DALMA_DROME
ID DALMA_DROME Reviewed; 857 AA.
AC Q9VH89; Q9U449;
DT 08-FEB-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Protein dalmatian;
DE AltName: Full=Sororin ortholog;
GN Name=dmt; ORFNames=CG8374;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=11102367; DOI=10.1093/genetics/156.4.1691;
RA Prokopenko S.N., He Y., Lu Y., Bellen H.J.;
RT "Mutations affecting the development of the peripheral nervous system in
RT Drosophila: a molecular screen for novel proteins.";
RL Genetics 156:1691-1715(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-173; SER-175; SER-184;
RP SER-222 AND SER-405, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
RN [6]
RP FUNCTION.
RX PubMed=21111234; DOI=10.1016/j.cell.2010.10.031;
RA Nishiyama T., Ladurner R., Schmitz J., Kreidl E., Schleiffer A.,
RA Bhaskara V., Bando M., Shirahige K., Hyman A.A., Mechtler K., Peters J.M.;
RT "Sororin mediates sister chromatid cohesion by antagonizing wapl.";
RL Cell 143:737-749(2010).
CC -!- FUNCTION: Regulator of sister chromatid cohesion in mitosis. Probably
CC involved in development of the central nervous system.
CC {ECO:0000269|PubMed:11102367, ECO:0000269|PubMed:21111234}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}. Chromosome {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed in numerous tissues including the CNS
CC throughout most of embryogenesis. {ECO:0000269|PubMed:11102367}.
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DR EMBL; AF203478; AAF18985.1; -; mRNA.
DR EMBL; AE014297; AAF54430.1; -; Genomic_DNA.
DR EMBL; AY058684; AAL13913.1; -; mRNA.
DR RefSeq; NP_524295.1; NM_079571.2.
DR AlphaFoldDB; Q9VH89; -.
DR BioGRID; 66339; 14.
DR IntAct; Q9VH89; 8.
DR STRING; 7227.FBpp0081564; -.
DR iPTMnet; Q9VH89; -.
DR PaxDb; Q9VH89; -.
DR DNASU; 41180; -.
DR EnsemblMetazoa; FBtr0082086; FBpp0081564; FBgn0278604.
DR GeneID; 41180; -.
DR KEGG; dme:Dmel_CG8374; -.
DR UCSC; CG8374-RA; d. melanogaster.
DR CTD; 41180; -.
DR FlyBase; FBgn0278604; dmt.
DR VEuPathDB; VectorBase:FBgn0278604; -.
DR eggNOG; ENOG502TJUP; Eukaryota.
DR HOGENOM; CLU_021996_0_0_1; -.
DR InParanoid; Q9VH89; -.
DR OMA; NSTMYVP; -.
DR OrthoDB; 1134264at2759; -.
DR PhylomeDB; Q9VH89; -.
DR SignaLink; Q9VH89; -.
DR BioGRID-ORCS; 41180; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 41180; -.
DR PRO; PR:Q9VH89; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0278604; Expressed in ovary and 17 other tissues.
DR Genevisible; Q9VH89; DM.
DR GO; GO:0000785; C:chromatin; IDA:FlyBase.
DR GO; GO:0000792; C:heterochromatin; IDA:FlyBase.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0071478; P:cellular response to radiation; IMP:FlyBase.
DR GO; GO:0007064; P:mitotic sister chromatid cohesion; IMP:UniProtKB.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:FlyBase.
DR GO; GO:0007399; P:nervous system development; IMP:FlyBase.
DR GO; GO:0007422; P:peripheral nervous system development; TAS:FlyBase.
DR GO; GO:0007428; P:primary branching, open tracheal system; IMP:FlyBase.
DR GO; GO:0007431; P:salivary gland development; IMP:FlyBase.
DR GO; GO:0060438; P:trachea development; IMP:FlyBase.
DR InterPro; IPR018605; Sororin.
DR Pfam; PF09666; Sororin; 2.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Chromosome; Mitosis; Nucleus; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..857
FT /note="Protein dalmatian"
FT /id="PRO_0000403976"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 146..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 251..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 470..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 737..830
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 146..175
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..267
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 488..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 756..777
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 173
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 175
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 184
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 222
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 405
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT CONFLICT 746
FT /note="A -> T (in Ref. 1; AAF18985)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 857 AA; 96513 MW; FD12048017B2A146 CRC64;
MVRTRPVPCV PSPDVNTATR RNPGRPKKQS IGADLSTTIS KPGRPKKLSI GADLTTIRKP
GRPKKLGADL TTIIRKPGRP TKLSNKQSLT ALNEPECRIR KCVVKIRRIK VKNGVVSEIS
RNDAPDVDAS TFEPARNSTM YIPSKVQKST QPQNIKENVA GPETSPCQQR IRSKSPSGPA
AEISPKKPPR FFHRDQPLTR TRSSVTRNVF DFLSQSQIED DSDREDPAAD IIQRLVKDGK
ACVMVRSRKI GKPRAKRTAK KVRPVGNRRK VSTKDNEPEP VKVVPKSIEP RLQKPSRSLS
TIFEPEEDYS NDSEHGYVQP IEVPVQVHVE PSTSKQAHEG AYSNLARSVM LNQTQAQNPL
PSTDRRRELI NMARQLVSTP LNRRAPPVTD VSATTTALSP IAHQSPNAVR TAGGKSPWRV
SDDSPLPNTF MFGFNNSQMP SYSSDHVQRR HVYVPDSPVE HAENIPHEES ICPPLHEQNH
DSNANDSNEE NRPPPTISKS MSINDQESEE NAENFVHLPN PRRTLQKRTP FKDINILEVV
TLPSWKKNVT ATVSKEITPT RVAPRPMATS SPAQRSQTRS NLFGFDDDFA CEDIPRKSTT
PSKGIAPTSM SLNREVTPAL ANRNQTEVNT FGCNEILPCE NIPKEKETNT EERTSSSQNL
FGFDEFITES QDSPANFTGL SQNVNLHDKL HRLAELRPRD GELPQVSYTS IRSDCLGESH
SKQTDIRYML CSTMIAPPRP AKRKPAAPTA RESMGLFRVD QDEPEQSFAD KQPRRTYVKE
RPQRKRKKRV QILYIESESE DEDEQDSHDK SLDSPEKKRH HVKRPRRDIE HEAKLEQFVT
SFNKQCEEVE KFPVIIE
