ID   DACT1_DANRE             Reviewed;         821 AA.
AC   Q6QZN6; Q673G9;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Dapper homolog 1;
DE   AltName: Full=Frodo 1;
GN   Name=dact1; Synonyms=dpr1, frd1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC   TISSUE=Gastrula;
RX   PubMed=15188426; DOI=10.1002/dvdy.20060;
RA   Gillhouse M., Wagner Nyholm M., Hikasa H., Sokol S.Y., Grinblat Y.;
RT   "Two Frodo/Dapper homologs are expressed in the developing brain and
RT   mesoderm of zebrafish.";
RL   Dev. Dyn. 230:403-409(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 7-821, FUNCTION, INTERACTION WITH DVL2,
RP   SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX   PubMed=15539487; DOI=10.1242/dev.01520;
RA   Waxman J.S., Hocking A.M., Stoick C.L., Moon R.T.;
RT   "Zebrafish Dapper1 and Dapper2 play distinct roles in Wnt-mediated
RT   developmental processes.";
RL   Development 131:5909-5921(2004).
CC   -!- FUNCTION: Involved in regulation of intracellular signaling pathways
CC       during development. Specifically thought to play a role in canonical
CC       and/or non-canonical Wnt signaling pathways through interaction with
CC       DSH (Dishevelled) family proteins. Binds to dvl2 and may regulate the
CC       degradation of ctnnb1/beta-catenin, thereby modulating the
CC       transcriptional activation of target genes of the Wnt signaling
CC       pathway. Seems to activate the canonical Wnt signaling pathway.
CC       {ECO:0000269|PubMed:15539487}.
CC   -!- SUBUNIT: Interacts with dvl2. {ECO:0000269|PubMed:15539487}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:15539487}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the future mesendoderm during early
CC       gastrulation. Expressed in the prechordal plate axial mesoderm and the
CC       posterior neural plate in mid-gastrula, and in the anterior neural
CC       plate at the end of gastrulation and during somitogenesis. Strongly
CC       expressed in and the tail bud and several areas of the brain at the end
CC       of somitogenesis. {ECO:0000269|PubMed:15188426,
CC       ECO:0000269|PubMed:15539487}.
CC   -!- DOMAIN: The C-terminal PDZ-binding motif may mediate interaction with
CC       the PDZ domains of DSH (Dishevelled) family proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dapper family. {ECO:0000305}.
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DR   EMBL; AY521628; AAS09955.1; -; mRNA.
DR   EMBL; AY549443; AAT42265.1; -; mRNA.
DR   AlphaFoldDB; Q6QZN6; -.
DR   IntAct; Q6QZN6; 1.
DR   STRING; 7955.ENSDARP00000058000; -.
DR   PaxDb; Q6QZN6; -.
DR   PRIDE; Q6QZN6; -.
DR   ZFIN; ZDB-GENE-040623-3; dact1.
DR   eggNOG; ENOG502QVXB; Eukaryota.
DR   InParanoid; Q6QZN6; -.
DR   PhylomeDB; Q6QZN6; -.
DR   Reactome; R-DRE-4641258; Degradation of DVL.
DR   PRO; PR:Q6QZN6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0046329; P:negative regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:2000095; P:regulation of Wnt signaling pathway, planar cell polarity pathway; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IMP:ZFIN.
DR   InterPro; IPR024848; Dact1.
DR   InterPro; IPR024843; Dapper.
DR   PANTHER; PTHR15919; PTHR15919; 1.
DR   PANTHER; PTHR15919:SF12; PTHR15919:SF12; 1.
DR   Pfam; PF15268; Dapper; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Developmental protein; Reference proteome;
KW   Wnt signaling pathway.
FT   CHAIN           1..821
FT                   /note="Dapper homolog 1"
FT                   /id="PRO_0000191358"
FT   REGION          288..312
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          386..432
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          564..615
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          627..655
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          88..136
FT                   /evidence="ECO:0000255"
FT   MOTIF           818..821
FT                   /note="PDZ-binding"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        576..604
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        639..655
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        15
FT                   /note="A -> T (in Ref. 2; AAT42265)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        76
FT                   /note="Q -> R (in Ref. 2; AAT42265)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        171
FT                   /note="S -> I (in Ref. 2; AAT42265)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   821 AA;  90721 MW;  265F2C7C0A570F4D CRC64;
     MNEWSEMLVC RDYCALMMRD RKECDARCCR DGEGERVRAR ERLDATVAGL TELEYLRQRQ
     ELLVRSVLSC PEAAGQDKPC LTVDDSYLNT EEKLLEENIL LLRKQLNCLR RRDAGLINQL
     QELDRQISDL RLDTETSHEH VETDSRPSSG FYDLSDGASG SLSNSSNSVF SECLSSCRST
     TCLCTPLDTS LCASEGRLKP ADDPGSCAEC DCHCEDSSSG TVRRSLSASY SPSPDSSCDG
     ISKFHCDLIA KNGNDVYRYP SPLHAVAVQS PIFIQSMTSH LKDDCNFSKP GEALNDEQKP
     EQVVGSQTSS WHASQMLPNK KLDSYIYGLL QRRAQPLRTN KPRTSINTDP SKSILRQASL
     CSRAPASVQA QQWTSDLKPN WQTCLQDASA TSTEPSTASP QRQWSAESKG GTPQNGAYLS
     SSQPQNSYST TNENTNCLLK KKVSGTSKGQ LLSATPKDCP DLGSPKAVSS PKLNKHCFYN
     VEDNKTGQAM KASPLKRSPK TQTSLSCGKD SEQLAQELVS LGSSSQSQDE GGPLVSAQYI
     PAQKQNVNLQ KGGTKNIKIV KVKNSASSKS RPQVFEHVSE TVRDKHRTGS RRTRQVDEVH
     HLHKSSKKAS AKTKRIPASI PEGRILERHT SSSGARSSAQ RHHGHHRHHE AVLAKPKYKR
     NDFHRRPRGL HEIPYEEAYR RAHRRQKREM LSHMYLPSNA HYTSPYAYVG SDSEYSAECA
     SLFHSTILDT SEDERSNYTT NCFGDSESSA SEADYVAESS TSSDSEGSAG VNWRQISQAG
     SGSHGMTSAQ AKAFVKIKAS HNLKKKILRF RSGSLKLMTT V