DAAF3_DROME
ID DAAF3_DROME Reviewed; 540 AA.
AC A1ZB91; B6IDP0; Q5U0U7;
DT 21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT 06-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=Dynein axonemal assembly factor 3 homolog;
GN ORFNames=CG17669;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Testis;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for the assembly of axonemal inner and outer dynein
CC arms. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Dynein axonemal particle
CC {ECO:0000250|UniProtKB:Q32NQ7}.
CC -!- SIMILARITY: Belongs to the DNAAF3 family. {ECO:0000305}.
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DR EMBL; AE013599; AAF57682.1; -; Genomic_DNA.
DR EMBL; BT016145; AAV37030.1; -; mRNA.
DR EMBL; BT050480; ACJ13187.1; -; mRNA.
DR RefSeq; NP_611336.1; NM_137492.2.
DR AlphaFoldDB; A1ZB91; -.
DR STRING; 7227.FBpp0085901; -.
DR PaxDb; A1ZB91; -.
DR PRIDE; A1ZB91; -.
DR DNASU; 37125; -.
DR EnsemblMetazoa; FBtr0086722; FBpp0085901; FBgn0034352.
DR GeneID; 37125; -.
DR KEGG; dme:Dmel_CG17669; -.
DR UCSC; CG17669-RA; d. melanogaster.
DR FlyBase; FBgn0034352; CG17669.
DR VEuPathDB; VectorBase:FBgn0034352; -.
DR eggNOG; ENOG502QT97; Eukaryota.
DR GeneTree; ENSGT00390000002069; -.
DR HOGENOM; CLU_024420_2_1_1; -.
DR InParanoid; A1ZB91; -.
DR OMA; PEYEQCK; -.
DR OrthoDB; 681465at2759; -.
DR PhylomeDB; A1ZB91; -.
DR BioGRID-ORCS; 37125; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 37125; -.
DR PRO; PR:A1ZB91; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0034352; Expressed in testis and 18 other tissues.
DR Genevisible; A1ZB91; DM.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR GO; GO:0070286; P:axonemal dynein complex assembly; IMP:FlyBase.
DR GO; GO:0044458; P:motile cilium assembly; IBA:GO_Central.
DR GO; GO:1905515; P:non-motile cilium assembly; IMP:FlyBase.
DR GO; GO:0120316; P:sperm flagellum assembly; IMP:FlyBase.
DR InterPro; IPR039304; DNAAF3.
DR InterPro; IPR028235; DNAAF3_C.
DR InterPro; IPR027974; DUF4470.
DR PANTHER; PTHR22118; PTHR22118; 1.
DR Pfam; PF14737; DUF4470; 1.
DR Pfam; PF14740; DUF4471; 1.
PE 2: Evidence at transcript level;
KW Cilium biogenesis/degradation; Cytoplasm; Reference proteome.
FT CHAIN 1..540
FT /note="Dynein axonemal assembly factor 3 homolog"
FT /id="PRO_0000297584"
FT REGION 480..499
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 316
FT /note="H -> Y (in Ref. 3; AAV37030)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 540 AA; 62438 MW; 74C6641AB39B8337 CRC64;
MLWGISSALD LYEEYLRAFK IKDDPLPEDE HAREEAEEAA GDNTLNTLNI LICGGADPRH
VIKTLAKRYT HRIRPKLNIY LLDGCAEIEA RNMLLLGVAL EDPESFNLVS KVHLFMDLYG
NAVIRPSSHH YMAAKGRTLL KMVTNEEELQ RLAPMLNIEG LKYKERDGFE MAFTFWQPQP
WNVFEVTAYW EQRSRALLGT RYDHRNGAFD WDLSMTLKER GGQQICSQEY RYWRETGVAF
VFPEYEHCKP NKTLAVGLVR NGRNFIHRGY VGDIQTGPFC GFGLRTVEER MHHSVHGDND
YRATDITERN LMEFFHELLT QTAYEHDTTR SRRYGSVQLL MTPLLNHQEE DAAGQAAYDK
PWIHVPGVTV HFVSPMEMEQ LKKGAAHWNN MFDIVFMAYN YYSFLSKDFF QAMRAQSLFI
LETKLMTVER KDRVQEYESK AKELMKDAGL KAAINYQAIN GKNMWLKYKK TDKDEQEDEA
VTEAMPESTF KYDTDTDYGE PAEEYTGLVI EEIPSSNQTV AAIKKEVEAE GPLQPKTNFP
