ID   DACT1_XENTR             Reviewed;         824 AA.
AC   Q66KC9; Q28FG5;
DT   20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Dapper 1;
GN   Name=dact1; ORFNames=TEgg062l20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT   "Sequence of Xenopus tropicalis development genes.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Egg;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in regulation of intracellular signaling pathways
CC       during development. Specifically thought to play a role in canonical
CC       and/or non-canonical Wnt signaling pathways through interaction with
CC       DSH (Dishevelled) family proteins. Binds to dvl2 and regulates the
CC       degradation of ctnnb1/beta-catenin, thereby modulating the
CC       transcriptional activation of target genes of the Wnt signaling
CC       pathway. May also bind to and directly stimulate the activity of tcf7l1
CC       (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with dbf4, dvl2 and tcf7l1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The C-terminal PDZ-binding motif may mediate interaction with
CC       the PDZ domains of DSH (Dishevelled) family proteins. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the dapper family. {ECO:0000305}.
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DR   EMBL; AC160828; AAY90072.1; -; Genomic_DNA.
DR   EMBL; CR761983; CAJ81395.1; -; mRNA.
DR   EMBL; BC080457; AAH80457.1; -; mRNA.
DR   RefSeq; NP_001007950.1; NM_001007949.2.
DR   AlphaFoldDB; Q66KC9; -.
DR   SMR; Q66KC9; -.
DR   PaxDb; Q66KC9; -.
DR   GeneID; 493325; -.
DR   KEGG; xtr:493325; -.
DR   CTD; 51339; -.
DR   Xenbase; XB-GENE-478639; dact1.
DR   eggNOG; ENOG502QVXB; Eukaryota.
DR   HOGENOM; CLU_021211_1_0_1; -.
DR   InParanoid; Q66KC9; -.
DR   OMA; RAQREMM; -.
DR   OrthoDB; 674318at2759; -.
DR   PhylomeDB; Q66KC9; -.
DR   TreeFam; TF331300; -.
DR   Reactome; R-XTR-4641258; Degradation of DVL.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IBA:GO_Central.
DR   GO; GO:0046329; P:negative regulation of JNK cascade; IBA:GO_Central.
DR   GO; GO:2000095; P:regulation of Wnt signaling pathway, planar cell polarity pathway; IBA:GO_Central.
DR   GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR   InterPro; IPR024848; Dact1.
DR   InterPro; IPR024843; Dapper.
DR   PANTHER; PTHR15919; PTHR15919; 1.
DR   PANTHER; PTHR15919:SF12; PTHR15919:SF12; 1.
DR   Pfam; PF15268; Dapper; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Developmental protein; Nucleus; Reference proteome;
KW   Wnt signaling pathway.
FT   CHAIN           1..824
FT                   /note="Dapper 1"
FT                   /id="PRO_0000191357"
FT   REGION          1..34
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2..343
FT                   /note="Interaction with tcf7l1"
FT                   /evidence="ECO:0000250"
FT   REGION          61..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          131..150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          454..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          516..536
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          19..47
FT                   /evidence="ECO:0000255"
FT   MOTIF           821..824
FT                   /note="PDZ-binding"
FT                   /evidence="ECO:0000250"
FT   COMPBIAS        13..34
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   824 AA;  90817 MW;  963ADDB58FE89337 CRC64;
     MKPIPATPDH LGQHQESPRR KDKGEAESER QRTRERLEAT LAGLAELGYL RHRQELLVKS
     ALTPGAPTHG DTATRAGDTP RSLEEKFLED NILLLKKQLN CLRKRDAGLL SQLHELDKQI
     NDLKIDVEKT EEHLETDSRP SSGFYELSDG TSGSLSNSSN SVFSECLSSC HSSTCFCNPL
     ETSLNLTDGQ AKSADDFLEW LDYRDSQHET GTVRRSFSAP HSNSVDVAAD VHPKYQCDLV
     SKNGNDIYRY PSPLHAVAVQ SPMFLLSVMG NIKAEEPEEE IGPNDNDDCI VPELDHLKDE
     DSFLHQSSLC SLPLSSGKKM DGYILSIIQK KAHPVRTNKP RTSVNADPGK GILRHGSICV
     KQTGGVSQSS TVNLKNSKQT CLHSTGMISV DNSTYPSLKQ CSKESLSEQL ESKRMPSIST
     YPSCNVNELQ SQNNSRNTVK SVCQGLARGS VAMTSNVQKE NVTPNAPTNL SNASSSACNG
     SPRESTQMSA LLPQEIKVVP PVKKISPKNT LLSYHASSSF DERPPLDFKS EGSSSQSLDE
     GLLVNAHYIP AQQQGVKLHK NIKNVKIVKS STLKHRANVQ YVAENGSQTL KEKSKAVGKK
     CRFPEDLDTN KKVKKSTPRT KKTSHPNFEP AVVGRNPVAV RSGIKSHGQP KDVVLAKPKH
     KRGDYRRWKS SAEISYEEAL RRARRRAQRE MMGVYAQVPF PYASPYAYIA SDSEYSAECE
     SLFHSTVVDT SEDEQSNYTT NCFGDSESSL SEVEFVGEST TSSDTDESGG LIWSQFVHTL
     PMQATATAEL QTTAKAFVKI KASHNLKKKI LRFRSGSLKL MTTV