DAC1_CAEEL
ID DAC1_CAEEL Reviewed; 420 AA.
AC H2KY91; Q86GT3;
DT 02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT 21-MAR-2012, sequence version 1.
DT 03-AUG-2022, entry version 62.
DE RecName: Full=Dachshund homolog dac-1 {ECO:0000305};
GN Name=dac-1 {ECO:0000312|WormBase:B0412.1a};
GN ORFNames=B0412.1 {ECO:0000312|WormBase:B0412.1a};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=15620651; DOI=10.1016/j.cub.2004.12.030;
RA Colosimo M.E., Brown A., Mukhopadhyay S., Gabel C., Lanjuin A.E.,
RA Samuel A.D., Sengupta P.;
RT "Identification of thermosensory and olfactory neuron-specific genes via
RT expression profiling of single neuron types.";
RL Curr. Biol. 14:2245-2251(2004).
CC -!- FUNCTION: Transcription factor (By similarity). Plays a role in the
CC thermotactic response (PubMed:15620651). {ECO:0000250|UniProtKB:Q9UI36,
CC ECO:0000269|PubMed:15620651}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:15620651}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=a {ECO:0000312|WormBase:B0412.1a};
CC IsoId=H2KY91-1; Sequence=Displayed;
CC Name=b {ECO:0000312|WormBase:B0412.1b};
CC IsoId=H2KY91-2; Sequence=VSP_061105;
CC -!- TISSUE SPECIFICITY: Expressed in AFD, AWC, ASE and ASK neurons
CC (PubMed:15620651). Expressed in the alae (PubMed:15620651).
CC {ECO:0000269|PubMed:15620651}.
CC -!- SIMILARITY: Belongs to the DACH/dachshund family. {ECO:0000305}.
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DR EMBL; BX284603; CCD61864.1; -; Genomic_DNA.
DR EMBL; BX284603; CCD61865.1; -; Genomic_DNA.
DR RefSeq; NP_001021129.1; NM_001025958.3. [H2KY91-1]
DR RefSeq; NP_001021130.1; NM_001025959.2. [H2KY91-2]
DR AlphaFoldDB; H2KY91; -.
DR SMR; H2KY91; -.
DR IntAct; H2KY91; 6.
DR STRING; 6239.B0412.1a; -.
DR PaxDb; H2KY91; -.
DR EnsemblMetazoa; B0412.1a.1; B0412.1a.1; WBGene00000895. [H2KY91-1]
DR EnsemblMetazoa; B0412.1b.1; B0412.1b.1; WBGene00000895. [H2KY91-2]
DR GeneID; 175238; -.
DR KEGG; cel:CELE_B0412.1; -.
DR UCSC; B0412.1a; c. elegans.
DR CTD; 175238; -.
DR WormBase; B0412.1a; CE26848; WBGene00000895; dac-1.
DR WormBase; B0412.1b; CE33550; WBGene00000895; dac-1.
DR eggNOG; KOG3915; Eukaryota.
DR GeneTree; ENSGT00390000001134; -.
DR HOGENOM; CLU_054108_0_0_1; -.
DR InParanoid; H2KY91; -.
DR OMA; KEMICLP; -.
DR OrthoDB; 1242041at2759; -.
DR SignaLink; H2KY91; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00000895; Expressed in larva and 3 other tissues.
DR ExpressionAtlas; H2KY91; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0043052; P:thermotaxis; IMP:UniProtKB.
DR Gene3D; 3.10.260.20; -; 1.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR Pfam; PF02437; Ski_Sno; 1.
DR SUPFAM; SSF46955; SSF46955; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Nucleus; Reference proteome.
FT CHAIN 1..420
FT /note="Dachshund homolog dac-1"
FT /id="PRO_0000453151"
FT REGION 23..77
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..171
FT /note="DACHbox-N"
FT /evidence="ECO:0000250|UniProtKB:Q9UI36"
FT REGION 242..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 242..257
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 258..276
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 285..321
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..103
FT /note="Missing (in isoform b)"
FT /evidence="ECO:0000305"
FT /id="VSP_061105"
SQ SEQUENCE 420 AA; 46807 MW; 6BC74A32CCE7BC0D CRC64;
MQELSQLGGY FQKLAAGGFV INPSSSSSSS NNSSSNTSSS NFLSPYEYQE SSTSPRDTTD
SSGESSLSSS GSSSSLNGSC NVAAKLIKFR GHNVAAFDIN GKEMICLPQV YEVFLKNMVG
GLHTVYTKLK RLYIHPMVCN VEQVRALRSL GAIQPGVNRC KLLKTSDFEK LYDDCTSTCT
RPGRPSKRSF DDWNNGAVII KKDKTDSEPV NGPVFNQLMQ PQMTPQQILM QHFVALSQKT
KNSFERADDD DQNQRDADDI TPLNLSKSGG NSENDSDSLE NMRKEDSSPN TSVSDRGGSN
SNSLSMSMEA GSSSSSGKND EASMMNKVMS LIELASQQFK HEREELWKER SEIQVLRESF
HKIVQEERDL RKKLETQNKK CTAFEKRYKY VKKQLLLANA DLRRYKEKEE QSSDGNSVEL
