ID   ACT1_NAEPR              Reviewed;         374 AA.
AC   Q9NJV4;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 59.
DE   RecName: Full=Actin-1;
GN   Name=ACT1;
OS   Naegleria pringsheimi (Amoeba).
OC   Eukaryota; Discoba; Heterolobosea; Tetramitia; Eutetramitia;
OC   Vahlkampfiidae; Naegleria.
OX   NCBI_TaxID=234921;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 30961 / NB-1;
RA   Lee J.H.;
RT   "The regulation of actin gene expression during Naegleria
RT   differentiation.";
RL   Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; AF101729; AAF37002.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9NJV4; -.
DR   SMR; Q9NJV4; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   CHAIN           1..374
FT                   /note="Actin-1"
FT                   /id="PRO_0000088966"
SQ   SEQUENCE   374 AA;  41568 MW;  CDAB2D987DABD037 CRC64;
     MEEHQALVID NGSGMCKAGF AGEDAPRAVF PSLIGRPLQR SIMVGMGNKD AYVGDEAMSK
     KGILALKYPI EHGIITNWDD MEKIWHHTFY NELRVGPEEH GVLLTEAPLN PKANREKMTQ
     IMFETFRVPA MYVAIQAVLS LYASGRTTGI VLDSGDGVSH TVPIYEGYAL PHAILRLDLA
     GRDLTDYLMK ILMERGYSFN TSAEREIVRD IKEKLCYIAF DFEGEMKKAS ESTAVDTSYE
     LPDGNIITIG NERFRCPEVL FQPNFIGMEA AGVHETAFNS IGKCDIDIRK DLYSNVVLSG
     GTTMFEGIAE RMTKELTAMA PASMKIRVVA PPERKYSVWI GGSILSSLST FQSMWITAEE
     YEDAGCGIVH RKCF