ID   DAH53_RANDH             Reviewed;          20 AA.
AC   P84269;
DT   23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Dahlein-5.3;
OS   Ranoidea dahlii (Dahl's aquatic frog) (Litoria dahlii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Hyloidea; Hylidae; Pelodryadinae; Ranoidea.
OX   NCBI_TaxID=299727;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   MASS SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:11555873};
RX   PubMed=11555873; DOI=10.1002/rcm.429;
RA   Wegener K.L., Brinkworth C.S., Bowie J.H., Wallace J.C., Tyler M.J.;
RT   "Bioactive dahlein peptides from the skin secretions of the Australian
RT   aquatic frog Litoria dahlii: sequence determination by electrospray mass
RT   spectrometry.";
RL   Rapid Commun. Mass Spectrom. 15:1726-1734(2001).
CC   -!- FUNCTION: Has no antimicrobial activity. Strongly inhibits the
CC       formation of NO by neuronal nitric oxide synthase at micromolar
CC       concentrations. {ECO:0000269|PubMed:11555873}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:11555873}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin dorsal glands.
CC       {ECO:0000269|PubMed:11555873}.
CC   -!- MASS SPECTROMETRY: Mass=2025; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:11555873};
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DR   AlphaFoldDB; P84269; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0030235; F:nitric-oxide synthase regulator activity; IDA:UniProtKB.
DR   GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR   GO; GO:0051001; P:negative regulation of nitric-oxide synthase activity; IDA:UniProtKB.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Direct protein sequencing; Secreted.
FT   PEPTIDE         1..20
FT                   /note="Dahlein-5.3"
FT                   /id="PRO_0000043779"
SQ   SEQUENCE   20 AA;  2027 MW;  DC47974471BD1201 CRC64;
     GLLASLGKVL GGYLAEKLKP