DADA_VIBA3
ID DADA_VIBA3 Reviewed; 417 AA.
AC B7VMK8;
DT 28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-FEB-2009, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=D-amino acid dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01202};
DE EC=1.4.99.- {ECO:0000255|HAMAP-Rule:MF_01202};
GN Name=dadA {ECO:0000255|HAMAP-Rule:MF_01202}; OrderedLocusNames=VS_1133;
OS Vibrio atlanticus (strain LGP32) (Vibrio splendidus (strain Mel32)).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=575788;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LGP32;
RA Mazel D., Le Roux F.;
RT "Vibrio splendidus str. LGP32 complete genome.";
RL Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Oxidative deamination of D-amino acids. {ECO:0000255|HAMAP-
CC Rule:MF_01202}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 +
CC NH4(+); Xref=Rhea:RHEA:18125, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:17499, ChEBI:CHEBI:28938, ChEBI:CHEBI:35179,
CC ChEBI:CHEBI:59871; Evidence={ECO:0000255|HAMAP-Rule:MF_01202};
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000255|HAMAP-Rule:MF_01202};
CC -!- PATHWAY: Amino-acid degradation; D-alanine degradation; NH(3) and
CC pyruvate from D-alanine: step 1/1.
CC -!- SIMILARITY: Belongs to the DadA oxidoreductase family.
CC {ECO:0000255|HAMAP-Rule:MF_01202}.
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DR EMBL; FM954972; CAV18259.1; -; Genomic_DNA.
DR RefSeq; WP_012603643.1; NC_011753.2.
DR AlphaFoldDB; B7VMK8; -.
DR SMR; B7VMK8; -.
DR STRING; 575788.VS_1133; -.
DR PRIDE; B7VMK8; -.
DR EnsemblBacteria; CAV18259; CAV18259; VS_1133.
DR KEGG; vsp:VS_1133; -.
DR PATRIC; fig|575788.5.peg.2456; -.
DR eggNOG; COG0665; Bacteria.
DR HOGENOM; CLU_007884_9_2_6; -.
DR OMA; FWYKEDG; -.
DR OrthoDB; 573710at2; -.
DR UniPathway; UPA00043; UER00498.
DR Proteomes; UP000009100; Chromosome 1.
DR GO; GO:0008718; F:D-amino-acid dehydrogenase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0055130; P:D-alanine catabolic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.50.50.60; -; 2.
DR HAMAP; MF_01202; DadA; 1.
DR InterPro; IPR023080; DadA.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR Pfam; PF01266; DAO; 1.
DR SUPFAM; SSF51905; SSF51905; 1.
PE 3: Inferred from homology;
KW FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT CHAIN 1..417
FT /note="D-amino acid dehydrogenase"
FT /id="PRO_1000164645"
FT BINDING 3..17
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_01202"
SQ SEQUENCE 417 AA; 45865 MW; 9A8A254DDA1E1104 CRC64;
MEVIVIGSGV IGLTSAWYLA KEGHTVTVID RQDSSGKETS FANAGQISYG YSSPWAAPGI
PLKAMKWLTQ EHAPLKVKPS LSPELVAWAT KMLANCNEAK YAMNKSRMLR VANFSRECLT
HLRTSEDLAY EGRQKGTLQV FRSEKQLDAI QQDMKLLTES GIEHSLFDVD QCLSVESGLA
DVKDKLVGGL YLPHDETGDC HQFCLTLTEK AKQLGVRFVF DTEVVSLNHQ NRAIETITTT
QGEFKADAYV VASGSYSREL LKQVDLSIPV YPVKGYSLTL PIVNVDKSPT STVMDETYKV
AMTRFDDRIR IAGTAELAGF DYLIPEKRKA TIDMVIKDLF PQAGDFSKAE YWTGLRPMTP
DGTPIIGKTP IKNLFTNTGH GTLGWTMACG SGKILASVVS GSASDIKSDD LSIHRYL