DAL4_YEAST
ID DAL4_YEAST Reviewed; 635 AA.
AC Q04895; D6VVV9;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Allantoin permease;
DE AltName: Full=Allantoin transport protein;
GN Name=DAL4; OrderedLocusNames=YIR028W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1293888; DOI=10.1002/yea.320081202;
RA Yoo H.S., Cunningham T.S., Cooper T.G.;
RT "The allantoin and uracil permease gene sequences of Saccharomyces
RT cerevisiae are nearly identical.";
RL Yeast 8:997-1006(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169870;
RA Churcher C.M., Bowman S., Badcock K., Bankier A.T., Brown D.,
RA Chillingworth T., Connor R., Devlin K., Gentles S., Hamlin N., Harris D.E.,
RA Horsnell T., Hunt S., Jagels K., Jones M., Lye G., Moule S., Odell C.,
RA Pearson D., Rajandream M.A., Rice P., Rowley N., Skelton J., Smith V.,
RA Walsh S.V., Whitehead S., Barrell B.G.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome IX.";
RL Nature 387:84-87(1997).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Transport of allantoin.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the purine-cytosine permease (2.A.39) family.
CC {ECO:0000305}.
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DR EMBL; Z15121; CAA78826.1; -; Genomic_DNA.
DR EMBL; Z38061; CAA86188.1; -; Genomic_DNA.
DR EMBL; BK006942; DAA08575.1; -; Genomic_DNA.
DR PIR; S30018; S30018.
DR RefSeq; NP_012294.3; NM_001179550.3.
DR AlphaFoldDB; Q04895; -.
DR SMR; Q04895; -.
DR BioGRID; 35019; 30.
DR DIP; DIP-7194N; -.
DR IntAct; Q04895; 1.
DR STRING; 4932.YIR028W; -.
DR TCDB; 2.A.39.3.1; the nucleobase:cation symporter-1 (ncs1) family.
DR PaxDb; Q04895; -.
DR EnsemblFungi; YIR028W_mRNA; YIR028W; YIR028W.
DR GeneID; 854846; -.
DR KEGG; sce:YIR028W; -.
DR SGD; S000001467; DAL4.
DR VEuPathDB; FungiDB:YIR028W; -.
DR eggNOG; KOG2466; Eukaryota.
DR GeneTree; ENSGT00940000176299; -.
DR HOGENOM; CLU_021555_2_2_1; -.
DR InParanoid; Q04895; -.
DR OMA; GIQTMFG; -.
DR BioCyc; YEAST:G3O-31446-MON; -.
DR PRO; PR:Q04895; -.
DR Proteomes; UP000002311; Chromosome IX.
DR RNAct; Q04895; protein.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0005274; F:allantoin:proton symporter activity; IMP:SGD.
DR GO; GO:0015205; F:nucleobase transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0000256; P:allantoin catabolic process; IMP:SGD.
DR GO; GO:0015720; P:allantoin transport; IMP:SGD.
DR GO; GO:0015851; P:nucleobase transport; IBA:GO_Central.
DR GO; GO:0006144; P:purine nucleobase metabolic process; IEA:UniProtKB-KW.
DR InterPro; IPR012681; NCS1.
DR InterPro; IPR001248; Pur-cyt_permease.
DR InterPro; IPR045225; Uracil/uridine/allantoin_perm.
DR PANTHER; PTHR30618; PTHR30618; 1.
DR Pfam; PF02133; Transp_cyt_pur; 1.
DR TIGRFAMs; TIGR00800; ncs1; 1.
PE 1: Evidence at protein level;
KW Membrane; Purine metabolism; Reference proteome; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..635
FT /note="Allantoin permease"
FT /id="PRO_0000197919"
FT TOPO_DOM 1..144
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 166..174
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 175..195
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 196..198
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 199..219
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..243
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 244..264
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 265..269
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..311
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 312..332
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 333..351
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 352..372
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 373..401
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 402..422
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 423..443
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 444..464
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 465..466
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 467..487
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 488..522
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 523..543
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 544..560
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 561..581
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 582..635
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 635 AA; 71756 MW; 4728BBC786DC6698 CRC64;
MANDALSAIF SNPSRKGVQP STSIVSYTNN EDDIIDVENG KFNKNKNINT NVYVDNSSIE
ESEVVPLPET KSIWSKIYYD FIVLDKTTLN VSLKESFLYN RDLKPVEEER RCWSWFNYLY
FWLADCFNIN TWQIAGTGLQ LGLNWWQCWL TVWIGYTFAG IFVVLNSRFG SAYHLSFPIT
VRASFGIFFS MWPIINRVVM AIVWYAVQAW LGATPVALML KSIFGKNLED RIPNHFGSPN
STTFEFMCFF IFWVVSIPFV LVAPHKIRHL FTVKAALIPF AAFGFLIWAL KKSHGKIELG
TLNDYSPHGS EFSWIFVRSL MACVANFAAL IINAPDFGRF AKNPQASLWP QLVAIPLFFA
ITCLIGIIVT AAGYHLYGVN YWSPLDVLGQ FLETTYTRGT RAGVFLISFV FALAQLGTNI
SANSLACGAD MTALFPRYIN IRRGSLFCVA MALCICPWNL MASSSKFTSA LGAYAIFLSS
IAGVICADYF VVRRGYVKLT HLFLAQKGSF YMFGNKFGAN WRAFVAYICG IAPNLPGFIG
DVGAPKITVS EGAMRLYYLG YPVGFFISAV IYLILCYFFP VPGTPVTNFL TEKGWFQRWA
YVEDFEQDWK NELRRDDLCD DTVSIYDGTE EKIVY
