ID   DAM1_YARLI              Reviewed;         223 AA.
AC   Q6C2T8;
DT   21-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=DASH complex subunit DAM1;
DE   AltName: Full=Outer kinetochore protein DAM1;
GN   Name=DAM1; OrderedLocusNames=YALI0F05236g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the DASH complex, a microtubule-binding
CC       subcomplex of the outer kinetochore that is essential for proper
CC       chromosome segregation. The DASH complex mediates the formation and
CC       maintenance of bipolar kinetochore-microtubule attachments by forming
CC       closed rings around spindle microtubules and establishing interactions
CC       with proteins from the central kinetochore (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: The DASH complex oligomerizes to form rings that encircle the
CC       microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton,
CC       spindle {ECO:0000250}. Chromosome, centromere, kinetochore
CC       {ECO:0000250}. Note=Associates with the mitotic spindle and the
CC       kinetochore. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the DASH complex DAM1 family. {ECO:0000305}.
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DR   EMBL; CR382132; CAG77831.1; -; Genomic_DNA.
DR   RefSeq; XP_505024.1; XM_505024.1.
DR   AlphaFoldDB; Q6C2T8; -.
DR   SMR; Q6C2T8; -.
DR   STRING; 4952.CAG77831; -.
DR   EnsemblFungi; CAG77831; CAG77831; YALI0_F05236g.
DR   GeneID; 2908164; -.
DR   KEGG; yli:YALI0F05236g; -.
DR   VEuPathDB; FungiDB:YALI0_F05236g; -.
DR   HOGENOM; CLU_083960_0_0_1; -.
DR   InParanoid; Q6C2T8; -.
DR   OMA; IREAHGY; -.
DR   Proteomes; UP000001300; Chromosome F.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0042729; C:DASH complex; IBA:GO_Central.
DR   GO; GO:1990537; C:mitotic spindle polar microtubule; IBA:GO_Central.
DR   GO; GO:0044732; C:mitotic spindle pole body; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:1990758; P:mitotic sister chromatid biorientation; IBA:GO_Central.
DR   InterPro; IPR013962; DASH_Dam1.
DR   PANTHER; PTHR28113; PTHR28113; 1.
DR   Pfam; PF08653; DASH_Dam1; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Centromere; Chromosome; Chromosome partition;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Kinetochore; Microtubule; Mitosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..223
FT                   /note="DASH complex subunit DAM1"
FT                   /id="PRO_0000127662"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          114..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          94..125
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        117..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   223 AA;  25253 MW;  539E2BB26DB87305 CRC64;
     MQRPTTPLRR SNSRQSDHEE HYPIVESVLD MAIGEQMAEL ADGMSALDRN LKDLQVIHTN
     LNNFNESFST LIYGLQMNAW CAEFHNGPRS CDFARRKEVE EMEERARRAQ MQAERDRMAM
     QQIQETPTRL PSEPSDGDVT YMRNDNSFII QPPSSYQSQL PSRIPQSSRA SRIRPPNSLR
     PPRGRGLYLR GGSRGVTGGR GSYTGVGRGS GRPASEGTTR RWL