ID   ACT1_SCHMA              Reviewed;         376 AA.
AC   P53470;
DT   01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1996, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Actin-1;
OS   Schistosoma mansoni (Blood fluke).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Trematoda;
OC   Digenea; Strigeidida; Schistosomatoidea; Schistosomatidae; Schistosoma.
OX   NCBI_TaxID=6183;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=LE;
RX   PubMed=8720181; DOI=10.1016/0166-6851(95)02508-1;
RA   Oliveira G.C., Kemp W.M.;
RT   "Cloning of two actin genes from Schistosoma mansoni.";
RL   Mol. Biochem. Parasitol. 75:119-122(1995).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; M80334; AAA62377.1; -; mRNA.
DR   RefSeq; XP_018653066.1; XM_018798090.1.
DR   AlphaFoldDB; P53470; -.
DR   SMR; P53470; -.
DR   STRING; 6183.Smp_046600.1; -.
DR   PRIDE; P53470; -.
DR   EnsemblMetazoa; Smp_306600.1; Smp_306600.1; Smp_306600.
DR   GeneID; 8349762; -.
DR   KEGG; smm:Smp_046600; -.
DR   WBParaSite; Smp_306600.1; Smp_306600.1; Smp_306600.
DR   CTD; 8349762; -.
DR   eggNOG; KOG0676; Eukaryota.
DR   HOGENOM; CLU_027965_0_2_1; -.
DR   OMA; WICKSEY; -.
DR   OrthoDB; 649708at2759; -.
DR   PhylomeDB; P53470; -.
DR   Proteomes; UP000008854; Unassembled WGS sequence.
DR   ExpressionAtlas; P53470; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   2: Evidence at transcript level;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding;
KW   Reference proteome.
FT   CHAIN           1..376
FT                   /note="Actin-1"
FT                   /id="PRO_0000089005"
SQ   SEQUENCE   376 AA;  41732 MW;  ADA13D91CDBBED2B CRC64;
     MAEEDVAALV IDNGSGMCKA GFAGDDAPRA VFPSIVGRPR HQGVMVGMGQ KDSYVGDEAQ
     SKRGILTLKY PIEHGIVTNW DDMEKIWHHT FYNELRVAPE EHPVLLTEAP LNPKANREKM
     TQIMFETFNV PAMYVAIQAV LSLYASGRTT GIVLDSGDGV THTVPIYEGY ALPHAILRLD
     LAGRDLTDYM MKILTERGYS FTTTAEREIV RDIKEKLCYV ALDFEQEMGT AASSSALEKS
     YELPDGQVIT IGNERFRCPE ALFQPSFLGM EASGIHETTY NSIMKCDVDI RKDLYSNTVL
     SGGSTMYPGI ADRMQKEISA LAPSTMKIKI VAPPERKYSV WIGGSILASL STFQQMWISK
     QEYDESGPGI VHRKCF