DALD3_MOUSE
ID DALD3_MOUSE Reviewed; 538 AA.
AC Q6PJN8; Q8C1T1; Q9D1L6;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=DALR anticodon-binding domain-containing protein 3;
GN Name=Dalrd3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Bone marrow, Heart, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in tRNA methylation. Facilitates the recognition and
CC targeting of tRNA(Arg)(CCU) and tRNA(Arg)(UCU) substrates for N(3)-
CC methylcytidine modification by METTL2. {ECO:0000250|UniProtKB:Q5D0E6}.
CC -!- SUBUNIT: Part of a complex containing tRNA(Arg) and METTL2. Interacts
CC with tRNA(Arg)(CCU) and tRNA(Arg)(UCU). Interacts with METTL2.
CC {ECO:0000250|UniProtKB:Q5D0E6}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PJN8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PJN8-2; Sequence=VSP_030747;
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DR EMBL; AK002439; BAC24990.1; -; mRNA.
DR EMBL; AK003374; BAB22747.1; -; mRNA.
DR EMBL; AK149963; BAE29197.1; -; mRNA.
DR EMBL; AK169405; BAE41151.1; -; mRNA.
DR EMBL; AK171818; BAE42679.1; -; mRNA.
DR EMBL; BC013483; AAH13483.2; -; mRNA.
DR CCDS; CCDS40769.1; -. [Q6PJN8-1]
DR RefSeq; NP_080654.3; NM_026378.3. [Q6PJN8-1]
DR RefSeq; XP_017169029.1; XM_017313540.1. [Q6PJN8-1]
DR AlphaFoldDB; Q6PJN8; -.
DR SMR; Q6PJN8; -.
DR STRING; 10090.ENSMUSP00000019183; -.
DR iPTMnet; Q6PJN8; -.
DR PhosphoSitePlus; Q6PJN8; -.
DR EPD; Q6PJN8; -.
DR MaxQB; Q6PJN8; -.
DR PaxDb; Q6PJN8; -.
DR PeptideAtlas; Q6PJN8; -.
DR PRIDE; Q6PJN8; -.
DR ProteomicsDB; 277943; -. [Q6PJN8-1]
DR ProteomicsDB; 277944; -. [Q6PJN8-2]
DR Antibodypedia; 30345; 110 antibodies from 22 providers.
DR DNASU; 67789; -.
DR Ensembl; ENSMUST00000019183; ENSMUSP00000019183; ENSMUSG00000019039. [Q6PJN8-1]
DR GeneID; 67789; -.
DR KEGG; mmu:67789; -.
DR UCSC; uc009rqi.1; mouse. [Q6PJN8-1]
DR CTD; 55152; -.
DR MGI; MGI:1915039; Dalrd3.
DR VEuPathDB; HostDB:ENSMUSG00000019039; -.
DR eggNOG; KOG1195; Eukaryota.
DR GeneTree; ENSGT00390000014621; -.
DR HOGENOM; CLU_041286_1_1_1; -.
DR InParanoid; Q6PJN8; -.
DR OMA; RDPHMPT; -.
DR PhylomeDB; Q6PJN8; -.
DR TreeFam; TF325601; -.
DR BioGRID-ORCS; 67789; 1 hit in 72 CRISPR screens.
DR ChiTaRS; Dalrd3; mouse.
DR PRO; PR:Q6PJN8; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q6PJN8; protein.
DR Bgee; ENSMUSG00000019039; Expressed in retinal neural layer and 257 other tissues.
DR ExpressionAtlas; Q6PJN8; baseline and differential.
DR Genevisible; Q6PJN8; MM.
DR GO; GO:0004814; F:arginine-tRNA ligase activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; ISS:UniProtKB.
DR GO; GO:0006420; P:arginyl-tRNA aminoacylation; IEA:InterPro.
DR GO; GO:0106217; P:tRNA C3-cytosine methylation; ISO:MGI.
DR InterPro; IPR008909; DALR_anticod-bd.
DR InterPro; IPR037380; DALRD3.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR PANTHER; PTHR16043; PTHR16043; 1.
DR Pfam; PF05746; DALR_1; 1.
DR SMART; SM00836; DALR_1; 1.
DR SUPFAM; SSF47323; SSF47323; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Reference proteome.
FT CHAIN 1..538
FT /note="DALR anticodon-binding domain-containing protein 3"
FT /id="PRO_0000315849"
FT VAR_SEQ 1..371
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_030747"
FT CONFLICT 517
FT /note="R -> G (in Ref. 1; BAC24990)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 538 AA; 58733 MW; 866BF4B5C115B3A4 CRC64;
MATGRLGVGE TLEALNAAVG PGSPVWFKET HARHLRVRDF LAPRSALQAR FRDGQVPECV
FRAVSCLQGP GVAPVLRCAP TPAGLSLQLQ RPAVFEHVLG ALASYATPAK PASPGPRVVL
HCPALRCNSG TLRLSQLRAV LVADHLVRVL RAHGVRVCSV PPVRDPHMST FLQKLRVEWP
TASKSTSTET LRTCVLANLN GSKEATLPPG VLGRLCLKEL VEQRGTAGYD PSIDHCLVTE
DVLSVLSELQ EAVRHWPEGG HPGPAGRPDA GVDDCVVIHV VSCEEAFQQQ KLDLLWQKLD
DRAPHKQKHL VCGPVKMAGV PGTQLTAPQY YRLRHAQVCE ASALKHGGDL AQDPAWTETF
DILSVATIKF EMLSTAPQSQ LLLAHSTIST KGTKSGTFVM YNCARLATLF EGYKHGTEQG
LYPTFPLVSS LDFSLLHDEG EWLLLFNSVL PFLDLLSQTV SLAGTPGLHI PVRTEMVCKF
LVQLSMDFSS YYNRVHILGE PRPHLFGQMF ARLQLLRAVR EVFHTGLAML GLPPLSHI
