ID   DADA_VIBVU              Reviewed;         417 AA.
AC   Q8DF11;
DT   27-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=D-amino acid dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01202};
DE            EC=1.4.99.- {ECO:0000255|HAMAP-Rule:MF_01202};
GN   Name=dadA {ECO:0000255|HAMAP-Rule:MF_01202}; OrderedLocusNames=VV1_0414;
OS   Vibrio vulnificus (strain CMCP6).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=216895;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CMCP6;
RA   Rhee J.H., Kim S.Y., Chung S.S., Kim J.J., Moon Y.H., Jeong H., Choy H.E.;
RT   "Complete genome sequence of Vibrio vulnificus CMCP6.";
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Oxidative deamination of D-amino acids. {ECO:0000255|HAMAP-
CC       Rule:MF_01202}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 +
CC         NH4(+); Xref=Rhea:RHEA:18125, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:17499, ChEBI:CHEBI:28938, ChEBI:CHEBI:35179,
CC         ChEBI:CHEBI:59871; Evidence={ECO:0000255|HAMAP-Rule:MF_01202};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01202};
CC   -!- SIMILARITY: Belongs to the DadA oxidoreductase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01202}.
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DR   EMBL; AE016795; AAO08937.1; -; Genomic_DNA.
DR   RefSeq; WP_011078512.1; NC_004459.3.
DR   AlphaFoldDB; Q8DF11; -.
DR   SMR; Q8DF11; -.
DR   EnsemblBacteria; AAO08937; AAO08937; VV1_0414.
DR   KEGG; vvu:VV1_0414; -.
DR   HOGENOM; CLU_007884_9_2_6; -.
DR   OMA; FWYKEDG; -.
DR   Proteomes; UP000002275; Chromosome 1.
DR   GO; GO:0008718; F:D-amino-acid dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019478; P:D-amino acid catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 2.
DR   HAMAP; MF_01202; DadA; 1.
DR   InterPro; IPR023080; DadA.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01266; DAO; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN           1..417
FT                   /note="D-amino acid dehydrogenase"
FT                   /id="PRO_0000166153"
FT   BINDING         3..17
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01202"
SQ   SEQUENCE   417 AA;  45814 MW;  5AE4665A2F350393 CRC64;
     MKAVVLGSGV VGLMSAWYLQ KAGYQVTVVD RQARSAEETS FANAGQISYG YSSPWAAPGI
     PQKALRWLME EHAPLKIKPS LDPQLLKWAT QMLANCQLSR YQVNKARMLA IANHSRECLS
     QLRQEHDIEY QGRQQGTLQV FRTQKQLIAI EKDIALLEQS GTRYQRMSVD ECIKQEPGLA
     AVSHKLTGGL YLPDDETGDC YLFCQQMTEL AQQQGVTFLF NTNVKKVNTQ GNQVVSVSTD
     AGELQADVYV VAMGSYSTAL LAKLGITIPV YPVKGYSLTV PITDESQAPV STVMDETYKV
     ALTRFDDRIR VAGTAELAGF DPAIPEKRKA TISMVVNDLF PHSGDFAKAE FWTGFRPMTP
     DGTPLIGKTP LKNLYTNTGH GTLGWTMACG SGHLLSQIIT GEQSENPAGL DLFRYAS