DAD3_CANAL
ID DAD3_CANAL Reviewed; 138 AA.
AC Q59VC6; A0A1D8PT75; Q59V81;
DT 21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 2.
DT 03-AUG-2022, entry version 80.
DE RecName: Full=DASH complex subunit DAD2;
DE AltName: Full=Outer kinetochore protein DAD2;
GN Name=DAD3; OrderedLocusNames=CAALFM_CR06160CA;
GN ORFNames=CaO19.11352, CaO19.3871;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Component of the DASH complex, a microtubule-binding
CC subcomplex of the outer kinetochore that is essential for proper
CC chromosome segregation. The DASH complex mediates the formation and
CC maintenance of bipolar kinetochore-microtubule attachments by forming
CC closed rings around spindle microtubules and establishing interactions
CC with proteins from the central kinetochore (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: The DASH complex oligomerizes to form rings that encircle the
CC microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC spindle {ECO:0000250}. Chromosome, centromere, kinetochore
CC {ECO:0000250}. Note=Associates with the mitotic spindle and the
CC kinetochore. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the DASH complex DAD3 family. {ECO:0000305}.
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DR EMBL; CP017630; AOW31326.1; -; Genomic_DNA.
DR RefSeq; XP_713496.1; XM_708403.1.
DR AlphaFoldDB; Q59VC6; -.
DR SMR; Q59VC6; -.
DR BioGRID; 1227903; 1.
DR STRING; 237561.Q59VC6; -.
DR PRIDE; Q59VC6; -.
DR GeneID; 3644864; -.
DR KEGG; cal:CAALFM_CR06160CA; -.
DR CGD; CAL0000201809; DAD3.
DR VEuPathDB; FungiDB:CR_06160C_A; -.
DR eggNOG; ENOG502S7SV; Eukaryota.
DR HOGENOM; CLU_153994_0_0_1; -.
DR InParanoid; Q59VC6; -.
DR OMA; TNYADNP; -.
DR OrthoDB; 1612670at2759; -.
DR PRO; PR:Q59VC6; -.
DR Proteomes; UP000000559; Chromosome R.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0042729; C:DASH complex; ISA:CGD.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0072686; C:mitotic spindle; IEA:InterPro.
DR GO; GO:0008608; P:attachment of spindle microtubules to kinetochore; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007052; P:mitotic spindle organization; ISA:CGD.
DR InterPro; IPR013965; DASH_Dad3.
DR PANTHER; PTHR28017; PTHR28017; 1.
DR Pfam; PF08656; DASH_Dad3; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW Coiled coil; Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..138
FT /note="DASH complex subunit DAD2"
FT /id="PRO_0000175947"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 106..138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 30..59
FT /evidence="ECO:0000255"
FT COMPBIAS 109..125
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 138 AA; 15466 MW; 386366B8999B614A CRC64;
MSFTTKDKSD DSSIITTNYA DNPNLSPIEQ KILQQYQLMN NNLIKVSNEL ELLTNTTDEF
GKGKGSSIHL VENLRQLETK LVFVYTFFKG AVYSILNAQD YIAEQETNGL EETNEEEDGN
EEDESGNVEL SGVSADEN
