ID   DAAF3_MACFA             Reviewed;         540 AA.
AC   Q95K25;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Dynein axonemal assembly factor 3;
GN   Name=DNAAF3; ORFNames=QtsA-10947;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA   Terao K., Sugano S., Hashimoto K.;
RT   "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT   the human genome sequence.";
RL   BMC Genomics 3:36-36(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for the assembly of axonemal inner and outer dynein
CC       arms. Involved in preassembly of dyneins into complexes before their
CC       transport into cilia (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:Q32NQ7}.
CC   -!- SIMILARITY: Belongs to the DNAAF3 family. {ECO:0000305}.
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DR   EMBL; AB070002; BAB62947.1; -; mRNA.
DR   EMBL; AB178986; BAE02037.1; -; mRNA.
DR   AlphaFoldDB; Q95K25; -.
DR   STRING; 9541.XP_005595942.1; -.
DR   eggNOG; ENOG502QT97; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR039304; DNAAF3.
DR   InterPro; IPR028235; DNAAF3_C.
DR   InterPro; IPR027974; DUF4470.
DR   PANTHER; PTHR22118; PTHR22118; 1.
DR   Pfam; PF14737; DUF4470; 1.
DR   Pfam; PF14740; DUF4471; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Cytoplasm; Reference proteome.
FT   CHAIN           1..540
FT                   /note="Dynein axonemal assembly factor 3"
FT                   /id="PRO_0000297581"
FT   REGION          328..355
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          485..522
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        341..355
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   540 AA;  59345 MW;  A3ADF80610954982 CRC64;
     MTTPAGSGRG FGSVSWWGLS PALDLQAESP PVDPDSQADT VHSTPELDVL LLGSVDGRHL
     LRTLSRAKLW PRRRFNFFAL ENNLEAVARH MLIFSLALED PEKMGLQERS ETFLEVWGNA
     LLRPPVAAFV RAQADLLAHL VPEPDRLEEQ LPWLSLRALK FRERDALEAV FRFWAGGEKG
     PEAFPMSRLW DSRLRHYLGS RYDARHGVSD WDLRMKLHDR GAQVIHTQEF RRWRDTGVAF
     ELRDSSAYHV PNRTLASGRL LSYRGERVAA RGYWGDIATG PFVAFGIEAD DESLLRTSNG
     QPVKTAGEIT QHNVTELLRE VAAWGRARAS RGHPEEQQRS EASPEPGTPA STPESFTVHF
     LPLNSAETLH HKSCYNGRFQ LLYVACGVVH LLSPELGACV APGGNLIVEL ARYLVDMRQE
     QLQGFNTQVG ERAQAAGFAP QTGARPSETF ARFCKSQDSA LGSTDPAVEP GTPSLDVLAQ
     PLEASSPAPE GLTQPLQGGT PHWEPCQLPS ESPGSLSEVL AQPQGALALS NCESHSNTGV