DABA_BACAN
ID DABA_BACAN Reviewed; 874 AA.
AC Q81NL0; Q6HWS3; Q6KQW6;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Probable inorganic carbon transporter subunit DabA {ECO:0000255|HAMAP-Rule:MF_01871, ECO:0000303|PubMed:31406332};
GN Name=dabA {ECO:0000255|HAMAP-Rule:MF_01871, ECO:0000303|PubMed:31406332};
GN OrderedLocusNames=BA_3182, GBAA_3182, BAS2958;
OS Bacillus anthracis.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC Bacillus cereus group.
OX NCBI_TaxID=1392;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames / isolate Porton;
RX PubMed=12721629; DOI=10.1038/nature01586;
RA Read T.D., Peterson S.N., Tourasse N.J., Baillie L.W., Paulsen I.T.,
RA Nelson K.E., Tettelin H., Fouts D.E., Eisen J.A., Gill S.R.,
RA Holtzapple E.K., Okstad O.A., Helgason E., Rilstone J., Wu M.,
RA Kolonay J.F., Beanan M.J., Dodson R.J., Brinkac L.M., Gwinn M.L.,
RA DeBoy R.T., Madpu R., Daugherty S.C., Durkin A.S., Haft D.H., Nelson W.C.,
RA Peterson J.D., Pop M., Khouri H.M., Radune D., Benton J.L., Mahamoud Y.,
RA Jiang L., Hance I.R., Weidman J.F., Berry K.J., Plaut R.D., Wolf A.M.,
RA Watkins K.L., Nierman W.C., Hazen A., Cline R.T., Redmond C., Thwaite J.E.,
RA White O., Salzberg S.L., Thomason B., Friedlander A.M., Koehler T.M.,
RA Hanna P.C., Kolstoe A.-B., Fraser C.M.;
RT "The genome sequence of Bacillus anthracis Ames and comparison to closely
RT related bacteria.";
RL Nature 423:81-86(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Sterne;
RA Brettin T.S., Bruce D., Challacombe J.F., Gilna P., Han C., Hill K.,
RA Hitchcock P., Jackson P., Keim P., Longmire J., Lucas S., Okinaka R.,
RA Richardson P., Rubin E., Tice H.;
RT "Complete genome sequence of Bacillus anthracis Sterne.";
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ames ancestor;
RX PubMed=18952800; DOI=10.1128/jb.01347-08;
RA Ravel J., Jiang L., Stanley S.T., Wilson M.R., Decker R.S., Read T.D.,
RA Worsham P., Keim P.S., Salzberg S.L., Fraser-Liggett C.M., Rasko D.A.;
RT "The complete genome sequence of Bacillus anthracis Ames 'Ancestor'.";
RL J. Bacteriol. 191:445-446(2009).
RN [4]
RP FUNCTION, AND EXPRESSION IN ECOLI.
RC STRAIN=Sterne;
RX PubMed=31406332; DOI=10.1038/s41564-019-0520-8;
RA Desmarais J.J., Flamholz A.I., Blikstad C., Dugan E.J., Laughlin T.G.,
RA Oltrogge L.M., Chen A.W., Wetmore K., Diamond S., Wang J.Y., Savage D.F.;
RT "DABs are inorganic carbon pumps found throughout prokaryotic phyla.";
RL Nat. Microbiol. 4:2204-2215(2019).
CC -!- FUNCTION: Part of an energy-coupled inorganic carbon pump.
CC {ECO:0000255|HAMAP-Rule:MF_01871}.
CC -!- FUNCTION: Expression of both dabA and dabB (DA2) restores growth in
CC ambient air to E.coli deleted of its carbonic anhydrase genes (called
CC CAfree, deletion of 'can' and 'cynT'). {ECO:0000269|PubMed:31406332}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01871};
CC -!- SUBUNIT: Forms a complex with DabB. {ECO:0000255|HAMAP-Rule:MF_01871}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_01871};
CC Peripheral membrane protein {ECO:0000255|HAMAP-Rule:MF_01871}.
CC -!- SIMILARITY: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA
CC family. {ECO:0000255|HAMAP-Rule:MF_01871}.
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DR EMBL; AE016879; AAP26978.1; -; Genomic_DNA.
DR EMBL; AE017334; AAT32298.1; -; Genomic_DNA.
DR EMBL; AE017225; AAT55266.1; -; Genomic_DNA.
DR RefSeq; NP_845492.1; NC_003997.3.
DR RefSeq; WP_000026985.1; NZ_WXXJ01000008.1.
DR RefSeq; YP_029215.1; NC_005945.1.
DR AlphaFoldDB; Q81NL0; -.
DR SMR; Q81NL0; -.
DR STRING; 260799.BAS2958; -.
DR DNASU; 1086884; -.
DR EnsemblBacteria; AAP26978; AAP26978; BA_3182.
DR EnsemblBacteria; AAT32298; AAT32298; GBAA_3182.
DR GeneID; 45022968; -.
DR KEGG; ban:BA_3182; -.
DR KEGG; bar:GBAA_3182; -.
DR KEGG; bat:BAS2958; -.
DR PATRIC; fig|198094.11.peg.3167; -.
DR eggNOG; COG3002; Bacteria.
DR HOGENOM; CLU_009885_0_0_9; -.
DR OMA; DCDLEGR; -.
DR Proteomes; UP000000427; Chromosome.
DR Proteomes; UP000000594; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01871; DabA; 1.
DR InterPro; IPR018752; DabA.
DR PANTHER; PTHR38344; PTHR38344; 1.
DR Pfam; PF10070; MpsB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Metal-binding; Reference proteome; Transport;
KW Zinc.
FT CHAIN 1..874
FT /note="Probable inorganic carbon transporter subunit DabA"
FT /id="PRO_0000387234"
FT BINDING 398
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01871"
FT BINDING 400
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01871"
FT BINDING 580
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01871"
FT BINDING 595
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01871"
SQ SEQUENCE 874 AA; 99265 MW; 3534B9241049326B CRC64;
MSIPSILRKE TLKKKDKNID LQENNINDLV VSASRVIAPL WPISTFAAHH PWMGLEKQSF
EQVANWLKEA RNVDIYPSAS MIHSAKAKGE IEESFLQIAL SRWLDSQSFH MPRETAERFC
QEALKLERLP SSLLSSPELN KLAEEINYVN TGSMKDSSMQ PISSLIENQN GDNLSDILNY
HIIKWCKLYL DDAGASWAMP NREKGFYRAW QHLITFDPAL SKTERKVLKD WPEDALIALT
KALSELGISE SNMQAYLEGH LLSLPGWAGM IRWRSQQSIE EQELLIEYLA VRLSMELAIV
KPYLPLKNQK VEKKVSIVPL IASWIYWGDI SIEKWLQMSA TEQSELLAFA YRFDENTRKK
LWLEAWEQTH AEQLREKIAS KQRATHDKKR VVAQLAFCID VRSEPFRRHL EKLGPFETFG
IAGFFGLPIA TTELGSNDSH PSLPVILKPK HQIKELTDEN ECKSYEQRKM VGSSVRYTFK
TMKQNVLTSM LLPEVSGPLL GLQMVTRSFV PRRVGGFIRN LRKNMLQKPD TTFSLNHVHD
TNCEIPIGFT KEEKVNYVRQ TLKMVGLTEG FAPLVVMCGH SSQSTNNPYA AALECGACGG
AAGGFNARVF ATLCNLPEVR EALSAEGIKI PDDTIFAAAE HKTTVDELEW IYVPELSETA
QEAFDCIEAI MPNVSQHANR ERLMQLPHFK TKIKNPSKEA HRFAEDWSEI RPEWGLARNA
SFIIGQRELT QECDLEGRAF LHNYDWKQDE SGDILANIIA GPGTVAQWIN LQYYASTVAP
HYYGSGNKAT QTVTAGLGVM QGNASDLLPG LPWQSVMQSD RETYHSPLRL LIVIQAPTKY
IERLLNNNFT FREKVQNGWV RLASVDPEGR WKNW