ID   DAAF3_RAT               Reviewed;         583 AA.
AC   D3ZCM9;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   20-APR-2010, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Dynein axonemal assembly factor 3;
GN   Name=Dnaaf3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15057822; DOI=10.1038/nature02426;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
CC   -!- FUNCTION: Required for the assembly of axonemal inner and outer dynein
CC       arms. Involved in preassembly of dyneins into complexes before their
CC       transport into cilia (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:Q32NQ7}.
CC   -!- SIMILARITY: Belongs to the DNAAF3 family. {ECO:0000305}.
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DR   RefSeq; NP_001258044.1; NM_001271115.1.
DR   AlphaFoldDB; D3ZCM9; -.
DR   BioGRID; 1198888; 1.
DR   STRING; 10116.ENSRNOP00000055687; -.
DR   PaxDb; D3ZCM9; -.
DR   GeneID; 100359753; -.
DR   KEGG; rno:100359753; -.
DR   UCSC; RGD:2323487; rat.
DR   CTD; 352909; -.
DR   RGD; 2323487; Dnaaf3.
DR   VEuPathDB; HostDB:ENSRNOG00000038600; -.
DR   eggNOG; ENOG502QT97; Eukaryota.
DR   InParanoid; D3ZCM9; -.
DR   OMA; MREGIYQ; -.
DR   OrthoDB; 681465at2759; -.
DR   PhylomeDB; D3ZCM9; -.
DR   TreeFam; TF323981; -.
DR   PRO; PR:D3ZCM9; -.
DR   Proteomes; UP000002494; Chromosome 1.
DR   Bgee; ENSRNOG00000038600; Expressed in testis and 8 other tissues.
DR   ExpressionAtlas; D3ZCM9; baseline and differential.
DR   Genevisible; D3ZCM9; RN.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0007368; P:determination of left/right symmetry; ISO:RGD.
DR   GO; GO:0007507; P:heart development; ISO:RGD.
DR   GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR039304; DNAAF3.
DR   InterPro; IPR028235; DNAAF3_C.
DR   InterPro; IPR027974; DUF4470.
DR   PANTHER; PTHR22118; PTHR22118; 1.
DR   Pfam; PF14737; DUF4470; 1.
DR   Pfam; PF14740; DUF4471; 1.
PE   3: Inferred from homology;
KW   Cilium biogenesis/degradation; Cytoplasm; Reference proteome.
FT   CHAIN           1..583
FT                   /note="Dynein axonemal assembly factor 3"
FT                   /id="PRO_0000416894"
FT   REGION          455..534
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   583 AA;  64373 MW;  1CE98A69C0E84787 CRC64;
     MTTPAGSGNG FGTVSWWGLS PALDLQAESP PVDPDSQSKT EHKIPELDAL LLGSVDGRHM
     LRTLARAMLW PLRRFNFYVL ENNLEAVARH MLIFSLALEE PEKMGLQERS ETFLELWGNA
     LLRPSVAAFL RAQASHLSNL VPEPDRLEEL LPWLSLRPLK FRERDALEAV FRFWSGGEKG
     PEVFPMSRLW DSRLRHYLGS RYDARRGVAD WDLRMKLHDR GAQVIHFHEF RRWRDTGVAF
     ELRDLSAYHV PNRTMASGRL LSHRGERVAA RGYWGDIATG PFVAFGIEAD DKSLLRTSNG
     QPVKTASEIT QHNVTELFRD VAAWRGPRAI KGNVEETKSP EPDAPAQEPF TIHFLPLDSS
     QTLHHKTCYR GRFQLLYVSC GMIHLLSPEL GACVAPGGNL VVELARYLVD LRPKELKAFS
     DRVVEIAQAA GFAPHTGTKP SETFARFYKL GDSTRGGGDS AVESGPVPSK VLAPTPESIN
     PPQADQAPSL EVMSPPKVDQ TPPLEAMSPP EADQAPPLEA MSPPRADQIP PLEAMSPLQA
     EVVLPLEAIS PPQADLAPPP EVISPVQEAL AMSSAIAPLK HVT