ID   ACT1_TETTH              Reviewed;         376 AA.
AC   P10992;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Actin, macronuclear;
OS   Tetrahymena thermophila.
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=5911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=16593729; DOI=10.1073/pnas.83.14.5160;
RA   Cupples C.G., Pearlman R.E.;
RT   "Isolation and characterization of the actin gene from Tetrahymena
RT   thermophila.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:5160-5164(1986).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; M13939; AAA30109.1; -; Genomic_DNA.
DR   PIR; A29407; A29407.
DR   PDB; 1DEJ; X-ray; 2.40 A; A=-.
DR   PDBsum; 1DEJ; -.
DR   AlphaFoldDB; P10992; -.
DR   SMR; P10992; -.
DR   PRIDE; P10992; -.
DR   EvolutionaryTrace; P10992; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   1: Evidence at protein level;
KW   3D-structure; ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT   CHAIN           2..376
FT                   /note="Actin, macronuclear"
FT                   /id="PRO_0000089035"
SQ   SEQUENCE   376 AA;  42040 MW;  305664BE08134A13 CRC64;
     MAESESPAIV IDNGSGMCKA GIAGDDAPRA AFPSIVGRPK MPGIMVGMDQ KECYVGEEAQ
     AKRGVLNLKY PIEHGIVTDY DDMEKIWHHC FYNELRVTPE EHPCLLTEAP QNPKLNREKM
     TKTMFETFNV PSFYVAIQAV LSLYASGRTT GIVVDSGDGV THTVPIYEGY ALPHAILRID
     LAGRELTEYC MKLLYEIGLN FSSTAEREII RDIKEKLCYV AIDYEAELKA YKESSQNDKS
     YELPDGNTIT VQDQRFRCPE LLFKPAFIGK EFPGIHELTF NSIMKCDVDV RKDPYNNIVL
     SGGTTMFPGI AERLSKEVSA LAPSSMKIKV VAPPERRYSV WIGGSILSSL STFQTMWITK
     AEYDESGPSI VHRKCF