ID   DADA2_RALSO             Reviewed;         425 AA.
AC   Q8XX54;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   05-MAR-2002, sequence version 1.
DT   03-AUG-2022, entry version 102.
DE   RecName: Full=D-amino acid dehydrogenase 2;
DE            EC=1.4.99.-;
GN   Name=dadA2; OrderedLocusNames=RSc2262; ORFNames=RS01297;
OS   Ralstonia solanacearum (strain GMI1000) (Pseudomonas solanacearum).
OC   Bacteria; Proteobacteria; Betaproteobacteria; Burkholderiales;
OC   Burkholderiaceae; Ralstonia.
OX   NCBI_TaxID=267608;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GMI1000;
RX   PubMed=11823852; DOI=10.1038/415497a;
RA   Salanoubat M., Genin S., Artiguenave F., Gouzy J., Mangenot S., Arlat M.,
RA   Billault A., Brottier P., Camus J.-C., Cattolico L., Chandler M.,
RA   Choisne N., Claudel-Renard C., Cunnac S., Demange N., Gaspin C., Lavie M.,
RA   Moisan A., Robert C., Saurin W., Schiex T., Siguier P., Thebault P.,
RA   Whalen M., Wincker P., Levy M., Weissenbach J., Boucher C.A.;
RT   "Genome sequence of the plant pathogen Ralstonia solanacearum.";
RL   Nature 415:497-502(2002).
CC   -!- FUNCTION: Oxidative deamination of D-amino acids. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 +
CC         NH4(+); Xref=Rhea:RHEA:18125, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:17499, ChEBI:CHEBI:28938, ChEBI:CHEBI:35179,
CC         ChEBI:CHEBI:59871;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the DadA oxidoreductase family. {ECO:0000305}.
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DR   EMBL; AL646052; CAD15969.1; -; Genomic_DNA.
DR   RefSeq; WP_011002189.1; NC_003295.1.
DR   AlphaFoldDB; Q8XX54; -.
DR   SMR; Q8XX54; -.
DR   STRING; 267608.RSc2262; -.
DR   EnsemblBacteria; CAD15969; CAD15969; RSc2262.
DR   GeneID; 60501775; -.
DR   KEGG; rso:RSc2262; -.
DR   PATRIC; fig|267608.8.peg.2302; -.
DR   eggNOG; COG0665; Bacteria.
DR   HOGENOM; CLU_007884_9_2_4; -.
DR   OMA; WAGMRPA; -.
DR   Proteomes; UP000001436; Chromosome.
DR   GO; GO:0008718; F:D-amino-acid dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019478; P:D-amino acid catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 2.
DR   HAMAP; MF_01202; DadA; 1.
DR   InterPro; IPR023080; DadA.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01266; DAO; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..425
FT                   /note="D-amino acid dehydrogenase 2"
FT                   /id="PRO_0000166144"
FT   BINDING         3..17
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   425 AA;  44455 MW;  0723B56E5B752CA6 CRC64;
     MQITVVGAGI VGISTAYALA QEGHQVTLVE RNPGPGEGTS YANGGQLSYS YVAPLAGPGV
     LSHVPGWLLR RDSPLRLKPS LDPVLLRWGL RFIAACNRER ADRTTRELLA LSFYSRARME
     ALRAASPDLS FSFARRGKLV VYRDAAAFAS ARAQVGYQAT LGCEQHALSA DETIAREPAL
     AGARGAIVGA IYTPDEDVAD CHQLCVGLFN RLCALPNVAL RFNAGAESLW VEGRRVRGVR
     TAHEPITADA VVVAAGVASA GLLGPLRIDP GLYPLKGYSI SLPLGEGGAG SDGAPVVSVT
     DAARKIVYAR IGRTLRVAGM ADLVGWSDRL DPRRVQTLYD ETRALFPAAL RASDAGADAA
     PWAGMRPATP TGVPVVGPSP VDGLWLNVGH GALGFTLAMG SAGLLADLIA RRAPAIAAAP
     YALAR