DAAF4_RAT
ID DAAF4_RAT Reviewed; 420 AA.
AC Q5VJS5;
DT 11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Dynein axonemal assembly factor 4 {ECO:0000312|RGD:1549760};
DE AltName: Full=Dyslexia susceptibility 1 candidate gene 1 protein homolog {ECO:0000250|UniProtKB:Q8WXU2};
GN Name=Dnaaf4 {ECO:0000312|RGD:1549760}; Synonyms=Dyx1c1, Ekn1;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RA Chen Y., Dong W., Peng J., Huang C.;
RT "Molecular structure and evolution of EKN1 genes in a new combination of
RT co-chaperone p23 with tetratricopeptide repeat domain.";
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION, AND SUBCELLULAR LOCATION.
RX PubMed=16989952; DOI=10.1016/j.neuroscience.2006.08.022;
RA Wang Y., Paramasivam M., Thomas A., Bai J., Kaminen-Ahola N., Kere J.,
RA Voskuil J., Rosen G.D., Galaburda A.M., Loturco J.J.;
RT "DYX1C1 functions in neuronal migration in developing neocortex.";
RL Neuroscience 143:515-522(2006).
RN [4]
RP INTERACTION WITH ESR1 AND ESR2, AND SUBCELLULAR LOCATION.
RX PubMed=19423554; DOI=10.1093/hmg/ddp215;
RA Massinen S., Tammimies K., Tapia-Paez I., Matsson H., Hokkanen M.E.,
RA Soederberg O., Landegren U., Castren E., Gustafsson J.A., Treuter E.,
RA Kere J.;
RT "Functional interaction of DYX1C1 with estrogen receptors suggests
RT involvement of hormonal pathways in dyslexia.";
RL Hum. Mol. Genet. 18:2802-2812(2009).
CC -!- FUNCTION: Involved in neuronal migration during development of the
CC cerebral neocortex. May regulate the stability and proteasomal
CC degradation of the estrogen receptors that play an important role in
CC neuronal differentiation, survival and plasticity. Axonemal dynein
CC assembly factor required for ciliary motility (By similarity).
CC {ECO:0000250|UniProtKB:Q8WXU2, ECO:0000269|PubMed:16989952}.
CC -!- SUBUNIT: Interacts with ZMYND10 (By similarity). Interacts with STUB1
CC (By similarity). Interacts with ESR1 and ESR2. Interacts with DNAAF2
CC (By similarity). Interacts with CCT3, CCT4, CCT5 and CCT8 (By
CC similarity). Interacts with DNAAF6/PIH1D3 (By similarity).
CC {ECO:0000250|UniProtKB:Q8R368, ECO:0000250|UniProtKB:Q8WXU2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WXU2}. Cytoplasm
CC {ECO:0000269|PubMed:16989952}. Cell projection, neuron projection
CC {ECO:0000269|PubMed:19423554}. Dynein axonemal particle
CC {ECO:0000250|UniProtKB:Q6AZN0}.
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DR EMBL; AY428506; AAR89524.1; -; mRNA.
DR EMBL; BC085838; AAH85838.1; -; mRNA.
DR RefSeq; NP_001007011.1; NM_001007010.1.
DR AlphaFoldDB; Q5VJS5; -.
DR SMR; Q5VJS5; -.
DR BioGRID; 263962; 2.
DR STRING; 10116.ENSRNOP00000029714; -.
DR PhosphoSitePlus; Q5VJS5; -.
DR PaxDb; Q5VJS5; -.
DR PRIDE; Q5VJS5; -.
DR Ensembl; ENSRNOT00000085959; ENSRNOP00000072890; ENSRNOG00000056654.
DR GeneID; 363096; -.
DR KEGG; rno:363096; -.
DR UCSC; RGD:1549760; rat.
DR CTD; 161582; -.
DR RGD; 1549760; Dnaaf4.
DR eggNOG; KOG1124; Eukaryota.
DR GeneTree; ENSGT00390000004930; -.
DR HOGENOM; CLU_029084_0_0_1; -.
DR InParanoid; Q5VJS5; -.
DR OMA; PPYLFEV; -.
DR OrthoDB; 1485667at2759; -.
DR PhylomeDB; Q5VJS5; -.
DR TreeFam; TF328983; -.
DR PRO; PR:Q5VJS5; -.
DR Proteomes; UP000002494; Chromosome 8.
DR Bgee; ENSRNOG00000056654; Expressed in testis and 11 other tissues.
DR GO; GO:0005813; C:centrosome; IDA:MGI.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR GO; GO:0005576; C:extracellular region; IEA:GOC.
DR GO; GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
DR GO; GO:0097730; C:non-motile cilium; IDA:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0030331; F:nuclear estrogen receptor binding; IDA:UniProtKB.
DR GO; GO:0003341; P:cilium movement; ISS:UniProtKB.
DR GO; GO:0007368; P:determination of left/right symmetry; ISS:UniProtKB.
DR GO; GO:0003351; P:epithelial cilium movement involved in extracellular fluid movement; ISO:RGD.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0007507; P:heart development; ISO:RGD.
DR GO; GO:0036159; P:inner dynein arm assembly; ISS:UniProtKB.
DR GO; GO:0007611; P:learning or memory; ISO:RGD.
DR GO; GO:0001764; P:neuron migration; IMP:UniProtKB.
DR GO; GO:0036158; P:outer dynein arm assembly; ISS:UniProtKB.
DR GO; GO:0033146; P:regulation of intracellular estrogen receptor signaling pathway; ISS:UniProtKB.
DR GO; GO:0061136; P:regulation of proteasomal protein catabolic process; ISS:UniProtKB.
DR CDD; cd06469; p23_DYX1C1_like; 1.
DR Gene3D; 1.25.40.10; -; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR037894; CS_DYX1C1.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR Pfam; PF04969; CS; 1.
DR SMART; SM00028; TPR; 3.
DR SUPFAM; SSF48452; SSF48452; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS51203; CS; 1.
DR PROSITE; PS50005; TPR; 3.
DR PROSITE; PS50293; TPR_REGION; 1.
PE 1: Evidence at protein level;
KW Cell projection; Cytoplasm; Neurogenesis; Nucleus; Reference proteome;
KW Repeat; TPR repeat.
FT CHAIN 1..420
FT /note="Dynein axonemal assembly factor 4"
FT /id="PRO_0000403480"
FT DOMAIN 3..87
FT /note="CS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT REPEAT 288..321
FT /note="TPR 1"
FT REPEAT 323..355
FT /note="TPR 2"
FT REPEAT 364..397
FT /note="TPR 3"
FT REGION 7..103
FT /note="Mediates interaction with ESR1 and STUB1"
FT /evidence="ECO:0000250"
FT REGION 165..212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..187
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 420 AA; 48119 MW; 0DA24EBCB50EA32A CRC64;
MPVRVSEFSW QQTPAALFLS LPLRGVCVRD ADVFCGESYL KVNFPPFLFE VFLYAPIDDG
KSKAKIGNDT ILFTLYKKEP VLWESLSMPG VDKEMMQRIR EKSILQAQEK AKEATEAKAA
AKREDQRYAL GEMMKIEEEE RKKIEDMKEN ERKKATRELE AWKECQKKAD GQKRVQRKEK
PLQGKQAEER GALKPQSLPR KAPPTRLPTR GRNWENIFSE KLKEDRVPAP RSAGSIQISF
TPRVFPTALR ESQVAEEEEW LHKQAEARRA MSTDLPEFSD LKEEEKNPDW LKDKGNKLFA
TENYLAAIDA YNLAIRLNRK IPVLYLNRAA CHLKLKNLHK AIEDSSKALE LLTPPVADNA
NARMKAHVRR GTAFCQLELY VEGLQDYEAA LKIDPANTVV QNDAEKIRNI IQGTTLKSHD
