ID   DAFT_TRYCR              Reviewed;          95 AA.
AC   Q26327;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1997, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Trypomastigote decay-accelerating factor;
DE            Short=T-DAF;
DE   Flags: Fragment;
OS   Trypanosoma cruzi.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX   NCBI_TaxID=5693;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Miranda 88;
RX   PubMed=7689538; DOI=10.1128/iai.61.9.3656-3663.1993;
RA   Tambourgi D.V., Kipnis T.L., da Silva W.D., Joiner K.A., Sher A., Heath S.,
RA   Hall B.F., Ogden G.B.;
RT   "A partial cDNA clone of trypomastigote decay-accelerating factor (T-DAF),
RT   a developmentally regulated complement inhibitor of Trypanosoma cruzi, has
RT   genetic and functional similarities to the human complement inhibitor
RT   DAF.";
RL   Infect. Immun. 61:3656-3663(1993).
CC   -!- FUNCTION: Interferes with the efficient assembly of the host C3
CC       convertase. Could protect parasites from complement-mediated lysis by
CC       sera from a number of different species.
CC   -!- SIMILARITY: Belongs to the receptors of complement activation (RCA)
CC       family. {ECO:0000305}.
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DR   EMBL; S65519; AAB27990.1; -; mRNA.
DR   AlphaFoldDB; Q26327; -.
DR   SMR; Q26327; -.
DR   VEuPathDB; TriTrypDB:BCY84_02486; -.
DR   VEuPathDB; TriTrypDB:C3747_21g214; -.
DR   VEuPathDB; TriTrypDB:C4B63_68g70; -.
DR   VEuPathDB; TriTrypDB:Tc_MARK_9479; -.
DR   VEuPathDB; TriTrypDB:TcBrA4_0045020; -.
DR   VEuPathDB; TriTrypDB:TcCL_Unassigned06099; -.
DR   VEuPathDB; TriTrypDB:TcCLB.509601.10; -.
DR   VEuPathDB; TriTrypDB:TcCLB.509767.10; -.
DR   VEuPathDB; TriTrypDB:TCDM_11487; -.
DR   VEuPathDB; TriTrypDB:TcG_06871; -.
DR   VEuPathDB; TriTrypDB:TCSYLVIO_000225; -.
DR   VEuPathDB; TriTrypDB:TcYC6_0176850; -.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR008377; Sialidase_trypan.
DR   PRINTS; PR01803; TCSIALIDASE.
DR   SUPFAM; SSF49899; SSF49899; 1.
PE   2: Evidence at transcript level;
FT   CHAIN           <1..>95
FT                   /note="Trypomastigote decay-accelerating factor"
FT                   /id="PRO_0000048522"
FT   NON_TER         1
FT   NON_TER         95
SQ   SEQUENCE   95 AA;  10702 MW;  22061D66A04D6997 CRC64;
     EFGILEDGET IFVYVNGQML GSSKTMPTGK ERLLDISHFY FGGDNGEEKG NRHVKVRNVL
     LYNRVLSASE LQCRLPEEVV QKPQSASPTY LKARI