ID   DAAF3_BOVIN             Reviewed;         544 AA.
AC   F1MLB4; F1MKE1;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   16-NOV-2011, sequence version 2.
DT   03-AUG-2022, entry version 48.
DE   RecName: Full=Dynein axonemal assembly factor 3;
GN   Name=DNAAF3;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19393038; DOI=10.1186/gb-2009-10-4-r42;
RA   Zimin A.V., Delcher A.L., Florea L., Kelley D.R., Schatz M.C., Puiu D.,
RA   Hanrahan F., Pertea G., Van Tassell C.P., Sonstegard T.S., Marcais G.,
RA   Roberts M., Subramanian P., Yorke J.A., Salzberg S.L.;
RT   "A whole-genome assembly of the domestic cow, Bos taurus.";
RL   Genome Biol. 10:R42.01-R42.10(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Hereford;
RX   PubMed=19390049; DOI=10.1126/science.1169588;
RG   The bovine genome sequencing and analysis consortium;
RT   "The genome sequence of taurine cattle: a window to ruminant biology and
RT   evolution.";
RL   Science 324:522-528(2009).
CC   -!- FUNCTION: Required for the assembly of axonemal inner and outer dynein
CC       arms. Involved in preassembly of dyneins into complexes before their
CC       transport into cilia (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:Q32NQ7}.
CC   -!- SIMILARITY: Belongs to the DNAAF3 family. {ECO:0000305}.
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DR   EMBL; DAAA02047752; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AAFC03089060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F1MLB4; -.
DR   STRING; 9913.ENSBTAP00000003267; -.
DR   PaxDb; F1MLB4; -.
DR   eggNOG; ENOG502QT97; Eukaryota.
DR   HOGENOM; CLU_024420_2_1_1; -.
DR   InParanoid; F1MLB4; -.
DR   TreeFam; TF323981; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR039304; DNAAF3.
DR   InterPro; IPR028235; DNAAF3_C.
DR   InterPro; IPR027974; DUF4470.
DR   PANTHER; PTHR22118; PTHR22118; 1.
DR   Pfam; PF14737; DUF4470; 1.
DR   Pfam; PF14740; DUF4471; 1.
PE   3: Inferred from homology;
KW   Cilium biogenesis/degradation; Cytoplasm; Reference proteome.
FT   CHAIN           1..544
FT                   /note="Dynein axonemal assembly factor 3"
FT                   /id="PRO_0000416893"
FT   REGION          328..350
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          448..544
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        490..537
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   544 AA;  59563 MW;  14E5937332DAFFE3 CRC64;
     MTTPAGSGTG FGSVSWWGLS PAVDLQAESP PVDPDSQAET EHETPELNVL LLGSVDGRHL
     LRTLARAALW PRRRFHFYVL ENNLEAVARH ILIFSLALED PEKMGLQERS ETFLEVWGNA
     LLRPPVAAFV RAQAGRLAHL VPEPDRLAEQ LPWLSLGALK FRERDALEAV FRFWAGGEKG
     PEAFPMSRLW DSRLRQYLGS RYDARHGVSD WDLHMKLHDR GARVIHTREF RRWRDTGVAF
     ELRDSSAYHV PNRTLASGRL LSHRGERVAA RGYWGDIATG PFVAFGIEAD DETLLRTSNG
     QPVKTACEIT EHNVAELFRE MAAWGHPRAA EGDPEQVQGG AEGSSEPAAP APEPFTVHFL
     SLDSAHTLHH KSCYMGQFQL LYVACGMVHL LSAELGACVA PGGRLIVELA QFLVDLRQEQ
     LQAFSSRVGE LAQAAGFAPQ LGGKPSDTFA RFYKAGDSAP GHEDPAVESG TPPPEVLAPP
     LEATDPPSED RTQPLESGNP PSEPLKLTSE SQASLLEASV PPTGSQAPKS ENQTVPPETK
     YPIP