DAAF1_DROPS
ID DAAF1_DROPS Reviewed; 1582 AA.
AC Q29KL8;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 14-OCT-2008, sequence version 2.
DT 03-AUG-2022, entry version 83.
DE RecName: Full=Dynein axonemal assembly factor 1 homolog;
DE AltName: Full=Defective transmitter-recycling protein;
DE AltName: Full=Leucine-rich repeat-containing protein 50 homolog;
GN Name=dtr; ORFNames=GA16341;
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MV2-25 / Tucson 14011-0121.94;
RX PubMed=15632085; DOI=10.1101/gr.3059305;
RA Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA Weinstock G.M., Gibbs R.A.;
RT "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT gene, and cis-element evolution.";
RL Genome Res. 15:1-18(2005).
CC -!- FUNCTION: Cilium-specific protein required for cilia structures.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNAAF1 family. {ECO:0000305}.
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DR EMBL; CH379061; EAL33156.2; -; Genomic_DNA.
DR AlphaFoldDB; Q29KL8; -.
DR SMR; Q29KL8; -.
DR STRING; 7237.FBpp0287855; -.
DR eggNOG; ENOG502QQFE; Eukaryota.
DR HOGENOM; CLU_001523_0_0_1; -.
DR InParanoid; Q29KL8; -.
DR OMA; WKREGYE; -.
DR ChiTaRS; Trxr-1; fly.
DR Proteomes; UP000001819; Genome assembly.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0036159; P:inner dynein arm assembly; IEA:InterPro.
DR GO; GO:0036158; P:outer dynein arm assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR027734; DNAAF1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973:SF19; PTHR45973:SF19; 1.
DR PROSITE; PS51450; LRR; 6.
PE 3: Inferred from homology;
KW Cell projection; Cilium; Leucine-rich repeat; Reference proteome; Repeat.
FT CHAIN 1..1582
FT /note="Dynein axonemal assembly factor 1 homolog"
FT /id="PRO_0000363939"
FT REPEAT 38..60
FT /note="LRR 1"
FT REPEAT 61..82
FT /note="LRR 2"
FT REPEAT 83..104
FT /note="LRR 3"
FT REPEAT 105..126
FT /note="LRR 4"
FT REPEAT 129..150
FT /note="LRR 5"
FT REPEAT 154..175
FT /note="LRR 6"
FT DOMAIN 189..227
FT /note="LRRCT"
FT REGION 245..420
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 560..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 859..878
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 913..942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1073..1092
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1150..1218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1305..1345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1358..1438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1484..1517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1529..1548
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 245..268
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 283..302
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 341..364
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 371..390
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 395..420
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1075..1092
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1101..1129
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1321..1345
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1371..1396
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1397..1429
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1484..1516
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1582 AA; 180080 MW; 7211B273760460EC CRC64;
MCERGFARRR EEVTGLNRIT EKGLKDICKR DKLYQTPRLN DVLYLHFQGY QCIENLDEYT
ELKSLWLESN AISEIQNLTK LTKLKCLYLQ NNLITKMENL EFNRELDTLN LSQNHIRKIE
NIGTDILPVL NTLNITSNYL TDSASLAALV ECKTLSVLDL SNNRIDDILI VKIFEQMPSL
KVLVLQGNPV VSRLPQYRKT LILACKELTY LDSRPVFPRD RACAEAWKRE GYEGERKEVQ
RWNRAERRKT RESVNSTIRM RNRHLKPEDQ VPLLTSSDSE EEQKGISSAE KAQKRAEMEY
GSVDTMWDEV SGESQASEHS TTSSTSAEDN ESAGSQADHI AERISNRRVK PLEGRPKVLY
DEAASGDEKA VTTTDSKKDS NAEDLPELKD ITEALLQSDT ASKPPLQPTL LQSDSGSEMD
NTADLEQTCQ TLLQVAQGND DGDPTPKQIK SQMIDEMYES FGSDLFEEHP LPIDQLLNES
TKKYQLEAKV CCEEETTKTP RDLYKEFIEE VTWRPKSKEQ LEREQECVDA SEKCAHDLAE
MGSHLEEDLQ ELRDFTENLS SDVQEQAKDP SESDEEPTEE EMEVKSQLLK EQFQDRKKRL
KEAIEERKTM QKNLEARKED LNKSYNLFAK IMDDATDNVP KRVFGAGCDV PSKDWDKEEC
MQQLPLTSME DSINGRPSSN DEDILTRPLT ELTSAEAAEE ICSQLDRKLA GEEEALRQLL
CDLENENEIL YSIETQIKYA ESISVEDSQS QMVCASLLND LISDVIYKDI TEMGPNSYPL
GPIESDEEYT YSEEPKLEKM VPPHLENPAG GKSLRECVDT FKEFFASKGN DKPRQESHTH
LEKIRAAKAL LKSKSLAEFS KDTPESLDAQ LAKDEDRRKR HVAASAGRCF AKREKYDDTL
EVVDNRLMVV KKDTGELEEL PPPPELISDS ESEKEVEEDD DAYDTAEETL QEYPRVPWTT
PYKPKPRKAA EHLVNEAMQR VLAEQFSELP DDTKENEPQE DEFFSLEAKE TFGNLDSEFF
QKLDLDKVTT ANNAEAATEC MRSYNELKAC MKSGSTELQL TSEENEMLQE MLSSNEDLEA
KHKSNDDPLV ERDNELLNKM MQRMKEHEER ARELQEQLEK EKEEENSGPI KLSMGEGSML
YQRWSPLSLT EIIDPQAEEG GRQAEEGGAQ QEEGGAQSEE GDDQAGVPQA EEGVTQGEES
VLQEEETHAE NGVAQAEGRV LQSPVIYPII GYEDIDDDDA ASDFTTDYSS DDEVAVVVPP
KISPAMLKAY YYDGFEEDMR MVRENEARTR RGLRAIMQKE KQMWKDNEEE MAADMAPSAS
PKEEHIPEVK SETETAKPTV ETAKDKWAKI ASRLNEFLDP EAMEQLESHE FGESDGEDDV
DLTGLQNYDE ESETECESAL KETTEIGDSE KQENKTQDET LDPKDTEAIT DEWSPYQTSF
EENRTAFCDR HNKLTMITEQ TSDVGDPETE TTKLICQWEK IIPEDSKIGD GPTEKFLDQK
AQDNTENTDE RPENPKNFIT LDYFVDTEPS ESLEDTEATE TPEVSTEQTL KTEQMEFNLD
VLNDDGDVVI KEVTVEAQVT YQ
