ID   DABB_PSEMU              Reviewed;         249 AA.
AC   A0A386L1Q6;
DT   23-FEB-2022, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2018, sequence version 1.
DT   23-FEB-2022, entry version 5.
DE   RecName: Full=Domoic acid biosynthesis cluster protein B {ECO:0000303|PubMed:30262498};
DE            Short=PmDabB {ECO:0000303|PubMed:30262498};
GN   Name=dabB {ECO:0000303|PubMed:30262498};
OS   Pseudo-nitzschia multiseries (Marine planktonic diatom) (Nitzschia pungens
OS   f. multiseries).
OC   Eukaryota; Sar; Stramenopiles; Ochrophyta; Bacillariophyta;
OC   Bacillariophyceae; Bacillariophycidae; Bacillariales; Bacillariaceae;
OC   Pseudo-nitzschia.
OX   NCBI_TaxID=37319;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND INDUCTION BY PHOSPHATE
RP   LIMITATION AND CO(2).
RC   STRAIN=15091C3;
RX   PubMed=30262498; DOI=10.1126/science.aau0382;
RA   Brunson J.K., McKinnie S.M.K., Chekan J.R., McCrow J.P., Miles Z.D.,
RA   Bertrand E.M., Bielinski V.A., Luhavaya H., Obornik M., Smith G.J.,
RA   Hutchins D.A., Allen A.E., Moore B.S.;
RT   "Biosynthesis of the neurotoxin domoic acid in a bloom-forming diatom.";
RL   Science 361:1356-1358(2018).
CC   -!- FUNCTION: Unknown function: part of the gene cluster that mediates the
CC       biosynthesis of domoic acid (DA) and derivatives, natural products with
CC       neurochemical activity acting as ionotropic glutamate receptor (iGluR)
CC       agonists, thus being neurotoxins causing amnesic shellfish poisoning
CC       (ASP). {ECO:0000305|PubMed:30262498}.
CC   -!- INDUCTION: Up-regulated under phosphate limitation and by increasing
CC       partial pressure of CO(2). {ECO:0000269|PubMed:30262498}.
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DR   EMBL; MH202990; AYD91072.1; -; Genomic_DNA.
DR   GO; GO:0071244; P:cellular response to carbon dioxide; IEP:UniProtKB.
DR   GO; GO:0016036; P:cellular response to phosphate starvation; IEP:UniProtKB.
PE   2: Evidence at transcript level;
FT   CHAIN           1..249
FT                   /note="Domoic acid biosynthesis cluster protein B"
FT                   /id="PRO_0000454276"
SQ   SEQUENCE   249 AA;  28002 MW;  7755CD02948FAF6D CRC64;
     MMAGRKGYQS VMDENCHDKT ESAYTDDRSL NGSSGSSCLK NNVIAFFLGA AVVAATQYVS
     IDSSLTKAVE VTSFTTSDAP AIDIAINPTR PSLDARQDFK IEGWGNQTRN DGWPSFHFEV
     FHFCPHLINF MYENQVHPQS RVDPSNVIYD AQHPGALAED GFAEVLQQTL PKFYDYPVGY
     RLNDRPAEIS AYWTLHMRIA RGSEDSQWHD FASSLPEGIN RIYVKKPLQW NGDHVTLFSS
     QTGYNILVY