ID   ACT1_PNECA              Reviewed;         375 AA.
AC   P43239;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Actin-1;
DE   AltName: Full=Actin I;
OS   Pneumocystis carinii.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Pneumocystidomycetes; Pneumocystidaceae; Pneumocystis.
OX   NCBI_TaxID=4754;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=8088520; DOI=10.1093/genetics/137.3.743;
RA   Fletcher L.D., McDowell J.M., Tidwell R.R., Meagher R.B., Dykstra C.C.;
RT   "Structure, expression and phylogenetic analysis of the gene encoding actin
RT   I in Pneumocystis carinii.";
RL   Genetics 137:743-750(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Miyahira Y., Hiraoka Y., Komatsu N., Takeuchi T., Aiso S.;
RT   "Genomic structure of the actin-encoding gene of Pneumocystis carinii.";
RL   Parasitol. Int. 46:289-295(1997).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; L21183; AAA63645.1; -; mRNA.
DR   EMBL; D49830; BAA23209.1; -; mRNA.
DR   PIR; S47897; S47897.
DR   AlphaFoldDB; P43239; -.
DR   SMR; P43239; -.
DR   PRIDE; P43239; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   CHAIN           1..375
FT                   /note="Actin-1"
FT                   /id="PRO_0000088996"
SQ   SEQUENCE   375 AA;  41904 MW;  D96C8BB53960BAFD CRC64;
     MEDEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGIMVGMGQK DSYVGDEAQS
     KRGILTLKYP IEHGIVSNWD DMEKIWHHTF YNELRVAPEE HPALLTEAPL NPKSNREKMT
     QIMFETFNTP AFYVAIQAVL SLYASGRTTG IVLDSGDGVT HTVPIYEGYA LPHAILRLNL
     AGRDLTDYLM KILTERGYNY TTTAEREIVR DIKERLCYVA LDFEQEIHTA SSSSSLEKSY
     ELPDGQVITI GNERFRAPEA LFQPSIVGME TCGIHETTFN SIMKCDVDIR KDLYSNIVMS
     GGTTMYPGIA DRMQKEITAL APSSMKIKIV APPERKYSVW IGGSILASLS TFQQMWISKQ
     EYDENGPSIV YRKCF