ID   DADA_VIBVY              Reviewed;         417 AA.
AC   Q7MND7;
DT   16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-JAN-2004, sequence version 2.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=D-amino acid dehydrogenase {ECO:0000255|HAMAP-Rule:MF_01202};
DE            EC=1.4.99.- {ECO:0000255|HAMAP-Rule:MF_01202};
GN   Name=dadA {ECO:0000255|HAMAP-Rule:MF_01202}; OrderedLocusNames=VV0781;
OS   Vibrio vulnificus (strain YJ016).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC   Vibrio.
OX   NCBI_TaxID=196600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=YJ016;
RX   PubMed=14656965; DOI=10.1101/gr.1295503;
RA   Chen C.-Y., Wu K.-M., Chang Y.-C., Chang C.-H., Tsai H.-C., Liao T.-L.,
RA   Liu Y.-M., Chen H.-J., Shen A.B.-T., Li J.-C., Su T.-L., Shao C.-P.,
RA   Lee C.-T., Hor L.-I., Tsai S.-F.;
RT   "Comparative genome analysis of Vibrio vulnificus, a marine pathogen.";
RL   Genome Res. 13:2577-2587(2003).
CC   -!- FUNCTION: Oxidative deamination of D-amino acids. {ECO:0000255|HAMAP-
CC       Rule:MF_01202}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=A + a D-alpha-amino acid + H2O = a 2-oxocarboxylate + AH2 +
CC         NH4(+); Xref=Rhea:RHEA:18125, ChEBI:CHEBI:13193, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:17499, ChEBI:CHEBI:28938, ChEBI:CHEBI:35179,
CC         ChEBI:CHEBI:59871; Evidence={ECO:0000255|HAMAP-Rule:MF_01202};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01202};
CC   -!- SIMILARITY: Belongs to the DadA oxidoreductase family.
CC       {ECO:0000255|HAMAP-Rule:MF_01202}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC93544.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; BA000037; BAC93544.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_011149612.1; NC_005139.1.
DR   AlphaFoldDB; Q7MND7; -.
DR   SMR; Q7MND7; -.
DR   STRING; 672.VV93_v1c07260; -.
DR   EnsemblBacteria; BAC93544; BAC93544; BAC93544.
DR   KEGG; vvy:VV0781; -.
DR   PATRIC; fig|196600.6.peg.795; -.
DR   eggNOG; COG0665; Bacteria.
DR   HOGENOM; CLU_007884_9_2_6; -.
DR   OMA; FWYKEDG; -.
DR   OrthoDB; 573710at2; -.
DR   Proteomes; UP000002675; Chromosome I.
DR   GO; GO:0008718; F:D-amino-acid dehydrogenase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0019478; P:D-amino acid catabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.50.50.60; -; 2.
DR   HAMAP; MF_01202; DadA; 1.
DR   InterPro; IPR023080; DadA.
DR   InterPro; IPR006076; FAD-dep_OxRdtase.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   Pfam; PF01266; DAO; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
PE   3: Inferred from homology;
KW   FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..417
FT                   /note="D-amino acid dehydrogenase"
FT                   /id="PRO_0000166154"
FT   BINDING         3..17
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01202"
SQ   SEQUENCE   417 AA;  45845 MW;  564FBC875150DFF1 CRC64;
     MKAVVLGSGV VGLMSAWYLQ KSGYQVTVVD RQARSAEETS FANAGQISYG YSSPWAAPGI
     PQKALRWLME EHAPLKIKPS LDPQLLKWAT QMLANCQLSR YQVNKARMLA IANHSRECLS
     QLRQEHDIEY QGRQQGTLQI FRTQKQLIAI EKDIALLEQS GTRYQRMSVD ECIKQEPGLA
     AVSHKLTGGL YLPDDETGDC YLFCQQMTEL AQQQGVTFLF NTNVKKVNAQ GNQVVSVSTD
     AGELQADVYV VAMGSYSTAL LAQLGITIPV YPVKGYSLTV PITDESQAPV STVMDETYKV
     ALTRFDDRIR VAGTAELAGF DPAIPEKRKA TISMVVNDLF PHSGDFAKAE FWTGFRPMTP
     DGTPLIGKTP LKNLYTNTGH GTLGWTMACG SGHLLSQIIT GEQSENQAGL DLFRYAS