DABA_HYDCU
ID DABA_HYDCU Reviewed; 823 AA.
AC Q31HC3;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 06-DEC-2005, sequence version 1.
DT 03-AUG-2022, entry version 77.
DE RecName: Full=Probable inorganic carbon transporter subunit DabA {ECO:0000255|HAMAP-Rule:MF_01871};
GN Name=dabA {ECO:0000255|HAMAP-Rule:MF_01871}; OrderedLocusNames=Tcr_0854;
OS Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2) (Thiomicrospira
OS crunogena).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Thiotrichales;
OC Piscirickettsiaceae; Hydrogenovibrio.
OX NCBI_TaxID=317025;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 25203 / XCL-2;
RX PubMed=17105352; DOI=10.1371/journal.pbio.0040383;
RA Scott K.M., Sievert S.M., Abril F.N., Ball L.A., Barrett C.J., Blake R.A.,
RA Boller A.J., Chain P.S.G., Clark J.A., Davis C.R., Detter C., Do K.F.,
RA Dobrinski K.P., Faza B.I., Fitzpatrick K.A., Freyermuth S.K., Harmer T.L.,
RA Hauser L.J., Huegler M., Kerfeld C.A., Klotz M.G., Kong W.W., Land M.,
RA Lapidus A., Larimer F.W., Longo D.L., Lucas S., Malfatti S.A., Massey S.E.,
RA Martin D.D., McCuddin Z., Meyer F., Moore J.L., Ocampo L.H. Jr., Paul J.H.,
RA Paulsen I.T., Reep D.K., Ren Q., Ross R.L., Sato P.Y., Thomas P.,
RA Tinkham L.E., Zeruth G.T.;
RT "The genome of deep-sea vent chemolithoautotroph Thiomicrospira crunogena
RT XCL-2.";
RL PLoS Biol. 4:1-17(2006).
RN [2]
RP ACTIVITY REGULATION.
RC STRAIN=DSM 25203 / XCL-2;
RX PubMed=26581415; DOI=10.1007/s00203-015-1172-6;
RG USF MCB4404L 2012;
RA Menning K.J., Menon B.B., Fox G., Scott K.M.;
RT "Dissolved inorganic carbon uptake in Thiomicrospira crunogena XCL-2 is
RT Deltap- and ATP-sensitive and enhances RubisCO-mediated carbon fixation.";
RL Arch. Microbiol. 198:149-159(2016).
RN [3]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RC STRAIN=DSM 25203 / XCL-2;
RX PubMed=28115547; DOI=10.1128/jb.00871-16;
RG USF MCB4404L;
RA Mangiapia M., Brown T.W., Chaput D., Haller E., Harmer T.L., Hashemy Z.,
RA Keeley R., Leonard J., Mancera P., Nicholson D., Stevens S., Wanjugi P.,
RA Zabinski T., Pan C., Scott K.M.;
RT "Proteomic and Mutant Analysis of the CO2 Concentrating Mechanism of
RT Hydrothermal Vent Chemolithoautotroph Thiomicrospira crunogena.";
RL J. Bacteriol. 199:0-0(2017).
CC -!- FUNCTION: Part of an energy-coupled inorganic carbon pump.
CC {ECO:0000255|HAMAP-Rule:MF_01871}.
CC -!- FUNCTION: Probably involved in transport of dissolved inorganic carbon
CC (DIC) with upstream gene dabB (Tcr_0853); has been suggested to be a
CC proton-DIC symporter. {ECO:0000305|PubMed:28115547}.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01871};
CC -!- ACTIVITY REGULATION: Intracellular DIC accumulation is sensitive to
CC CCCP (carbonyl cyanide-m-chlorophenylhydrazone) and DCCD (N,N-
CC dicyclohexylcarbodiimide) and therefore likely driven by either proton
CC potential, ATP, or both. {ECO:0000269|PubMed:26581415}.
CC -!- SUBUNIT: Forms a complex with DabB. {ECO:0000255|HAMAP-Rule:MF_01871}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_01871}; Peripheral membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_01871}.
CC -!- INDUCTION: Induced by growth in low levels of dissolved inorganic
CC carbon (DIC) (at protein level). {ECO:0000269|PubMed:28115547}.
CC -!- DISRUPTION PHENOTYPE: Cells do not grow in low DIC levels, increased
CC carboxysome content. Decreased ability to accumulate and fix DIC under
CC DIC-limiting conditions. {ECO:0000269|PubMed:28115547}.
CC -!- SIMILARITY: Belongs to the inorganic carbon transporter (TC 9.A.2) DabA
CC family. {ECO:0000255|HAMAP-Rule:MF_01871}.
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DR EMBL; CP000109; ABB41450.1; -; Genomic_DNA.
DR RefSeq; WP_011370277.1; NC_007520.2.
DR AlphaFoldDB; Q31HC3; -.
DR STRING; 317025.Tcr_0854; -.
DR TCDB; 9.A.2.1.1; the putative dissolved inorganic carbon concentrating transporter (dic-ct) family.
DR EnsemblBacteria; ABB41450; ABB41450; Tcr_0854.
DR KEGG; tcx:Tcr_0854; -.
DR eggNOG; COG3002; Bacteria.
DR HOGENOM; CLU_009885_1_0_6; -.
DR OMA; DCDLEGR; -.
DR OrthoDB; 179501at2; -.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR HAMAP; MF_01871; DabA; 1.
DR InterPro; IPR018752; DabA.
DR PANTHER; PTHR38344; PTHR38344; 2.
DR Pfam; PF10070; MpsB; 1.
PE 1: Evidence at protein level;
KW Cell inner membrane; Cell membrane; Membrane; Metal-binding; Transport;
KW Zinc.
FT CHAIN 1..823
FT /note="Probable inorganic carbon transporter subunit DabA"
FT /id="PRO_0000387322"
FT BINDING 361
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01871"
FT BINDING 363
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01871"
FT BINDING 527
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01871"
FT BINDING 542
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01871"
SQ SEQUENCE 823 AA; 93448 MW; EB9A8E23E187F01D CRC64;
MMLHNAKASD NNELDQAKPL IPQLSDKQKE ALNDACGRIA PTWPLDELIA VNPWWEMRDQ
HISKVSAKLS ALSQAQCVMP KSYFQEVWME TLQPQHVQQA IDEMEKDYTV DNLERYLLEE
DEHTHWHNVS DFVDSGRDRK YKMAWRDEIT HQISQFCADF FRLKDSQGTF SKTYQGLYHE
WLATTRQDKG IEILMGEDGL TEHFMDLPES SESLLAEALV GLRVPDSQIA DYAHALLLDA
NGWASWVAYL RWQDRLSNAE NDLMMDFLAI RVAWEWVLWQ HQKDSDRSVF NELKVMWHHQ
MSILPDLIAT HEAAQAKSWI WQRAAEIAYQ SELQQQLKHA SRTDQKVETE SPPVLLQAAF
CIDVRSEVIR RALEAQDSRV ETLGFAGFFG LPIEYQPAGT DVSRPQLPGL LKSGIKVTPV
MTKVSKGATK QALNRKARWI EWGNAPPATF SMVEATGLMY AFKLLRNSLF PESHTNPINA
IPATDAFELT QNDSPLTLDQ KVELAAGILH AMGLDHDLAE TVMLVGHGST SCNNPHAAGL
DCGACGGQTG EINVRVLAFL LNDESVRQGL LEKDIKIPAQ TRFVAAMHNT TTDEFTCFGL
NHVDETIQKW LARATEFARQ ERSTRLGLNH LEGQNLHQSI QRRAKDWSQV RPEWGLSNNA
AFIVAPRART RGVDFQGRAF LHDYDWQQDA DNSLLTLIMT APMVVTNWIN LQYYASVCDN
HVYGSGNKVL HNVVDGCIGV FEGNGGDLRI GLPMQSLHNG EKWMHEPLRL SVYIDAPQKT
IAQVVAENDV VRHLIDNEWL YCFSWAPDGR IHRYFNNQWL ESA
