ID   DAAF1_DROPE             Reviewed;        1501 AA.
AC   B4GT53;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   23-SEP-2008, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Dynein axonemal assembly factor 1 homolog;
DE   AltName: Full=Defective transmitter-recycling protein;
DE   AltName: Full=Leucine-rich repeat-containing protein 50 homolog;
GN   Name=dtr; ORFNames=GL26663;
OS   Drosophila persimilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7234;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSH-3 / Tucson 14011-0111.49;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Cilium-specific protein required for cilia structures.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DNAAF1 family. {ECO:0000305}.
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DR   EMBL; CH479189; EDW25562.1; -; Genomic_DNA.
DR   RefSeq; XP_002021719.1; XM_002021683.1.
DR   AlphaFoldDB; B4GT53; -.
DR   SMR; B4GT53; -.
DR   STRING; 7234.FBpp0190770; -.
DR   PRIDE; B4GT53; -.
DR   EnsemblMetazoa; FBtr0192278; FBpp0190770; FBgn0164244.
DR   eggNOG; ENOG502QQFE; Eukaryota.
DR   HOGENOM; CLU_001523_0_0_1; -.
DR   OMA; WKREGYE; -.
DR   PhylomeDB; B4GT53; -.
DR   ChiTaRS; Trxr-1; fly.
DR   Proteomes; UP000008744; Unassembled WGS sequence.
DR   GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR   GO; GO:0007268; P:chemical synaptic transmission; IEA:EnsemblMetazoa.
DR   GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR   GO; GO:0036159; P:inner dynein arm assembly; IEA:InterPro.
DR   GO; GO:0036158; P:outer dynein arm assembly; IEA:InterPro.
DR   Gene3D; 3.80.10.10; -; 2.
DR   InterPro; IPR027734; DNAAF1.
DR   InterPro; IPR001611; Leu-rich_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   PANTHER; PTHR45973:SF19; PTHR45973:SF19; 1.
DR   PROSITE; PS51450; LRR; 6.
PE   3: Inferred from homology;
KW   Cell projection; Cilium; Leucine-rich repeat; Reference proteome; Repeat.
FT   CHAIN           1..1501
FT                   /note="Dynein axonemal assembly factor 1 homolog"
FT                   /id="PRO_0000363938"
FT   REPEAT          38..60
FT                   /note="LRR 1"
FT   REPEAT          61..82
FT                   /note="LRR 2"
FT   REPEAT          83..104
FT                   /note="LRR 3"
FT   REPEAT          105..126
FT                   /note="LRR 4"
FT   REPEAT          129..150
FT                   /note="LRR 5"
FT   REPEAT          154..175
FT                   /note="LRR 6"
FT   DOMAIN          189..227
FT                   /note="LRRCT"
FT   REGION          245..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          508..531
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          808..827
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          862..891
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1021..1086
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1100..1175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1260..1294
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1307..1379
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1402..1436
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1448..1468
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        245..266
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..302
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        308..333
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1024..1078
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1270..1294
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1320..1345
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1346..1375
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1402..1435
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1501 AA;  170954 MW;  9400FDD19096E2D9 CRC64;
     MCEPGFARRR EEVTGLNRIT EKGLKDICKR DKLYQTPRLN DVLYLHFQGY QCIENLDEYT
     ELKSLWLESN AISEIQNLTK LTKLKCLYLQ NNLITKMENL EFNRELDTLN LSQNHIRKIE
     NIGTDILPVL NTLNITSNYL TDSASLAALV ECKTLSVLDL SNNRIDDILI VKIFEQMPSL
     KVLVLQGNPV VSRLPQYRKT LILACKELTY LDSRPVFPRD RACAEAWKRE GYEGERKEVQ
     RWNRAERRKT RESVNSTIRM RNRHLKPENQ VPLLTSSDSE EEQKGISSAE KAQKRAEMEY
     GSVDTMWDEV SGESQASEHS TTSSTSAEDN ESAGSQADHI AERISNRRVK PLEGRPKVLY
     DEAASGDVDS IVKLVTNKEE NEQKDQNISE IEEQHKGKIV FIEEMNENQN ASMGNQKAVS
     EAVETIGKPV AVDVNNTLSN SIVEPVNEQN NLASDQMEHL KGKRILIEKV DDIDPIKKEL
     KYFDEAMQNK ELKQTSELEE LRDFTENLSS DVQEQAKDPS ESDEEPTEEE MEVKSQLLKE
     QFQDRKQRLK EAIEERKTMQ KNLEARKEDL NKSYNLFAKI MDDATDNVPK RVFGAGCDMP
     SKDWDKEECM QQLPLTSMED SINGRPSSND EDILTRPLTE LTSAEAAEEI CSQLDRKLAG
     EEAALRQLLC DLENENEILY SIETQIKYAE SISVEDSQSQ MVCASLLNDL ISDVIYKDIT
     EMGPNSYPLG PIESDEEYTY SEEPKLEKMV PPHLENPAGG KSLRECVDTF KEFFASKGND
     KPRQESHTHL EKIRAAKALL KSKSLAEFSK DTPESLDAQL AKDEDRRKRH VAASAGRCFA
     KREKYDDTLE VVDNRLMVVK KDTGELEELP PPPELISDSE SEKEVEEDDD AYDTAEETLQ
     EYPRVPWTTP YKPKPRKAAE HLVNEAMQRI LAEQFSELPD DTKENEPQED EFFSLEAKET
     FGNLDSEFFQ KLDLDKVTTA NNAEAATECM RSYNELKACM KSGSTELQLT SEENEMLQEM
     LSSNEDLEAK HKSNDDPLVE RDNELLNKMM QRMKEHEERA RELQEQLEKE KEEENSGPIK
     LSMGEGSMLY QRWSPLSLTE IIDPQAEEGG RQAEEGGAQQ EEGGAQSEER DDQAEGVPQA
     EEGVTQGEES VLQEEETHAE NGVAQAEGRV LQSPEIYPII GYEDIDDDDA ASDFTTDYSS
     DDEVAVVVPP KISPAMLKAY YYDGFEEDMR MVRENEARTR RGLRAIMQKE KQMWKDNEEM
     AADMAPSPSP KEEHIPEVKT ETETAKPTVE TAKDKWAKIA SRLNEFLDPE AMEQLESHEF
     GESDGEDDVD LTGLQNYDEE SETECESALK ETAEIGDSEK QENKTQDETL DPKDTEAITD
     VTLGIQRLKR QKLICQWEKI IPEDSKIGDG PTEKFLDQKA QDNPETTDER PENPKNFITL
     DYFVDTEPSE SLEDTEATET PEVSTEQTLK TEQMEFNLDV LNDDGDVVIK EVTVEAQVTY
     Q