ID   DADA1_RALSO             Reviewed;         429 AA.
AC   Q8Y0W7;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   05-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=D-amino acid dehydrogenase 1;
DE            EC=1.4.99.-;
GN   Name=dadA1; Synonyms=dadA; OrderedLocusNames=RSc0926; ORFNames=RS04488;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: Oxidative deamination of D-amino acids. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 +
CC         NH4(+); Xref=Rhea:RHEA:18125, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:17499, ChEBI:CHEBI:28938, ChEBI:CHEBI:35179,
CC         ChEBI:CHEBI:59871;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the DadA oxidoreductase family. {ECO:0000305}.
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DR   EMBL; AL646052; CAD14628.1; -; Genomic_DNA.
DR   RefSeq; WP_011000878.1; NC_003295.1.
DR   AlphaFoldDB; Q8Y0W7; -.
DR   SMR; Q8Y0W7; -.
DR   STRING; 267608.RSc0926; -.
DR   EnsemblBacteria; CAD14628; CAD14628; RSc0926.
DR   GeneID; 60500437; -.
DR   KEGG; rso:RSc0926; -.
DR   PATRIC; fig|267608.8.peg.949; -.
DR   eggNOG; COG0665; Bacteria.
DR   HOGENOM; CLU_007884_9_2_4; -.
DR   OMA; NDLYPRG; -.
DR   Proteomes; UP000001436; Chromosome.
DR   GO; GO:0008718; F:D-amino-acid dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019478; P:D-amino acid catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 2.
DR   HAMAP; MF_01202; DadA; 1.
DR   InterPro; IPR023080; DadA.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01266; DAO; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..429
FT                   /note="D-amino acid dehydrogenase 1"
FT                   /id="PRO_0000166143"
FT   BINDING         3..17
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   429 AA;  46534 MW;  558264B2A88AD75B CRC64;
     MRVLVLGSGV IGVTSAYYLA RAGHEVTVVD REAGPALDTS FANAGQISPG YASPWAAPGV
     PLKAIKWMFQ QHAPLSIRPD GTLFQLQWMW QMLRNCNAAS YAENKERMVR LAEYSRDCIR
     ALRAETGIAY EGRQQGTLQV FRTQQQLDGA ANDIAVLERA GVPYELLSRD DLVRSEPGLA
     STRHKLAGGL RLPNDETGDC QLFTTRLAAM AEKLGVRFRF NSRINSLIVQ NDAVRGALVD
     GEAMTADLVV VAMGSYSTPF LKNLVGVPVY PLKGFSITVP MTDAERSPVS TVLDETYKVA
     ITRFDDRIRV GGMAQIVGYD KRLDPGKRKT LEFVVSDLFP GGGDVSRATF WTGLRPMTPD
     GTPIVGPTPV RGLWINTGHG TLGWTMACGS GQLLSDLVSG RSPAIRADDL SVYRYLRGGQ
     APATKPALA