ID   ACT24_STRCO             Reviewed;         255 AA.
AC   P46106;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 127.
DE   RecName: Full=Probable actinorhodin operon activatory protein;
GN   Name=actII-4; OrderedLocusNames=SCO5085; ORFNames=SCBAC28G1.11;
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1878971; DOI=10.1016/0092-8674(91)90120-n;
RA   Fernandez-Moreno M.A., Caballero J.L., Hopwood D.A., Malpartida F.;
RT   "The act cluster contains regulatory and antibiotic export genes, direct
RT   targets for translational control by the bldA tRNA gene of Streptomyces.";
RL   Cell 66:769-780(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
CC   -!- FUNCTION: Transcriptional activator of actinorhodin biosynthetic genes.
CC   -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; M64683; AAA26692.1; -; Genomic_DNA.
DR   EMBL; AL939122; CAC44198.1; -; Genomic_DNA.
DR   PIR; D40046; D40046.
DR   RefSeq; NP_629235.1; NC_003888.3.
DR   RefSeq; WP_003973893.1; NZ_VNID01000008.1.
DR   AlphaFoldDB; P46106; -.
DR   SMR; P46106; -.
DR   STRING; 100226.SCO5085; -.
DR   GeneID; 1100526; -.
DR   KEGG; sco:SCO5085; -.
DR   PATRIC; fig|100226.15.peg.5165; -.
DR   eggNOG; COG3629; Bacteria.
DR   HOGENOM; CLU_004665_0_1_11; -.
DR   InParanoid; P46106; -.
DR   OMA; WHENLHA; -.
DR   PhylomeDB; P46106; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0003677; F:DNA binding; IBA:GO_Central.
DR   GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd15831; BTAD; 1.
DR   Gene3D; 1.10.10.10; -; 1.
DR   Gene3D; 1.25.40.10; -; 1.
DR   InterPro; IPR005158; BTAD.
DR   InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR   InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF03704; BTAD; 1.
DR   Pfam; PF00486; Trans_reg_C; 1.
DR   SMART; SM01043; BTAD; 1.
DR   SMART; SM00862; Trans_reg_C; 1.
DR   SUPFAM; SSF46894; SSF46894; 1.
DR   SUPFAM; SSF48452; SSF48452; 1.
DR   PROSITE; PS51755; OMPR_PHOB; 1.
PE   3: Inferred from homology;
KW   Activator; Antibiotic biosynthesis; DNA-binding; Reference proteome;
KW   Transcription; Transcription regulation; Two-component regulatory system.
FT   CHAIN           1..255
FT                   /note="Probable actinorhodin operon activatory protein"
FT                   /id="PRO_0000110003"
FT   DNA_BIND        1..98
FT                   /note="OmpR/PhoB-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01091"
SQ   SEQUENCE   255 AA;  28762 MW;  59E1E749C37F3AAD CRC64;
     MRFNLLGRVH VITDAGCVIP LKSSKATQLL VLLLLRRHEV VGSGVLIEEL WADHPPRSAM
     TTLQTYVYHT RRLLGEHRVT SDDRELVLTQ PPGYFALIDE DELDVAVAER LIRTGGRLLE
     ENRLEEALAS LDAGLDLWRG PALSTVPCGR VLESNIAHLE ELRLFGMQLR IDANWRLGRI
     GPMIPELRSL VISHPLNETL HAKLMGALCQ MGRRAEALES YRNLRRILSD ELGVDPTPEI
     QRMHMEILNG EKVLV