ID   DAAF3_XENLA             Reviewed;         485 AA.
AC   Q32NQ7;
DT   21-AUG-2007, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 37.
DE   RecName: Full=Dynein axonemal assembly factor 3;
GN   Name=dnaaf3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=30561330; DOI=10.7554/elife.38497;
RA   Huizar R.L., Lee C., Boulgakov A.A., Horani A., Tu F., Marcotte E.M.,
RA   Brody S.L., Wallingford J.B.;
RT   "A liquid-like organelle at the root of motile ciliopathy.";
RL   Elife 7:0-0(2018).
CC   -!- FUNCTION: Required for the assembly of axonemal inner and outer dynein
CC       arms. Involved in preassembly of dyneins into complexes before their
CC       transport into cilia (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Dynein axonemal particle
CC       {ECO:0000269|PubMed:30561330}.
CC   -!- SIMILARITY: Belongs to the DNAAF3 family. {ECO:0000305}.
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DR   EMBL; BC108525; AAI08526.1; -; mRNA.
DR   RefSeq; NP_001089839.1; NM_001096370.1.
DR   AlphaFoldDB; Q32NQ7; -.
DR   DNASU; 734905; -.
DR   GeneID; 734905; -.
DR   KEGG; xla:734905; -.
DR   CTD; 734905; -.
DR   Xenbase; XB-GENE-6254736; dnaaf3.L.
DR   OrthoDB; 681465at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 734905; Expressed in testis and 11 other tissues.
DR   GO; GO:0120293; C:dynein axonemal particle; IDA:UniProtKB.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR039304; DNAAF3.
DR   InterPro; IPR028235; DNAAF3_C.
DR   InterPro; IPR027974; DUF4470.
DR   PANTHER; PTHR22118; PTHR22118; 1.
DR   Pfam; PF14737; DUF4470; 1.
DR   Pfam; PF14740; DUF4471; 1.
PE   2: Evidence at transcript level;
KW   Cilium biogenesis/degradation; Cytoplasm; Reference proteome.
FT   CHAIN           1..485
FT                   /note="Dynein axonemal assembly factor 3"
FT                   /id="PRO_0000297583"
SQ   SEQUENCE   485 AA;  55051 MW;  662E81CF3F7CEB6E CRC64;
     MAAAAGRRMG PSWWGFSPAL DLQVHCLQGT IQHLTSSDGL PELNILLVGG GDGRHLLKTI
     CQASRWPHRK LKFFIIESDL ELLARHMLFL SLALEHPEQM GLQEKSELFL ELFGNSLIRS
     KTANYLQEKS ELFIQCVTDP DYQQCVMPFL NLSSIKFKER DELEDIFKFW RIADPKLFPI
     DKYWDGKNRR HLGTRYDSRK GAYDWDLSMK LHDRGAGVIN SREYNYWREK GVAFMNREGV
     YDVPNKTLAS QMVVPQSSGK VLTRGYWGDI TTSPYVAFGI ETEEKSLLET ANGVHVKSAQ
     EIALHNIISL FHELATGKVY SVPASGQAEA ELVKPVGDYK TNGDQTAAET IEEKAEAEDT
     KQSKYKGFIT LNNVEIHFLP LSWVNELHCK GRFTNFFNLL YFSSSMVHLL KPEYKVIAAS
     KATLVLELTK FMVDLQADKV QSYVSIVTKL AQGAGFTSDE PIDWKTHYIA RFERGDDSVE
     LQTAQ