ID   DAAF3_MOUSE             Reviewed;         586 AA.
AC   Q3UYV8; B2RX55;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2005, sequence version 1.
DT   03-AUG-2022, entry version 86.
DE   RecName: Full=Dynein axonemal assembly factor 3;
GN   Name=Dnaaf3;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- FUNCTION: Required for the assembly of axonemal inner and outer dynein
CC       arms. Involved in preassembly of dyneins into complexes before their
CC       transport into cilia (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:Q32NQ7}.
CC   -!- SIMILARITY: Belongs to the DNAAF3 family. {ECO:0000305}.
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DR   EMBL; AK134335; BAE22103.1; -; mRNA.
DR   EMBL; BC150983; AAI50984.1; -; mRNA.
DR   CCDS; CCDS20737.1; -.
DR   RefSeq; NP_001028720.1; NM_001033548.2.
DR   AlphaFoldDB; Q3UYV8; -.
DR   BioGRID; 242677; 1.
DR   STRING; 10090.ENSMUSP00000092498; -.
DR   PhosphoSitePlus; Q3UYV8; -.
DR   MaxQB; Q3UYV8; -.
DR   PaxDb; Q3UYV8; -.
DR   PRIDE; Q3UYV8; -.
DR   ProteomicsDB; 279261; -.
DR   Ensembl; ENSMUST00000094897; ENSMUSP00000092498; ENSMUSG00000055809.
DR   GeneID; 436022; -.
DR   KEGG; mmu:436022; -.
DR   UCSC; uc009exw.1; mouse.
DR   CTD; 352909; -.
DR   MGI; MGI:3588207; Dnaaf3.
DR   VEuPathDB; HostDB:ENSMUSG00000055809; -.
DR   eggNOG; ENOG502QT97; Eukaryota.
DR   GeneTree; ENSGT00390000002069; -.
DR   HOGENOM; CLU_024420_2_1_1; -.
DR   InParanoid; Q3UYV8; -.
DR   OMA; MREGIYQ; -.
DR   OrthoDB; 681465at2759; -.
DR   PhylomeDB; Q3UYV8; -.
DR   TreeFam; TF323981; -.
DR   BioGRID-ORCS; 436022; 0 hits in 75 CRISPR screens.
DR   ChiTaRS; Dnaaf3; mouse.
DR   PRO; PR:Q3UYV8; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q3UYV8; protein.
DR   Bgee; ENSMUSG00000055809; Expressed in spermatid and 46 other tissues.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0007368; P:determination of left/right symmetry; IMP:MGI.
DR   GO; GO:0007507; P:heart development; IMP:MGI.
DR   GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR039304; DNAAF3.
DR   InterPro; IPR028235; DNAAF3_C.
DR   InterPro; IPR027974; DUF4470.
DR   PANTHER; PTHR22118; PTHR22118; 1.
DR   Pfam; PF14737; DUF4470; 1.
DR   Pfam; PF14740; DUF4471; 1.
PE   1: Evidence at protein level;
KW   Cilium biogenesis/degradation; Cytoplasm; Reference proteome.
FT   CHAIN           1..586
FT                   /note="Dynein axonemal assembly factor 3"
FT                   /id="PRO_0000297582"
FT   REGION          455..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        479..493
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   586 AA;  64613 MW;  53D69F0FCCC7D45A CRC64;
     MTTPAGSGTG YGSVSWWGLS PALDLQAESP PVDPDSQSKT ERKVPELDAL LLGSVDGRHM
     LRTLARAALW PLRSFNFYVL ENNLEAVARH MLIFSLALEE PEKMGLQERS ETFLELWGNA
     LLRPSVAAFL RAQASHLANL VLEPDRLEEQ LPWLSLRLLK FRERDALEAV FRFWSGGEKG
     PEVFPMSRLW DSRLRHYLGS RYDARRGVAD WDLRMKLHDR GAQVIHIQEF RRWRDTGVAF
     ELRDLSAYHV PNRTLASGRL LSHRGERVAA RGYWGDIATG PFMAFGIEAD DQSLLRTRNG
     QPVKTASEIT QHNVTELFRE VAAWRGPRAI QGNVEETESP EPDVPAQEPF TIHFLPLDSS
     QTLHHKTCYQ GRFQLLYVSC GMVHLLSPEL GACVAPGGNL VVELARYLVD LRPKELKAFS
     DRVVEIARVA GFAPHTATKP SETFARFYKL GDSTPGGGDS AVESGPAPSK VESTRAPLPE
     SISPPQANQA PSLEAMSPPL ADLAPPLETM CPPQANQAPP LEALSPSKAD QIPPLEAMSP
     PQAKLVLPVE AISLPQADLA SPPEVISPLQ EAMATSWVNA PPKHVT