ID   DAD2_CANAL              Reviewed;         125 AA.
AC   Q59ZG8; A0A1D8PHB2;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=DASH complex subunit DAD2;
DE   AltName: Full=Outer kinetochore protein DAD2;
GN   Name=DAD2; OrderedLocusNames=CAALFM_C205210WA; ORFNames=CaO19.3551;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Component of the DASH complex, a microtubule-binding
CC       subcomplex of the outer kinetochore that is essential for proper
CC       chromosome segregation. The DASH complex mediates the formation and
CC       maintenance of bipolar kinetochore-microtubule attachments by forming
CC       closed rings around spindle microtubules and establishing interactions
CC       with proteins from the central kinetochore (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The DASH complex oligomerizes to form rings that encircle the
CC       microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250}. Chromosome, centromere, kinetochore
CC       {ECO:0000250}. Note=Associates with the mitotic spindle and the
CC       kinetochore. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DASH complex DAD2 family. {ECO:0000305}.
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DR   EMBL; CP017624; AOW27538.1; -; Genomic_DNA.
DR   RefSeq; XP_714910.1; XM_709817.1.
DR   AlphaFoldDB; Q59ZG8; -.
DR   BMRB; Q59ZG8; -.
DR   SMR; Q59ZG8; -.
DR   BioGRID; 1226559; 1.
DR   STRING; 237561.Q59ZG8; -.
DR   PRIDE; Q59ZG8; -.
DR   GeneID; 3643465; -.
DR   KEGG; cal:CAALFM_C205210WA; -.
DR   CGD; CAL0000174462; DAD2.
DR   VEuPathDB; FungiDB:C2_05210W_A; -.
DR   eggNOG; ENOG502SG7I; Eukaryota.
DR   HOGENOM; CLU_138063_2_0_1; -.
DR   InParanoid; Q59ZG8; -.
DR   OrthoDB; 1474727at2759; -.
DR   Proteomes; UP000000559; Chromosome 2.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0042729; C:DASH complex; IDA:CGD.
DR   GO; GO:0000776; C:kinetochore; IDA:CGD.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:1990023; C:mitotic spindle midzone; IBA:GO_Central.
DR   GO; GO:0044732; C:mitotic spindle pole body; IBA:GO_Central.
DR   GO; GO:0051233; C:spindle midzone; IDA:CGD.
DR   GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0007052; P:mitotic spindle organization; ISA:CGD.
DR   InterPro; IPR013963; DASH_Dad2.
DR   PANTHER; PTHR28036; PTHR28036; 1.
DR   Pfam; PF08654; DASH_Dad2; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis; Nucleus;
KW   Reference proteome.
FT   CHAIN           1..125
FT                   /note="DASH complex subunit DAD2"
FT                   /id="PRO_0000211592"
FT   REGION          79..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        102..125
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   125 AA;  14049 MW;  3C2608C18B7EE2B8 CRC64;
     MSKTNTAIYQ KIAEKRANLE RFREFKELTD DLVLQLESIG DKLETMNGGT ASVALILANW
     KSVVQSISLA SLALMKESND NNKEAFPEPL VRVRVGQSNE ENQDEEEADE EEGVRDSEEV
     EESTE