ID   DAAF3_XENTR             Reviewed;         449 AA.
AC   F6S9E6;
DT   18-APR-2012, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 2.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Dynein axonemal assembly factor 3;
GN   Name=dnaaf3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=20431018; DOI=10.1126/science.1183670;
RA   Hellsten U., Harland R.M., Gilchrist M.J., Hendrix D., Jurka J.,
RA   Kapitonov V., Ovcharenko I., Putnam N.H., Shu S., Taher L., Blitz I.L.,
RA   Blumberg B., Dichmann D.S., Dubchak I., Amaya E., Detter J.C., Fletcher R.,
RA   Gerhard D.S., Goodstein D., Graves T., Grigoriev I.V., Grimwood J.,
RA   Kawashima T., Lindquist E., Lucas S.M., Mead P.E., Mitros T., Ogino H.,
RA   Ohta Y., Poliakov A.V., Pollet N., Robert J., Salamov A., Sater A.K.,
RA   Schmutz J., Terry A., Vize P.D., Warren W.C., Wells D., Wills A.,
RA   Wilson R.K., Zimmerman L.B., Zorn A.M., Grainger R., Grammer T.,
RA   Khokha M.K., Richardson P.M., Rokhsar D.S.;
RT   "The genome of the Western clawed frog Xenopus tropicalis.";
RL   Science 328:633-636(2010).
CC   -!- FUNCTION: Required for the assembly of axonemal inner and outer dynein
CC       arms. Involved in preassembly of dyneins into complexes before their
CC       transport into cilia (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:Q32NQ7}.
CC   -!- SIMILARITY: Belongs to the DNAAF3 family. {ECO:0000305}.
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DR   EMBL; AAMC01079094; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; F6S9E6; -.
DR   PaxDb; F6S9E6; -.
DR   PRIDE; F6S9E6; -.
DR   eggNOG; ENOG502QT97; Eukaryota.
DR   HOGENOM; CLU_024420_2_1_1; -.
DR   InParanoid; F6S9E6; -.
DR   OMA; MREGIYQ; -.
DR   Proteomes; UP000008143; Genome assembly.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0070286; P:axonemal dynein complex assembly; ISS:UniProtKB.
DR   GO; GO:0044458; P:motile cilium assembly; ISS:UniProtKB.
DR   InterPro; IPR039304; DNAAF3.
DR   InterPro; IPR028235; DNAAF3_C.
DR   InterPro; IPR027974; DUF4470.
DR   PANTHER; PTHR22118; PTHR22118; 1.
DR   Pfam; PF14737; DUF4470; 1.
DR   Pfam; PF14740; DUF4471; 1.
PE   3: Inferred from homology;
KW   Cilium biogenesis/degradation; Cytoplasm; Reference proteome.
FT   CHAIN           1..449
FT                   /note="Dynein axonemal assembly factor 3"
FT                   /id="PRO_0000416896"
SQ   SEQUENCE   449 AA;  51684 MW;  F2BD67B74144A8C5 CRC64;
     MAAVVRRMGP VWWGLTPALD LQMHLHPPPP PEIYCSCSDD LPELNILLVG GGDGRHILKT
     ICQASRWPHR KLKFFIIESD LELLARHMLF LSLALEHPEQ MGLQEKSELF LELFGNSLIR
     NKTASYLQEK SELFIRYVTD PDYQQSNVPL LNLSSIKFKE RDKLEDIFKF WRNADPKLFP
     IDKYWDEKNR QNLGRRYDSR KGAYDWDLSM KLHDRGAGVI NSREYNYWRE KGVAFMNREG
     VYDIPNKTLA SQMVVPQSSG KVLARGYWGD ITASPYIAFG IETEEESLLQ TANGVHVKSA
     QDIAQHNMIS LFHELAYGKI YSVPASGQAE SELAKTDSDY KTNEEQTVGL ITLNNVEIHF
     LPRFNNFFNL LYFSCSMVHF LKPEYKFIAA SKATLVLELT KFMVDLQTEK LQDYVTIVAK
     LAQEAGFTPT ETIDWKTDYI AKFERAHDS