ID   DALD_YERPE              Reviewed;         463 AA.
AC   P58709; Q0WEJ6;
DT   31-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   31-JAN-2002, sequence version 1.
DT   25-MAY-2022, entry version 131.
DE   RecName: Full=D-arabinitol 4-dehydrogenase;
DE            EC=1.1.1.11;
GN   Name=dalD; OrderedLocusNames=YPO2325, y2008, YP_2112;
OS   Yersinia pestis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Yersiniaceae; Yersinia.
OX   NCBI_TaxID=632;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CO-92 / Biovar Orientalis;
RX   PubMed=11586360; DOI=10.1038/35097083;
RA   Parkhill J., Wren B.W., Thomson N.R., Titball R.W., Holden M.T.G.,
RA   Prentice M.B., Sebaihia M., James K.D., Churcher C.M., Mungall K.L.,
RA   Baker S., Basham D., Bentley S.D., Brooks K., Cerdeno-Tarraga A.-M.,
RA   Chillingworth T., Cronin A., Davies R.M., Davis P., Dougan G., Feltwell T.,
RA   Hamlin N., Holroyd S., Jagels K., Karlyshev A.V., Leather S., Moule S.,
RA   Oyston P.C.F., Quail M.A., Rutherford K.M., Simmonds M., Skelton J.,
RA   Stevens K., Whitehead S., Barrell B.G.;
RT   "Genome sequence of Yersinia pestis, the causative agent of plague.";
RL   Nature 413:523-527(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=KIM10+ / Biovar Mediaevalis;
RX   PubMed=12142430; DOI=10.1128/jb.184.16.4601-4611.2002;
RA   Deng W., Burland V., Plunkett G. III, Boutin A., Mayhew G.F., Liss P.,
RA   Perna N.T., Rose D.J., Mau B., Zhou S., Schwartz D.C., Fetherston J.D.,
RA   Lindler L.E., Brubaker R.R., Plano G.V., Straley S.C., McDonough K.A.,
RA   Nilles M.L., Matson J.S., Blattner F.R., Perry R.D.;
RT   "Genome sequence of Yersinia pestis KIM.";
RL   J. Bacteriol. 184:4601-4611(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=91001 / Biovar Mediaevalis;
RX   PubMed=15368893; DOI=10.1093/dnares/11.3.179;
RA   Song Y., Tong Z., Wang J., Wang L., Guo Z., Han Y., Zhang J., Pei D.,
RA   Zhou D., Qin H., Pang X., Han Y., Zhai J., Li M., Cui B., Qi Z., Jin L.,
RA   Dai R., Chen F., Li S., Ye C., Du Z., Lin W., Wang J., Yu J., Yang H.,
RA   Wang J., Huang P., Yang R.;
RT   "Complete genome sequence of Yersinia pestis strain 91001, an isolate
RT   avirulent to humans.";
RL   DNA Res. 11:179-197(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-arabinitol + NAD(+) = D-xylulose + H(+) + NADH;
CC         Xref=Rhea:RHEA:17921, ChEBI:CHEBI:15378, ChEBI:CHEBI:17140,
CC         ChEBI:CHEBI:18333, ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=1.1.1.11;
CC   -!- PATHWAY: Carbohydrate metabolism; D-arabinitol metabolism.
CC   -!- SIMILARITY: Belongs to the mannitol dehydrogenase family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAM85574.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AL590842; CAL20953.1; -; Genomic_DNA.
DR   EMBL; AE009952; AAM85574.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AE017042; AAS62321.1; -; Genomic_DNA.
DR   PIR; AF0283; AF0283.
DR   RefSeq; WP_002211002.1; NZ_WUCM01000054.1.
DR   RefSeq; YP_002347292.1; NC_003143.1.
DR   AlphaFoldDB; P58709; -.
DR   SMR; P58709; -.
DR   STRING; 214092.YPO2325; -.
DR   PaxDb; P58709; -.
DR   DNASU; 1146955; -.
DR   EnsemblBacteria; AAM85574; AAM85574; y2008.
DR   EnsemblBacteria; AAS62321; AAS62321; YP_2112.
DR   GeneID; 57976349; -.
DR   KEGG; ype:YPO2325; -.
DR   KEGG; ypk:y2008; -.
DR   KEGG; ypm:YP_2112; -.
DR   PATRIC; fig|1028802.3.peg.1067; -.
DR   eggNOG; COG0246; Bacteria.
DR   HOGENOM; CLU_027324_0_2_6; -.
DR   OMA; GETFIQW; -.
DR   UniPathway; UPA00380; -.
DR   Proteomes; UP000000815; Chromosome.
DR   Proteomes; UP000001019; Chromosome.
DR   Proteomes; UP000002490; Chromosome.
DR   GO; GO:0047813; F:D-arabinitol 4-dehydrogenase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008866; F:fructuronate reductase activity; IBA:GO_Central.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IBA:GO_Central.
DR   GO; GO:0051161; P:arabitol metabolic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0042840; P:D-glucuronate catabolic process; IBA:GO_Central.
DR   Gene3D; 1.10.1040.10; -; 1.
DR   InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR   InterPro; IPR013328; 6PGD_dom2.
DR   InterPro; IPR000669; Mannitol_DH.
DR   InterPro; IPR013118; Mannitol_DH_C.
DR   InterPro; IPR013131; Mannitol_DH_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01232; Mannitol_dh; 1.
DR   Pfam; PF08125; Mannitol_dh_C; 1.
DR   PRINTS; PR00084; MTLDHDRGNASE.
DR   SUPFAM; SSF48179; SSF48179; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   NAD; Oxidoreductase; Reference proteome.
FT   CHAIN           1..463
FT                   /note="D-arabinitol 4-dehydrogenase"
FT                   /id="PRO_0000170737"
SQ   SEQUENCE   463 AA;  51985 MW;  D82E8988685B5EDD CRC64;
     MNTDLKSPPA VWLHIGAGSF HRAHQAWYLH RLLASGDDRW TIALANIRDD AIPLLDTLRA
     QHGEYVLETV TPSGERQYEK ITSLRNIIPW DKALDHLVAQ GSKPETRVIS FTVTEGGYYL
     DNQFNLQQDN SDIQADLRGD CRTIYGAISR ILQQRQQDKS GPVTLLNCDN LRHNGERFRH
     GLLEFLALRG QQSLLNWVTS QTRSPNTMVD RITPRPSADI AQRVLEKTGI VDNAPVMGES
     FIQWVIEDDF IAGRPALENV GAEMVTSVLP YEEAKIRILN ASHSCIAWAG SLIGQCYIHE
     STQTDAIRQM AYDYVTQDVI PSLTPSPLDL AHYRDVVLER FSNPYIRDTN QRVAADGFSK
     IPGFITPTLI ECYQRGGVPT ATAMLPALFF VFMESWHQGT LPYEYQDGIL DPAAVHAMFQ
     SSDPAGLFAR DSALFGPLAN DDQFEQLLRQ SINRVSAWVS TNR