DAL5_YEAST
ID DAL5_YEAST Reviewed; 543 AA.
AC P15365; D6VWX1;
DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-APR-1990, sequence version 1.
DT 03-AUG-2022, entry version 169.
DE RecName: Full=Allantoate permease;
GN Name=DAL5; Synonyms=UREP1; OrderedLocusNames=YJR152W; ORFNames=J2230;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3275614; DOI=10.1128/jb.170.1.266-271.1988;
RA Rai R., Genbauffe F.S., Cooper T.G.;
RT "Structure and transcription of the allantoate permease gene (DAL5) from
RT Saccharomyces cerevisiae.";
RL J. Bacteriol. 170:266-271(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8641269; DOI=10.1002/j.1460-2075.1996.tb00557.x;
RA Galibert F., Alexandraki D., Baur A., Boles E., Chalwatzis N., Chuat J.-C.,
RA Coster F., Cziepluch C., de Haan M., Domdey H., Durand P., Entian K.-D.,
RA Gatius M., Goffeau A., Grivell L.A., Hennemann A., Herbert C.J.,
RA Heumann K., Hilger F., Hollenberg C.P., Huang M.-E., Jacq C.,
RA Jauniaux J.-C., Katsoulou C., Kirchrath L., Kleine K., Kordes E.,
RA Koetter P., Liebl S., Louis E.J., Manus V., Mewes H.-W., Miosga T.,
RA Obermaier B., Perea J., Pohl T.M., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rasmussen S.W., Rose M., Rossau R.,
RA Schaaff-Gerstenschlaeger I., Smits P.H.M., Scarcez T., Soriano N.,
RA To Van D., Tzermia M., Van Broekhoven A., Vandenbol M., Wedler H.,
RA von Wettstein D., Wambutt R., Zagulski M., Zollner A., Karpfinger-Hartl L.;
RT "Complete nucleotide sequence of Saccharomyces cerevisiae chromosome X.";
RL EMBO J. 15:2031-2049(1996).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [4]
RP TOPOLOGY [LARGE SCALE ANALYSIS].
RC STRAIN=ATCC 208353 / W303-1A;
RX PubMed=16847258; DOI=10.1073/pnas.0604075103;
RA Kim H., Melen K., Oesterberg M., von Heijne G.;
RT "A global topology map of the Saccharomyces cerevisiae membrane proteome.";
RL Proc. Natl. Acad. Sci. U.S.A. 103:11142-11147(2006).
CC -!- FUNCTION: Component of the allantoate transport system.
CC -!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. Allantoate
CC permease family. {ECO:0000305}.
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DR EMBL; M24098; AAA34555.1; -; Genomic_DNA.
DR EMBL; Z49652; CAA89685.1; -; Genomic_DNA.
DR EMBL; BK006943; DAA08937.1; -; Genomic_DNA.
DR PIR; A28671; A28671.
DR RefSeq; NP_012686.3; NM_001181810.3.
DR AlphaFoldDB; P15365; -.
DR SMR; P15365; -.
DR BioGRID; 33907; 68.
DR DIP; DIP-7873N; -.
DR IntAct; P15365; 5.
DR MINT; P15365; -.
DR STRING; 4932.YJR152W; -.
DR TCDB; 2.A.1.14.4; the major facilitator superfamily (mfs).
DR PaxDb; P15365; -.
DR PRIDE; P15365; -.
DR EnsemblFungi; YJR152W_mRNA; YJR152W; YJR152W.
DR GeneID; 853617; -.
DR KEGG; sce:YJR152W; -.
DR SGD; S000003913; DAL5.
DR VEuPathDB; FungiDB:YJR152W; -.
DR eggNOG; KOG2533; Eukaryota.
DR HOGENOM; CLU_001265_0_5_1; -.
DR InParanoid; P15365; -.
DR OMA; CMFPLMC; -.
DR BioCyc; YEAST:G3O-31765-MON; -.
DR PRO; PR:P15365; -.
DR Proteomes; UP000002311; Chromosome X.
DR RNAct; P15365; protein.
DR GO; GO:0071944; C:cell periphery; HDA:SGD.
DR GO; GO:0000324; C:fungal-type vacuole; HDA:SGD.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031224; C:intrinsic component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IMP:SGD.
DR GO; GO:0015124; F:allantoate transmembrane transporter activity; IMP:SGD.
DR GO; GO:0071916; F:dipeptide transmembrane transporter activity; IMP:SGD.
DR GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0015719; P:allantoate transport; IMP:SGD.
DR GO; GO:0042938; P:dipeptide transport; IMP:SGD.
DR GO; GO:0042939; P:tripeptide transport; IMP:SGD.
DR Gene3D; 1.20.1250.20; -; 2.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR036259; MFS_trans_sf.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
PE 1: Evidence at protein level;
KW Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..543
FT /note="Allantoate permease"
FT /id="PRO_0000121366"
FT TOPO_DOM 1..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..97
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..123
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 124..145
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 146..154
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 155..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..178
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 179..200
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 201..213
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 214..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 238..248
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 249..269
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 270..317
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 318..342
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 343..352
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 353..377
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 378..389
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 390..411
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 412..417
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 418..435
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 436..453
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 454..472
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 473..482
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 483..504
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 505..543
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
SQ SEQUENCE 543 AA; 60850 MW; 9B70CAF3FA1D0BB8 CRC64;
MSADASTNSN ASLDEKNLNI TSEAEIKNED VTAEPVLSTV LSPNGKIVYI SDKVDEAMKL
AEEAKEIEVT PEEDRKLRWK IDYCMFPLMC ILYAVQFMDK ISTSSAAVMG LRTDLKMHGD
QYSWVTSAFY FGYLFMNLGP VQFIFQRTSH MSKMLAVFIV IWGMLLALHA APTVKYPSFI
VLRVLLGCAE SVVTPCFTII TAQYWKTEEQ FTRVSIWFGM NGLGSILINA IAYGVYIHQD
SYAIKGWRTL FVITGVITIF IGILIFLWIP DDPSKARFLS KREKLMVVQR IRSNQQGFGN
HEIKKYQIIE ALKDVRTWLY FLFTVSSNIP NGGISSFMSI LLNSDFGYSS KETLLMGLPT
GAVELVGCPL FGILAVYAAN KKIPFWKYKL SWAIFAAVLA LIASCMLGFA TNSKKARLAG
AYLWYISPVS FICVLSNISA NSSGYSKKWT VSSINLVAYA AANLAGPQTF IAKQAPKYHG
AKVAMVVCYA VMIVLLSILL IVNLRENKRR DKIAAERGFP EETENLEFSD LTDFENPNFR
YTL
