EnsemblMetazoa; FBtr0141354; FBpp0139846; FBgn0113479.
DR   GeneID; 6548898; -.
DR   KEGG; der:6548898; -.
DR   eggNOG; ENOG502QQFE; Eukaryota.
DR   HOGENOM; CLU_001523_0_0_1; -.
DR   OMA; WKREGYE; -.
DR   OrthoDB; 162620at2759; -.
DR   PhylomeDB; B3NLX1; -.
DR   ChiTaRS; Trxr-1; fly.
DR   Proteomes; UP000008711; Unassembled WGS sequence.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:EnsemblMetazoa.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0036159; P:inner dynein arm assembly; IEA:InterPro.
DR   GO; GO:0036158; P:outer dynein arm assembly; IEA:InterPro.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR027734; DNAAF1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR45973:SF9; PTHR45973:SF9; 1.
DR   PROSITE; PS51450; LRR; 6.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Leucine-rich repeat; Repeat.
FT   CHAIN           1..1503
FT                   /note="Dynein axonemal assembly factor 1 homolog"
FT                   /id="PRO_0000363936"
FT   REPEAT          34..56
FT                   /note="LRR 1"
FT   REPEAT          57..78
FT                   /note="LRR 2"
FT   REPEAT          79..100
FT                   /note="LRR 3"
FT   REPEAT          101..122
FT                   /note="LRR 4"
FT   REPEAT          125..146
FT                   /note="LRR 5"
FT   REPEAT          150..171
FT                   /note="LRR 6"
FT   DOMAIN          185..223
FT                   /note="LRRCT"
FT   REGION          249..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          305..328
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          956..1033
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1295..1315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        252..269
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        307..322
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        986..1033
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1503 AA;  171339 MW;  5C1C4772896998E2 CRC64;
     MSHANRKEIT GLTRMTPKGL KELCKKDKLY QTPRLNDVLY LHYQGFQCIE NLEEYTELKC
     LWLECNAISE IQGLEKLGKL KCLFLQNNLI TKIENLDPCR ELDTLNLSSN HIRKIQNIGT
     NILPVLNTLT IASNYLKDSD SLSDLIQCKT LSVLDLSNNR IDDILIVKIF EQMVSLKVLV
     LQGNPVVSRL PQYRKTLILA CKELTYLDSR PVFPRDRACA EAWKRDGYEG ERKENNRWKR
     AERRKTRESI NCTIRMRNSH RPPDQQDPLL RSSDSEDDTC TETTRKKVAL ENDCVDDLWE
     EVSCEQPISD HGTSTSSSVE DKDGTSSQDD LIAEKLSNRG TLEGRPTVLY ENEVSNIKSV
     NQNIKNFEPR SIETKVFQDV SKISPIIIEE KRVPNINLNN EPSDVKNRKV IKCEKTGYTS
     TGQVLKENVF DEDAEIKNVE DMVQCQDIIK SNEDMNSEFV VSTKLEKDVE QTCIALRNEA
     QCKELDEDQS IKEIESKLIN EMYENVAADD HDKHNETVDL NLKKTASAQH ARTFFFEENK
     MTRRFYQEDK KSSLLAKSKE EALLEEDCII SNEKCAYDLE EIGRQMEEDL AELRQSTQKL
     VGFSIDEDAD SKTDSEIDEE DLMAQQDPYS PLLQQQFKDR RMKIMLKEET KAQGESIRDL
     NITLSNESSS DDKQDQLFAK LLDDATENIP KRIFGTGCDS LSSAWPQEEC LLQLTLSEVK
     ETPDQEIVFK NSITNSSSFE EANEICVRID QKMAEEEAAL GKLLHDLENE ANTKVKHDET
     NSSKESDAAR ICTSLLDDIM VELTFNEKRW HEKPKSFKFG PIESDDEFSY SFEPQLEKLV
     PPALEDPARG KSLRECLDTF SDFVSSMADP KLPLMLGRNP TSGVEKIRAA QELLKSKNLA
     ELYADTAESL NSQVAKEIEK RKRRVAASAT RCFNQRDKYD DTLELVQNRL MIVKKDSGDL
     EELPPPPPLI SDTESEDYDT AEDEYTPGNG GHKHTHGSKP QDSKEHLMNN LLKQKQDKPD
     TVEEVGKKND HDEDEFYSLE AMTTFGNLDA EFFHKLDLQK VNDSEDSESA INCMRSYNEL
     QAYMKSGSLK HQLNSEDTKM LQTMFSTVAS DGKPKLRNPK GEEEDDLLKK MVLRMKEYEE
     REHQLQLVPH EIPRELSPIK LSLGGSKLFE QKNKIPETGL VHAENELTGN IQFIDNKKTN
     NDKSTDAIEK NCEPLVKTSC QTSNKSIDDD IQSDVSTDYE SGEEVLVVEP PKLSDAVLKS
     LYSDGFEADL KMVHELEEAT RRNLYRYHSN VMHNSTNNHS FSTKKTLPTK TSTSEQSVGA
     KAKWAKIAER LHEFLDPETI LRKEQIGERD ACEDSEDEDF AFEENNFEKD EKLIISEEYN
     STQNICDGNS GPSKLDGSDQ FASIKGFENI TEMPTYNMEL NSQSKKKTSE KLSNEIENII
     TTCSSFEAPT DSIGIEYFED PTLTQINPEG LKTEQIECNL QILNEDGDVV VQELSVNAQV
     SFE