ID   DAAF8_RAT               Reviewed;         481 AA.
AC   Q5XIK6;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Dynein axonemal assembly factor 8 {ECO:0000305};
DE   AltName: Full=Dynein axonemal-associated protein 1 {ECO:0000305};
DE   AltName: Full=Uncharacterized protein C16orf71 homolog;
GN   Name=Dnaaf8; Synonyms=Daap1 {ECO:0000250|UniProtKB:Q8IYS4};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-83; SER-145; SER-147 AND
RP   SER-328, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- FUNCTION: In cyliated cells, dynein axonemal particle-specific protein
CC       required for deployment of ODA to the axoneme. Interacts with outer
CC       dynein arm (ODA) subunits. {ECO:0000250|UniProtKB:A0A1L8EYB2}.
CC   -!- SUBCELLULAR LOCATION: Dynein axonemal particle
CC       {ECO:0000250|UniProtKB:Q8IYS4}.
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DR   EMBL; BC083674; AAH83674.1; -; mRNA.
DR   RefSeq; NP_001014137.1; NM_001014115.1.
DR   RefSeq; XP_006245869.1; XM_006245807.3.
DR   RefSeq; XP_006245871.1; XM_006245809.3.
DR   RefSeq; XP_006245872.1; XM_006245810.3.
DR   RefSeq; XP_017452853.1; XM_017597364.1.
DR   AlphaFoldDB; Q5XIK6; -.
DR   STRING; 10116.ENSRNOP00000037410; -.
DR   iPTMnet; Q5XIK6; -.
DR   PhosphoSitePlus; Q5XIK6; -.
DR   PaxDb; Q5XIK6; -.
DR   PRIDE; Q5XIK6; -.
DR   Ensembl; ENSRNOT00000036954; ENSRNOP00000037410; ENSRNOG00000028075.
DR   GeneID; 360479; -.
DR   KEGG; rno:360479; -.
DR   UCSC; RGD:1359596; rat.
DR   CTD; 146562; -.
DR   RGD; 1359596; LOC360479.
DR   eggNOG; ENOG502SAQ4; Eukaryota.
DR   GeneTree; ENSGT00390000015381; -.
DR   InParanoid; Q5XIK6; -.
DR   OMA; VWWAADR; -.
DR   OrthoDB; 1111863at2759; -.
DR   PhylomeDB; Q5XIK6; -.
DR   TreeFam; TF336688; -.
DR   PRO; PR:Q5XIK6; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000028075; Expressed in testis and 16 other tissues.
DR   Genevisible; Q5XIK6; RN.
DR   GO; GO:0120293; C:dynein axonemal particle; ISS:UniProtKB.
DR   GO; GO:0070840; F:dynein complex binding; ISS:UniProtKB.
DR   GO; GO:0036158; P:outer dynein arm assembly; ISS:UniProtKB.
DR   InterPro; IPR031531; DNAAF8.
DR   PANTHER; PTHR35977; PTHR35977; 1.
DR   Pfam; PF15773; DUF4701; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Phosphoprotein; Reference proteome.
FT   CHAIN           1..481
FT                   /note="Dynein axonemal assembly factor 8"
FT                   /id="PRO_0000294347"
FT   REGION          70..91
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          131..233
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          306..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          415..454
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..180
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        306..320
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        321..335
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        336..352
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        362..384
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         83
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         145
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         147
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
FT   MOD_RES         328
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   481 AA;  52998 MW;  1F9ED7ED42DB0705 CRC64;
     MTSKDKAVVS LPVSPWDAIL KAAKDQLPSL DSDSSLSDCE EEEPFIFQRN QPVLIPDLTE
     ELAEDPVGVD ESGTWVTAGR SPSPEPLLVP GRLAIEPRSE WMVRSKDLAH QERRGPGWSC
     QSCVKSSPIL LDTKEAPAWP EGRGSQSPPW SSQGEGATFP LEGKLKTEPS DTDFKNSAKR
     RALRRERRKM IEREILQKVT QAAQNPASGD QGQVAELGPR PKATSEQSWE GRPVLSLKQL
     EGWDLDYILQ SLPGQQGSQG DSASRSAWWL ADRCQDQGHS TGPSQDILLE QLALLCATQS
     RVRHPTWKVS ADKLQDTEEQ VARTRSASAE SGFQTERVQK RAESRRLKTE PPTVFLDLRL
     TEPSDPQEHQ SQESSEHSSS DSEEEEVGSA GSIPVASSWE QRYCTGKSQL LQQLRAFRKG
     AVPPQLSAKD GPGGQKDQAQ EDTGGSQTQR KKHIKLWAEK QNALNLGDPL GTRLLPGMGQ
     L