ID   ACT1_TRYBB              Reviewed;         376 AA.
AC   P12432;
DT   01-OCT-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1989, sequence version 1.
DT   25-MAY-2022, entry version 80.
DE   RecName: Full=Actin A;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=3386635; DOI=10.1128/mcb.8.5.2166-2176.1988;
RA   Ben-Amar M.F., Pays A., Tebabi P., Dero B., Seebeck T., Steinert M.,
RA   Pays E.;
RT   "Structure and transcription of the actin gene of Trypanosoma brucei.";
RL   Mol. Cell. Biol. 8:2166-2176(1988).
CC   -!- FUNCTION: Actins are highly conserved proteins that are involved in
CC       various types of cell motility and are ubiquitously expressed in all
CC       eukaryotic cells.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton.
CC   -!- SIMILARITY: Belongs to the actin family. {ECO:0000305}.
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DR   EMBL; M20310; AAA30151.1; -; Genomic_DNA.
DR   AlphaFoldDB; P12432; -.
DR   SMR; P12432; -.
DR   GO; GO:0097014; C:ciliary plasm; IDA:GeneDB.
DR   GO; GO:0005737; C:cytoplasm; IDA:GeneDB.
DR   GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR043129; ATPase_NBD.
DR   PANTHER; PTHR11937; PTHR11937; 1.
DR   Pfam; PF00022; Actin; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SUPFAM; SSF53067; SSF53067; 2.
DR   PROSITE; PS00406; ACTINS_1; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Cytoplasm; Cytoskeleton; Nucleotide-binding.
FT   CHAIN           1..376
FT                   /note="Actin A"
FT                   /id="PRO_0000089046"
SQ   SEQUENCE   376 AA;  41944 MW;  2528E04FF9505F31 CRC64;
     MSDEEQTAIV CDNGSGMVKS GFSGDDAPRH VFPSIVGRPK NEQAMMGSAN KKLFVGDEAQ
     AKRGVLALKY PIEHGIVTNW DDMEKVWHHT FYNELRVNPE SHNVLLTEAP MNPKQNREKM
     TQIMFETFGV PAMYVGIQAV LSLYSSGRTT GIVLDAGDGV THTVPIYEGY SLPHAIRRVD
     MAGRDLTEYL MKILMHTGMT FTTSAEKEIV RNIKEQLCYV ALDFDEEMTN SAKSVSEEPF
     ELPDGNVMQV GNQRFRCPEA LFKPALIGLD EAPGFHEMTF QSINKCDIDV RRDLYGNIVL
     SGGTTMFKNL PERLAKEISN LPPSSIKPKV VAPPERKYSV WIGGSILSSL TTFQSMWITK
     SEYDESGPSI VHSKCF