DAL80_YEAST
ID DAL80_YEAST Reviewed; 269 AA.
AC P26343; D6VX97;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Nitrogen regulatory protein DAL80;
DE AltName: Full=Regulatory protein UGA43;
GN Name=DAL80; Synonyms=UGA43; OrderedLocusNames=YKR034W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1944286; DOI=10.1128/mcb.11.12.6205-6215.1991;
RA Cunningham T.S., Cooper T.G.;
RT "Expression of the DAL80 gene, whose product is homologous to the GATA
RT factors and is a negative regulator of multiple nitrogen catabolic genes in
RT Saccharomyces cerevisiae, is sensitive to nitrogen catabolite repression.";
RL Mol. Cell. Biol. 11:6205-6215(1991).
RN [2]
RP ERRATUM OF PUBMED:1944286.
RX PubMed=1569960; DOI=10.1128/mcb.12.5.2454-.1992;
RA Cunningham T.S., Cooper T.G.;
RL Mol. Cell. Biol. 12:2454-2454(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=1525858; DOI=10.1007/bf00351687;
RA Coornaert D., Vissers S., Andre B., Grenson M.;
RT "The UGA43 negative regulatory gene of Saccharomyces cerevisiae contains
RT both a GATA-1 type zinc finger and a putative leucine zipper.";
RL Curr. Genet. 21:301-307(1992).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=8196765; DOI=10.1038/369371a0;
RA Dujon B., Alexandraki D., Andre B., Ansorge W., Baladron V.,
RA Ballesta J.P.G., Banrevi A., Bolle P.-A., Bolotin-Fukuhara M., Bossier P.,
RA Bou G., Boyer J., Buitrago M.J., Cheret G., Colleaux L.,
RA Daignan-Fornier B., del Rey F., Dion C., Domdey H., Duesterhoeft A.,
RA Duesterhus S., Entian K.-D., Erfle H., Esteban P.F., Feldmann H.,
RA Fernandes L., Fobo G.M., Fritz C., Fukuhara H., Gabel C., Gaillon L.,
RA Garcia-Cantalejo J.M., Garcia-Ramirez J.J., Gent M.E., Ghazvini M.,
RA Goffeau A., Gonzalez A., Grothues D., Guerreiro P., Hegemann J.H.,
RA Hewitt N., Hilger F., Hollenberg C.P., Horaitis O., Indge K.J.,
RA Jacquier A., James C.M., Jauniaux J.-C., Jimenez A., Keuchel H.,
RA Kirchrath L., Kleine K., Koetter P., Legrain P., Liebl S., Louis E.J.,
RA Maia e Silva A., Marck C., Monnier A.-L., Moestl D., Mueller S.,
RA Obermaier B., Oliver S.G., Pallier C., Pascolo S., Pfeiffer F.,
RA Philippsen P., Planta R.J., Pohl F.M., Pohl T.M., Poehlmann R.,
RA Portetelle D., Purnelle B., Puzos V., Ramezani Rad M., Rasmussen S.W.,
RA Remacha M.A., Revuelta J.L., Richard G.-F., Rieger M.,
RA Rodrigues-Pousada C., Rose M., Rupp T., Santos M.A., Schwager C.,
RA Sensen C., Skala J., Soares H., Sor F., Stegemann J., Tettelin H.,
RA Thierry A., Tzermia M., Urrestarazu L.A., van Dyck L.,
RA van Vliet-Reedijk J.C., Valens M., Vandenbol M., Vilela C., Vissers S.,
RA von Wettstein D., Voss H., Wiemann S., Xu G., Zimmermann J., Haasemann M.,
RA Becker I., Mewes H.-W.;
RT "Complete DNA sequence of yeast chromosome XI.";
RL Nature 369:371-378(1994).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
CC -!- FUNCTION: Negative regulator of multiple nitrogen catabolic genes
CC including the allantoin pathway genes.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- INDUCTION: Sensitive to nitrogen catabolite repression.
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DR EMBL; M77821; AAA34556.1; -; Genomic_DNA.
DR EMBL; X60199; CAA42757.1; -; Genomic_DNA.
DR EMBL; Z28259; CAA82107.1; -; Genomic_DNA.
DR EMBL; Z28258; CAA82106.1; -; Genomic_DNA.
DR EMBL; BK006944; DAA09187.1; -; Genomic_DNA.
DR PIR; S22781; S22781.
DR RefSeq; NP_012959.1; NM_001179824.1.
DR AlphaFoldDB; P26343; -.
DR SMR; P26343; -.
DR BioGRID; 34165; 98.
DR DIP; DIP-2094N; -.
DR IntAct; P26343; 19.
DR STRING; 4932.YKR034W; -.
DR iPTMnet; P26343; -.
DR PaxDb; P26343; -.
DR PRIDE; P26343; -.
DR EnsemblFungi; YKR034W_mRNA; YKR034W; YKR034W.
DR GeneID; 853904; -.
DR KEGG; sce:YKR034W; -.
DR SGD; S000001742; DAL80.
DR VEuPathDB; FungiDB:YKR034W; -.
DR eggNOG; KOG1601; Eukaryota.
DR GeneTree; ENSGT00940000176497; -.
DR HOGENOM; CLU_054982_0_0_1; -.
DR InParanoid; P26343; -.
DR OMA; CIAMEIK; -.
DR BioCyc; YEAST:G3O-32007-MON; -.
DR PRO; PR:P26343; -.
DR Proteomes; UP000002311; Chromosome XI.
DR RNAct; P26343; protein.
DR GO; GO:0005634; C:nucleus; IDA:SGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:SGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:SGD.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:SGD.
DR GO; GO:0042128; P:nitrate assimilation; IEA:UniProtKB-KW.
DR GO; GO:0090295; P:nitrogen catabolite repression of transcription; IMP:SGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00202; ZnF_GATA; 1.
DR Gene3D; 3.30.50.10; -; 1.
DR InterPro; IPR039355; Transcription_factor_GATA.
DR InterPro; IPR000679; Znf_GATA.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR10071; PTHR10071; 2.
DR Pfam; PF00320; GATA; 1.
DR PRINTS; PR00619; GATAZNFINGER.
DR SMART; SM00401; ZnF_GATA; 1.
DR PROSITE; PS00344; GATA_ZN_FINGER_1; 1.
DR PROSITE; PS50114; GATA_ZN_FINGER_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nitrate assimilation; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1..269
FT /note="Nitrogen regulatory protein DAL80"
FT /id="PRO_0000083470"
FT ZN_FING 31..55
FT /note="GATA-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00094"
FT CONFLICT 6
FT /note="S -> L (in Ref. 3; CAA42757)"
FT /evidence="ECO:0000305"
FT CONFLICT 207
FT /note="V -> I (in Ref. 3; CAA42757)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 269 AA; 30166 MW; F37BEB10038599EC CRC64;
MVLSDSLKLP SPTLSAAAGV DDCDGEDHPT CQNCFTVKTP LWRRDEHGTV LCNACGLFLK
LHGEPRPISL KTDTIKSRNR KKLNNNNVNT NANTHSNDPN KIFKRKKRLL TTGGGSLPTN
NPKVSILEKF MVSGSIKPLL KPKETVPNTK ECSTQRGKFS LDPCEPSGKN YLYQINGSDI
YTSNIELTRL PNLSTLLEPS PFSDSAVPEI ELTWKLHNEE EVIKLKTKIS ELELVTDLYK
KHIFQLNEKC KQLEVELHSR ASVQSHPQH
