DAAF1_DROYA
ID DAAF1_DROYA Reviewed; 1509 AA.
AC B4P6W7;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 23-SEP-2008, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Dynein axonemal assembly factor 1 homolog;
DE AltName: Full=Defective transmitter-recycling protein;
DE AltName: Full=Leucine-rich repeat-containing protein 50 homolog;
GN Name=dtr; ORFNames=GE12915;
OS Drosophila yakuba (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7245;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tai18E2 / Tucson 14021-0261.01;
RX PubMed=17994087; DOI=10.1038/nature06341;
RG Drosophila 12 genomes consortium;
RT "Evolution of genes and genomes on the Drosophila phylogeny.";
RL Nature 450:203-218(2007).
CC -!- FUNCTION: Cilium-specific protein required for cilia structures.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell projection, cilium {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DNAAF1 family. {ECO:0000305}.
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DR EMBL; CM000158; EDW89936.1; -; Genomic_DNA.
DR RefSeq; XP_002090224.1; XM_002090188.2.
DR AlphaFoldDB; B4P6W7; -.
DR SMR; B4P6W7; -.
DR STRING; 7245.FBpp0257925; -.
DR EnsemblMetazoa; FBtr0259433; FBpp0257925; FBgn0230630.
DR GeneID; 6529217; -.
DR KEGG; dya:Dyak_GE12915; -.
DR eggNOG; ENOG502QQFE; Eukaryota.
DR HOGENOM; CLU_001523_0_0_1; -.
DR OMA; WKREGYE; -.
DR OrthoDB; 162620at2759; -.
DR PhylomeDB; B4P6W7; -.
DR ChiTaRS; Trxr-1; fly.
DR Proteomes; UP000002282; Chromosome 2R.
DR GO; GO:0005930; C:axoneme; ISS:UniProtKB.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:EnsemblMetazoa.
DR GO; GO:0060271; P:cilium assembly; ISS:UniProtKB.
DR GO; GO:0036159; P:inner dynein arm assembly; IEA:InterPro.
DR GO; GO:0036158; P:outer dynein arm assembly; IEA:InterPro.
DR Gene3D; 3.80.10.10; -; 2.
DR InterPro; IPR027734; DNAAF1.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45973:SF9; PTHR45973:SF9; 1.
DR PROSITE; PS51450; LRR; 6.
PE 3: Inferred from homology;
KW Cell projection; Cilium; Leucine-rich repeat; Repeat.
FT CHAIN 1..1509
FT /note="Dynein axonemal assembly factor 1 homolog"
FT /id="PRO_0000363940"
FT REPEAT 34..56
FT /note="LRR 1"
FT REPEAT 57..78
FT /note="LRR 2"
FT REPEAT 79..100
FT /note="LRR 3"
FT REPEAT 101..122
FT /note="LRR 4"
FT REPEAT 125..146
FT /note="LRR 5"
FT REPEAT 150..171
FT /note="LRR 6"
FT DOMAIN 185..223
FT /note="LRRCT"
FT REGION 252..280
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 306..327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 962..1008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1103..1122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 252..279
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 307..327
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 987..1004
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1103..1117
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1509 AA; 171802 MW; 156D82C6D5F68353 CRC64;
MSLSNRKEIT GLTRMTPKGL KELCKKDKLY QTPRLNDTLY LHYQGFQCIE HLEEYTELKC
LWLECNAISE IQGLEKLSKL KCLFLQNNLI TKIENLEPCR ELDTLNLSSN HIRKIQNIGT
NILPVLNTLT IASNYLKDSE SLSDLVQCKT LSVLDLSNNR IDDILIVKIF EQMLNLKVLV
LQGNPVVSRL PQYRKTLILA CKELTYLDSR PVFPRDRACA EAWKRDGYEG ERKENNRWNR
AERRKTRESI NCTIRIRNSH RPPDQQDPLL RSSDSEDDTC TGTTLKKVAL ENGCVDDIWK
EVSCEHPTSE SGASTSSSVE DNDATSSQDD LIAEKLSNRG TLEGRPKVLN ETEGSNLKRV
NQNIKNVEPR NIQTIVFEED VSKKSQVIIE EENVPKINLI NEPCDLNDKK SIIVKCKKTG
YTSIGPVHKK TVFHEDAEIK KMEDVVLCQD FIKSEEHMSS DFAVNSKLGK DIEQTCTAQR
NEAQCKEFDE DQKIIEIESK LIHEMYESFE ADDDDKLNET FDLNLYETTS EHHAHKVSFD
ENKMPMSCYQ EDKESILLPK SMEETLFEEE CFIANDKCAH DLEEIGRQMD EDLAELRQST
QNVVGLSKDE IAETDIETDE EDLLAQQDPY SPLLKQQFKN RRMKIMLIEE SKAQGESQRD
LNITVSNESG GDDKQDQLFA RILDDATENI PKRIFGTGCD ALSYNWPQEE CLLQLTLSEV
KETPAQESTF KNSITNSSSF EEANKICVHM DQKMAEEEEA LGKLLHDLEN EAEHVYEINT
KMTYEETTSS KEVVSICTSL LDDIIVELTL NEILCHEKPK SFKFGPIESD EEFSYSLEPQ
LEKLVPPALE DPARGKSLRE CLDTFSDFVS SMADPKLPLM LGRNPTLGVE KIRAAQELLK
SKNLAEIYAD SAESLNSQVA KEIEKRKRRV AATATRCFNQ RDKYDDTLEL VNNRLMIVKR
DSGDLEELPP PPPLISDSES EDYDTADDEY TPGKGSHKLG SKPKDSKNLV TNSFLKEKQA
DSDVVEEVVK KNDHAEDEFY SLEAMTTFSS LDAEFFQKLD LQKVNDSEDS EPAINCMRNY
NELQAYMKSG SLNHRMNTEE TKTLQTSFST VGSDEGKTKL RNPQEEKENA LLKKMVLRMK
EYEEREHQLQ LVPHELGSVK LSLGGSKLFE QTPETVLVHT ENEPTSKIKF IDNKKTNNDE
STHLIKNYCE PLVRASCKTS NKSIDDDIQS DVSTDYESGE EVVVVEPPKL SEAVLKSFYS
DGFEADLNMV HELEEATRRN LYCYHSNEML NPTKNHPFSL KKTLSSKTST NEVTVGAKAK
WAKIAERLHE FLDPETISKL NKEQFGESDE FEDSQDANIF TDITFEENNS KKYENLVSEE
CNCTKSIYDE NSCPSELNGN DQFSGLKEIN KDKEMPTSNL ELNSVMIQSK KKTSEILPNE
IGNIIKACSS FEAPPTDPIG IEHFEDPTLT QMNPEFLKTK QIECNLQILS EDGDVVVQEL
SVNAQVSFE
