ID   DAAF4_XENLA             Reviewed;         421 AA.
AC   Q6AZN0;
DT   07-APR-2021, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2004, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Dynein axonemal assembly factor 4 {ECO:0000305};
GN   Name=dnaaf4 {ECO:0000312|Xenbase:XB-GENE-959584};
GN   Synonyms=dyx1c1 {ECO:0000312|Xenbase:XB-GENE-959584};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000312|EMBL:AAH77575.1};
RN   [1] {ECO:0000312|EMBL:AAH77575.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   SUBCELLULAR LOCATION.
RX   PubMed=30561330; DOI=10.7554/elife.38497;
RA   Huizar R.L., Lee C., Boulgakov A.A., Horani A., Tu F., Marcotte E.M.,
RA   Brody S.L., Wallingford J.B.;
RT   "A liquid-like organelle at the root of motile ciliopathy.";
RL   Elife 7:0-0(2018).
CC   -!- FUNCTION: Axonemal dynein assembly factor required for ciliary
CC       motility. {ECO:0000250|UniProtKB:Q8WXU2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8WXU2}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q5VJS5}. Cell projection, neuron projection
CC       {ECO:0000250|UniProtKB:Q5VJS5}. Dynein axonemal particle
CC       {ECO:0000269|PubMed:30561330}.
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DR   EMBL; BC077575; AAH77575.1; -; mRNA.
DR   RefSeq; NP_001086864.1; NM_001093395.1.
DR   AlphaFoldDB; Q6AZN0; -.
DR   SMR; Q6AZN0; -.
DR   DNASU; 446699; -.
DR   GeneID; 446699; -.
DR   KEGG; xla:446699; -.
DR   CTD; 446699; -.
DR   Xenbase; XB-GENE-959584; dnaaf4.L.
DR   OrthoDB; 1485667at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 446699; Expressed in gastrula and 16 other tissues.
DR   GO; GO:0120293; C:dynein axonemal particle; IDA:UniProtKB.
DR   GO; GO:0043005; C:neuron projection; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003341; P:cilium movement; IEA:InterPro.
DR   GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR   CDD; cd06469; p23_DYX1C1_like; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR007052; CS_dom.
DR   InterPro; IPR037894; CS_DYX1C1.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   Pfam; PF04969; CS; 1.
DR   SMART; SM00028; TPR; 3.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS51203; CS; 1.
DR   PROSITE; PS50005; TPR; 2.
DR   PROSITE; PS50293; TPR_REGION; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Coiled coil; Cytoplasm; Neurogenesis; Nucleus;
KW   Reference proteome; Repeat; TPR repeat.
FT   CHAIN           1..421
FT                   /note="Dynein axonemal assembly factor 4"
FT                   /id="PRO_0000452449"
FT   DOMAIN          3..87
FT                   /note="CS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT   REPEAT          280..313
FT                   /note="TPR 1"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00339"
FT   REPEAT          315..347
FT                   /note="TPR 4"
FT                   /evidence="ECO:0000255"
FT   REPEAT          356..389
FT                   /note="TPR 2"
FT                   /evidence="ECO:0000255, ECO:0000255|PROSITE-
FT                   ProRule:PRU00339"
FT   REGION          103..122
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   421 AA;  48216 MW;  1448B63D7B4F48E4 CRC64;
     MPIIANDYTW EQSENDVYIS VPLKGTKASA SNVLCSESYL KVNFPPFLFE AFLFAPIDDS
     TSSAKIGNGV ILFNLHKKEP AVWDALTLAH MEKEEMQKIR ENAVAKEQEK AQEETKAKAE
     RKRENEKYSL EVTMKIDEVE RKRIEDVKEE ERKKATEELE KWKEKQRIQK LNEMIQKKQI
     RQENERNKAL HTGSLKHCST ATTVQNDRTI NVKQKEKILP PTRSTGCIQI QFTPRVFPTA
     LRESRVAEEE EWLHKQAEAR RATNTVDLGL EDLTEEEKNP EWLKDKGNKL FAAGDYLAAV
     NALNLAIRLN NKIPGLYLNR SACHLKLRNL HKTIEDSSKA LELLTPPVPG NASARIKAHV
     RRGTAFCELE LYVEGLQDYE AALKIDPTNQ NMKSDAEKIR RVIQSSLPDI ERGIMLDIKD
     L